Abstract
Objective
To assess the relation of thrombotic markers, thrombomodulin and D-dimer levels to the disease severity in pediatric onset systemic lupus erythematosus (p-SLE) measured by the Systemic Lupus Erythematous Disease Activity Index (SLEDAI).
Methods
40 children with p-SLE were grouped according to SLEDAI into: low activity SLE group (laSLE) and moderate-high activity SLE group (mhaSLE). 40 healthy children were included as control group. Serum thrombomodulin, and D-dimer levels were measured for all enrolled children.
Results
The low activity and moderate-high activity SLE groups had significantly higher mean (SD) thrombomodulin [7.2 (1.83) mg/mL and 9.86 (3.29) mg/mL, respectively vs 5.85 (1.41) mg/mL; P<0.001] and D-dimer (r=0.42, P=0.006) levels than controls. Furthermore, the mhaSLE group had significantly higher thrombomodulin levels and D-dimer (r = 0.42, P= 0.006) levels than the laSLE group (P=0.008 and 0.006). Thrombomodulin and D-dimer had significant positive correlations with SLEDAI.
Conclusion
Thrombomodulin and D-dimer are valuable markers for p-SLE activity, discriminating children with severe disease activity from those with low disease activity.
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Contributors: SEM,SOM,MAA: design and planning of the study; MAA: lab work; SEM,SOM,ARA: data collection, analysis of results and preparation of drafts of the manuscript. All authors read and approved the final manuscript.
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Ethics clearance: Ethical committee of Faculty of Medicine Minia-University; No. 691:11/2020, dated Nov 1, 2020.
Competing interests: None stated.
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Maher, S.E., Abdul-Badia, A.R., Abu El-ela, M.A. et al. Association of Thrombotic Markers With Severity of Pediatric-Onset Systemic Lupus Erythematosus. Indian Pediatr 60, 736–738 (2023). https://doi.org/10.1007/s13312-023-2987-2
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DOI: https://doi.org/10.1007/s13312-023-2987-2