Abstract
Modern radiotherapy techniques have advanced and become more sophisticated. End-to-end 3D verification of the complex radiotherapy dose distribution in an anthropomorphic phantom can ensure the accuracy of the treatment delivery. The phantoms commonly used for dosimetry are homogeneous solid water phantom which lacks the capability to measure the 3D dose distribution for heterogeneous tissues necessary for advanced radiotherapy techniques. Therefore, we developed an end-to-end 3D radiotherapy dose verification system based on MAX-HD anthropomorphic phantom (Integrated Medical Technologies Inc., Troy, New York) with bespoke intracranial insert for PRESAGE® dosimeter. In this study, several advanced radiotherapy treatment techniques of various levels of complexity; 3D-CRT, IMRT and VMAT treatment, were planned for a 20 mm diameter of a spherical target in the brain region and delivered to the phantom. The dosimeters were read out using an in-house developed optical computed tomography (OCT) imaging system known as 3DmicroHD-OCT. It was found that the measured dose distribution of the PRESAGE® when compared with the measured dose distribution of EBT film and Monaco TPS has a maximum difference of less than 3% for 3D-CRT, IMRT and VMAT treatment plans. The gamma analysis results of PRESAGE® in comparison to EBT film and Monaco TPS show pass rates of more than 95% for the criteria of 3% dose difference and 3 mm distance-to-agreement. This study proves the capability of PRESAGE® and bespoke MAX-HD phantom in conjunction with the 3DmicroHD-OCT system to measure 3D dose distribution for end-to-end dosimetry verification.
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Acknowledgements
This work was supported by the Malaysia Ministry of Higher Education (MOHE) under the Fundamental Research Grant Scheme Fund, 600-IRMI/FRGS 5/3 (412/2019). We would like to thank Umar Baharom from IMT Inc. for fabricating the PRESAGE® insert design. Additionally, we extend our gratitude to the Advanced Medical & Dental Institute, Universiti Sains Malaysia, for providing the facilities to conduct the irradiation. We are also grateful to Universiti Teknologi MARA (UiTM) for granting access to the Atomic Physics & Radiation Laboratory, Faculty of Applied Sciences, and the Radiation Laboratory, Institute of Science. Special thanks go to Nurul Wahida Aziz and Mohd Shahrulrizan Ibrahim for their technical support throughout this study.
Funding
This work was supported by the Malaysia Ministry of Higher Education (MOHE) under the Fundamental Research Grant Scheme Fund, 600-IRMI/FRGS 5/3 (412/2019).
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by all authors. The first draft of the manuscript was written by Muhammad Zamir Mohyedin and Hafiz Mohd Zin and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.”
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Mohyedin, M.Z., Zin, H.M., Abubakar, A. et al. Study of PRESAGE® dosimeter for end-to-end 3D radiotherapy verification using an anthropomorphic phantom with bespoke dosimeter insert. Phys Eng Sci Med (2024). https://doi.org/10.1007/s13246-024-01418-9
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DOI: https://doi.org/10.1007/s13246-024-01418-9