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Extracellular Vesicle Application as a Novel Therapeutic Strategy for Ischemic Stroke

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Abstract

Ischemic stroke (IS) accounts for most of the cases of stroke onset, and due to short therapeutic time window for thrombolysis and numerous limited treatment measures and contraindications, lots of patients cannot receive satisfying therapeutic effects resulting in high disability and mortality worldly. In recent years, extracellular vesicles (EVs), as nanosized membrane-structured vesicles secreted from almost all cells, especially from stem/progenitor cells, have been reported to exert significant beneficial effects on IS from multiple approaches and notably ameliorate neurological outcome. Moreover, based on nano-size and lipid bilayer structure, EVs can easily penetrate the blood–brain barrier and migrate into the brain. In this review, we mainly systematically summarize the therapeutic effects of EVs on IS and explore their potential applications. Simultaneously, we also discuss administration routines, dosages, experimental observation time, and some key issues of EV application during IS treatment. It contributes to a comprehensive understanding of the progress of EV treatment for IS and providing confident evidence for further EV clinical application widely.

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Funding

This work was supported by the Science and Technology Development Fund of Macau (FDCT nos. 0093/2018/A3, 0106/2019/A2) and the National Natural Science Foundation of China (NSFC no. 82074051).

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  1. Yiyang Li and Bowen Liu contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Research Building N22, Avenida da Universidade, Taipa, Macao, 999078, SAR, China

    Yiyang Li, Bowen Liu, ** Quan, Yan Han, Ying Zheng & Yonghua Zhao

  2. Department of Neurology, Nan**g Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nan**g University of Chinese Medicine, Nan**g, 210029, Jiangsu, China

    Bowen Liu

  3. Faculty of Medicine, Macau University of Science and Technology, Macao, 999078, SAR, China

    Ying Chen

  4. GCP Center, Affiliated Hospital of Nan**g University of Chinese Medicine, Nan**g, 210029, Jiangsu, China

    Ying Chen

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Li, Y., Liu, B., Chen, Y. et al. Extracellular Vesicle Application as a Novel Therapeutic Strategy for Ischemic Stroke. Transl. Stroke Res. 13, 171–187 (2022). https://doi.org/10.1007/s12975-021-00915-3

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