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Gastric collision tumor composed of early-stage gastric carcinoma and gastrointestinal stromal tumor: a case report

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Abstract

Collision tumors composed of adenocarcinoma and gastrointestinal stromal tumor (GIST) of the stomach are extremely uncommon, and only a few cases have been reported in the English literature. In the present case, a 67-year-old woman visited a local hospital for vomiting and hematemesis. An esophagogastroduodenoscopy study indicated an elevated lesion with ulceration. Histology of the endoscopic biopsy specimen indicated gastric adenocarcinoma. The patient underwent laparoscopic distal gastrectomy with D2 lymph node dissection. The resected specimen showed that the primary tumor consisted of a GIST and that early-stage gastric carcinoma coexisted in the mucosa surrounding the central ulceration of the GIST. Although close contact of the adenocarcinoma and GIST was observed on the mucosal surface, no intermixing of tumor cells was observed in the primary tumor. This case is an extremely rare case of a collision tumor composed of early-stage gastric adenocarcinoma and GIST occurring in the stomach, which provides some insight into a better understanding of the pathogenesis of collision tumors.

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Acknowledgements

The authors would like to thank Mrs. Jennifer Holmes for her excellent medical editing of the manuscript.

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Authors and Affiliations

  1. Department of Surgery, Chiba-Ken Saiseikai Narashino Hospital, Social Welfare Organization, Saiseikai Imperial Gift Foundation, 1-Chome-1-1 Izumi-cho, Narashino city, Chiba, 275-8580, Japan

    Hiroyuki Fukuda, Yoichi Sakurai, Yoshinaga Nomoto, Yusuke Nakamura, Hirokazu Karaki & Tomohisa Okaya

  2. Department of Gastroenterology, Chiba-Ken Saiseikai Narashino Hospital, Social Welfare Organization, Saiseikai Imperial Gift Foundation, 1-Chome-1-1 Izumi-cho, Narashino city, Chiba, 275-8580, Japan

    Futoshi Hirai & Michikazu Abe

  3. Pathology Division, Chiba-Ken Saiseikai Narashino Hospital, Social Welfare Organization, Saiseikai Imperial Gift Foundation, 1-Chome-1-1 Izumi-cho, Narashino city, Chiba, 275-8580, Japan

    Isamu Sugano

Authors
  1. Hiroyuki Fukuda
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  2. Yoichi Sakurai
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  3. Yoshinaga Nomoto
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  4. Yusuke Nakamura
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  5. Hirokazu Karaki
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  6. Tomohisa Okaya
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  7. Futoshi Hirai
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  8. Michikazu Abe
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  9. Isamu Sugano
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Corresponding author

Correspondence to Yoichi Sakurai.

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Conflict of interest

Hiroyuki Fukuda, Yoichi Sakurai, Yoshinaga Nomoto, Yusuke Nakamura, Hirokazu Karaki, Tomohisa Okaya, Futoshi Hirai, Michikazu Abe, and Isamu Sugano declare that all authors have no conflict of interest.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from patient for being included in this case report.

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Fukuda, H., Sakurai, Y., Nomoto, Y. et al. Gastric collision tumor composed of early-stage gastric carcinoma and gastrointestinal stromal tumor: a case report. Clin J Gastroenterol 15, 1055–1060 (2022). https://doi.org/10.1007/s12328-022-01708-3

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  • DOI: https://doi.org/10.1007/s12328-022-01708-3

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