Abstract
A 60-year-old male presented to our hospital for further investigation of abnormal findings on an upper gastrointestinal series. Esophagogastroduodenoscopy demonstrated atrophic gastritis and a submucosal tumor (SMT) at the anterior wall of the antrum. The patient was positive for serum anti-Helicobacter pylori (H. pylori) antibody and H. pylori eradication therapy was performed. Five months later, the SMT showed a remarkable morphological change in that an ulcer had developed on its apex, and partial gastrectomy was performed. Pathological examination suggested an inflammatory fibroid polyp (IFP), and genetic analysis revealed no mutation in the platelet-derived growth factor receptor alpha gene. This case suggests that H. pylori infection plays an important role in the etiology of IFPs.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Stolte M, Sticht T, Eidt S, et al. Frequency, location, and age and sex distribution of various types of gastric polyp. Endoscopy. 1994;26:659–65.
Matsushita M, Uchida K, Nishio A, et al. Endoscopic and EUS features of gastric inflammatory fibroid polyps. Gastrointest Endosc. 2009;69:188.
Kobayashi H, Fuchigami T, Sakai T, et al. Diagnosis and treatment of inflammatory fibroid polyp of the gastrointestinal tract. Stomach Intestine. 2004;39:640–6.
Helwig EB, Ranier A. Inflammatory fibroid polyp of the stomach. Surg Gynecol Obstet. 1953;96:335–67.
Hasegawa T, Yang P, Kagawa N, et al. CD34 expression by inflammatory fibroid polyps of the stomach. Mod Pathol. 1997;10:451–6.
Santos GC, Alves VA, Wakamatsu A, et al. Inflammatory fibroid polyp: an immunohistochemical study. Arq Gastroenterol. 2004;41:104–7.
Kim MK, Higgins J, Cho EY, et al. Expression of CD34, bcl-2, and kit in inflammatory fibroid polyps of the gastrointestinal tract. Appl Immunohistochem Mol Morphol. 2000;8:147–53.
Mori M, Tamura S, Enjoji M, et al. Concomitant presence of inflammatory fibroid polyp and carcinoma or adenoma in the stomach. Arch Pathol Lab Med. 1988;112:829–32.
Yamabe K, Ogino N, Ogawa N, et al. A case of inflammatory fibroid polyp of the stomach—stastic analysis of 138 cases reported in Japan. J Jpn Surg Assoc. 1990;51:1972–5.
Nishiyama Y, Koyama S, Andoh A, et al. Gastric inflammatory fibroid polyp treated with Helicobacter pylori eradication therapy. Intern Med. 2003;42:263–7.
Kolodziejczyk P, Yao T, Tsuneyoshi M. Inflammatory fibroid polyp of the stomach. A special reference to an immunohistochemical profile of 42 cases. Am J Surg Pathol. 1993;17:1159–68.
Shalom A, Wasserman I, Segal M, et al. Inflammatory Fibroid Polyp and Helicobacter Pylori. Aetiology or Coincidence? Eur J Surg. 2000;166:54–7.
Schildaue HU, Cavlar T, Bionet E, et al. Inflammatory fibroid polyps harbor mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene. J Pathol. 2008;216:176–82.
Johanna A, Radiosa G, Christer B. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008;22:1276–312.
Hirota S, Ohashi A, Nishida T, et al. Gain-of-Function Mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors. Gastroenterology. 2003;125:660–7.
Schildhaus HU, Cavlar T, Binot E, et al. Inflammatory fibroid polyps harbour mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene. J Pathol. 2008;216:176–82.
Pablo M, Francisco M, Rodrigo K. Inflammatory fibroid polyp associated with early gastric carcinoma: a case report. Annals of Diagnostic Pathology. 2012;16:148–51.
Ljubicic N, Banic M, Kujundzic M, et al. The effect of eradicating Helicobacter pylori infection on the course of adenomatous and hyperplastic gastric polyps. Eur J Gastroenterol Hepatol. 1999;11:727–30.
Ito M, Tanaka S, Takata S, et al. Morphological changes in human gastric tumours after eradication therapy of Helicobacter pylori in a short-term follow-up. Aliment Pharmacol Ther. 2005;21:559–66.
Eguchi H, Herschenhous N, Kuzushita N, et al. Helicobacter pylori increases proteasome-mediated degradation of p27 (Ki-p1) in gasric epithelial cells. Cancer Res. 2003;63:4739–46.
Yasunaga Y, Shinomura Y, Kanayama S, et al. Increased production of interleukin 1 beta and hepatocyte growth factor may contribute to foveolar hyperplasia in enlarged fold gastritis. Gut. 1996;39:787–94.
Disclosures
Conflict of Interest:
Yasuhiro Mitsui, Kaizo Kagemoto, Tatsuzo Itagaki, Shuji Inoue, Keishi Naruse, Naoki Muguruma and Tetsuji Takayama declare that they have no conflict of interest.
Human/Animal Rights:
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).
Informed Consent:
Informed consent was obtained from all patients for being included in the study.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mitsui, Y., Kagemoto, K., Itagaki, T. et al. Gastric inflammatory fibroid polyp morphologically changed by Helicobacter pylori eradication. Clin J Gastroenterol 8, 77–81 (2015). https://doi.org/10.1007/s12328-015-0557-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12328-015-0557-z