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Preoperative mean platelet volume predicts survival in breast cancer patients with type 2 diabetes

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A Letter to the Editor to this article was published on 03 June 2019

Abstract

Purpose

Patients with type 2 diabetes mellitus (T2DM) have an increased risk of breast cancer (BC). Furthermore, growing evidence suggests that activated platelets play a crucial role in tumor and T2DM. Mean platelet volume (MPV) is a platelet index and is altered in patients with malignancies. The aim of this study was to determine whether preoperative MPV could predict survival in BC patients with T2DM.

Methods

The clinical data of 266 female BC patients with T2DM and 264 female BC patients without T2DM between January 2011 and December 2011 in our center were retrospectively analyzed. Survival analysis was performed using the log-rank test and Cox proportional hazards regression analysis.

Results

The patients with T2DM had higher MPV levels than the patients without T2DM. Furthermore, MPV was found to be significantly associated with differentiation T2DM from non-T2DM. In addition, survival analysis revealed that the disease-specific survival and overall survival of patients with MPV ≤ 8.0 fL were significantly shorter than that of those with MPV > 8.0 fL in diabetic patients. Multivariate analysis identified MPV as an independent poor prognostic factor for survival only in patients with T2DM not in patients without T2DM.

Conclusions

Our study first established a connection between MPV and BC patients with T2DM, suggesting that MPV was an independent prognostic factor and could be the biomarker for prognosis.

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References

  1. DeSantis C, Ma J, Bryan L, Jemal A. Breast cancer statistics, 2013. CA Cancer J Clin. 2014;64(1):52–62.

    Article  PubMed  Google Scholar 

  2. Zhao XB, Ren GS. Diabetes mellitus and prognosis in women with breast cancer: A systematic review and meta-analysis. Medicine (Baltimore). 2016;95(49):e5602.

    Article  Google Scholar 

  3. Peairs KS, Barone BB, Snyder CF, et al. Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis. J Clin Oncol. 2011;29(1):40–6.

    Article  PubMed  Google Scholar 

  4. Mezouar S, Frere C, Darbousset R, et al. Role of platelets in cancer and cancer-associated thrombosis: Experimental and clinical evidences. Thromb Res. 2016;139:65–766.

    Article  CAS  PubMed  Google Scholar 

  5. Suzuki K, Aiura K, Kitagou M, et al. Platelets counts closely correlate with the disease-free survival interval of pancreatic cancer patients. Hepatogastroenterology. 2004;51(57):847–53.

    PubMed  Google Scholar 

  6. Long Y, Wang T, Gao Q, Zhou C. Prognostic significance of pretreatment elevated platelet count in patients with colorectal cancer: a meta-analysis. Oncotarget. 2016;7:81849.

    PubMed  PubMed Central  Google Scholar 

  7. Pietrzyk L, Plewa Z, Denisow-Pietrzyk M, Zebrowski R, Torres K. Diagnostic power of blood parameters as screening markers in gastric cancer patients. Asian Pac J Cancer Prev. 2016;17(9):4433–7.

    PubMed  Google Scholar 

  8. Ekici H, Malatyalioglu E, Kokcu A, Kurtoglu E, Tosun M, Celik H. Do Leukocyte and platelet counts have benefit for preoperative evaluation of endometrial cancer. Asian Pac J Cancer Prev. 2015;16(13):5305–10.

    Article  PubMed  Google Scholar 

  9. Qiu J, Yu Y, Fu Y, Ye F, **e X, Lu W. Preoperative plasma fibrinogen, platelet count and prognosis in epithelial ovarian cancer. J Obstet Gynaecol Res. 2012;38(4):651–7.

    Article  CAS  PubMed  Google Scholar 

  10. Seretis C, Youssef H, Chapman M. Hypercoagulation in colorectal cancer: what can platelet indices tell us. Platelets. 2015;26(2):114–8.

    Article  CAS  PubMed  Google Scholar 

  11. Gasparyan AY, Ayvazyan L, Mikhailidis DP, et al. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17(1):47–58.

    Article  CAS  PubMed  Google Scholar 

  12. Kemal Y, Demirağ G, Ekiz K, et al. Mean platelet volume could be a useful biomarker for monitoring epithelial ovarian cancer. J Obstet Gynaecol. 2014;34(6):515–8. https://doi.org/10.3109/01443615.2014.912620.

    Article  CAS  PubMed  Google Scholar 

  13. Kumagai S, Tokuno J, Ueda Y, et al. Prognostic significance of preoperative mean platelet volume in resected non-small-cell lung cancer[J]. Mol Clin Oncol. 2015;3(1):197–201. https://doi.org/10.3892/mco.2014.436.

    Article  PubMed  Google Scholar 

  14. Shen XM, **a YY, Lian L, et al. Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer. Oncol Lett. 2016;12(4):2501–6. https://doi.org/10.3892/ol.2016.4913.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Tanriverdi O, Menekse S, Teker F, et al. The mean platelet volume may predict the development of isolated bone metastases in patients with breast cancer: a retrospective study of the Young Researchers Committee of the Turkish Oncology Group (TOG). J BUON. 2016;21(4):840–50.

    PubMed  Google Scholar 

  16. Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK, Lakshmaiah V. Mean platelet volume in Type 2 diabetes mellitus. J Lab Physicians. 2012;4:5–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Tesfamariam B. Involvement of platelets in tumor cell metastasis. Pharmacol Ther. 2016;157:112–9.

    Article  CAS  PubMed  Google Scholar 

  18. Carvalho I, Milanezi F, Martins A, Reis RM, Schmitt F. Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression. Breast Cancer Res. 2005;7(5):R788–R795795.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Kang DW, Min DS. Platelet derived growth factor increases phospholipase D1 but not phospholipase D2 expression via NFkappaB signaling pathway and enhances invasion of breast cancer cells. Cancer Lett. 2010;294(1):125–33.

    Article  CAS  PubMed  Google Scholar 

  20. Boucharaba A, Serre CM, Grès S, et al. Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer. J Clin Invest. 2004;114(12):1714–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Appiah-Kubi K, Wang Y, Qian H, et al. Platelet-derived growth factor receptor/platelet-derived growth factor (PDGFR/PDGF) system is a prognostic and treatment response biomarker with multifarious therapeutic targets in cancers. Tumour Biol. 2016;37(8):10053–66.

    Article  CAS  PubMed  Google Scholar 

  22. Lian L, Li W, Li ZY, et al. Inhibition of MCF-7 breast cancer cell-induced platelet aggregation using a combination of antiplatelet drugs. Oncol Lett. 2013;5(2):675–80.

    Article  CAS  PubMed  Google Scholar 

  23. Aksoy S, Kilickap S, Hayran M, et al. Platelet size has diagnostic predictive value for bone marrow metastasis in patients with solid tumors. Int J Lab Hematol. 2008;30(3):214–9.

    Article  CAS  PubMed  Google Scholar 

  24. Wang X, Cui MM, Xu Y, et al. Decreased mean platelet volume predicts poor prognosis in invasive bladder cancer. Oncotarget. 2017;8:68115.

    PubMed  PubMed Central  Google Scholar 

  25. Yun ZY, Zhang X, Liu YS, et al. Lower mean platelet volume predicts poor prognosis in renal cell carcinoma. Sci Rep. 2017;7(1):6700.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Gu M, Zhai Z, Huang L, et al. Pre-treatment mean platelet volume associates with worse clinicopathologic features and prognosis of patients with invasive breast cancer. Breast Cancer. 2016;23(5):752–60.

    Article  PubMed  Google Scholar 

  27. Dindar S, Cinemre H, Sengul E, Annakkaya AN. Mean platelet volume is associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus. West Indian Med J. 2013;62(6):519–23.

    Article  CAS  PubMed  Google Scholar 

  28. Han JY, Choi DH, Choi SW, et al. Stroke or coronary artery disease prediction from mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2013;24(5):401–6.

    Article  CAS  PubMed  Google Scholar 

  29. Mu L, Zhu N, Zhang J, **ng F, Li D, Wang X. Type 2 diabetes, insulin treatment and prognosis of breast cancer. Diabetes Metab Res Rev. 2017;33(1):2823.

    Article  Google Scholar 

  30. Ferroni P, Riondino S, Buonomo O, Palmirotta R, Guadagni F, Roselli M. Type 2 Diabetes and Breast Cancer: The Interplay between Impaired Glucose Metabolism and Oxidant Stress. Oxid Med Cell Longev. 2015;2015:183928.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Cornillie F, Hanauer SB, Diamond RH, et al. Postinduction serum infliximab trough level and decrease of C-reactive protein level are associated with durable sustained response to infliximab: a retrospective analysis of the ACCENT I trial. Gut. 2014;63:1721–7.

    Article  CAS  PubMed  Google Scholar 

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Funding

This work was supported by Natural Science Foundation of Heilongjiang Province of China (ZD2017017) and Science Foundation of Heilongjiang Academy of Medical Science (Grant no. 201811).

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Author notes

  1. Na Li and ** ST, Nangang District, Harbin, 150081, China

    Na Li, ** ST, Nangang District, Harbin, 150081, China

    Yuan-xi Huang

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  1. Na Li
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  2. **n-hai Lv
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  3. **n Wang
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  4. Rui-tao Wang
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  5. Yuan-xi Huang
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Correspondence to Rui-tao Wang or Yuan-xi Huang.

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Li, N., Lv, Xh., Wang, X. et al. Preoperative mean platelet volume predicts survival in breast cancer patients with type 2 diabetes. Breast Cancer 26, 712–718 (2019). https://doi.org/10.1007/s12282-019-00976-1

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  • DOI: https://doi.org/10.1007/s12282-019-00976-1

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