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Boosting image-guiding radiation therapy through W18O49 nanospheres and the second near-infrared light irradiation

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Abstract

More than 60% of cancer patients receive radiation therapy (RT) during their anticancer treatment. However, there is a huge challenge to improve the therapeutic efficacy of RT in less radioresponsive tumors and decrease damages dealt to the surrounding healthy tissues. Herein, we have reported the development of an efficacious RT treatment of relatively radioresistant breast cancer using W18O49 nanospheres and the second near-infrared (NIR) light irradiation. Featuring the X-ray attenuation ability and photothermal effect, together with ability to generate intracellular singlet oxygen and ·OH, W18O49 nanospheres can significantly increase radiation-induced DNA damage and decrease the mitochondrial membrane potential of cancer cells during RT, causing in nearby three-times improvement in inhibiting the proliferation of 4T1 cells. The in vivo evaluations verify that a rather effective therapeutic outcome is achieved by treatment of 4T1 tumor xenograft with NIR-enhanced RT using W18O49 nanospheres. Moreover, the X-ray attenuation ability and the strong near-infrared absorption of W18O49 nanospheres have enabled highly resolved in vivo computer tomography (CT)/photoacoustic (PA) imaging. This work presents an “all-in-one” synergistic platform to improve the therapeutic efficacy of RT in less radioresponsive tumors, therefore opening a new door for multimodal cancer therapy.

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Acknowledgements

This work was supported by the National Science Fund for Distinguished Young Scholars (No. 51825202, S. Q. L.), the National Natural Science Foundation of China (Nos. 21775032 (S. Q. L.) and U20A20339 (N. N. Z.)), and Heilongjiang Touyan Innovation Team Program (S. Q. L.).

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Authors and Affiliations

  1. School of Life Science and Technology, MOE Key Laboratory of Micro-systems and Micro-structures Manufacturing, Harbin Institute of Technology, Harbin, 150080, China

    Nannan Zheng, Shouhao Zhang, Zhilin Qi, Jia Jiao & Shaoqin Liu

  2. NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, Harbin, 150001, China

    Lu Wang, Qiang Peng, Lingrui Jian, Yang Bai, Jiachen Shen & Wanhai Xu

  3. The First Affiliated Hospital, Department of Endodontics, Harbin Medical University, Harbin, 150080, China

    Ranxu Wang

  4. Department of Gynecological Radiotherapy, Harbin Medical University Cancer Hospital, Harbin, 150081, China

    Yue Feng

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  1. Nannan Zheng
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  2. Shouhao Zhang
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  3. Lu Wang
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Zheng, N., Zhang, S., Wang, L. et al. Boosting image-guiding radiation therapy through W18O49 nanospheres and the second near-infrared light irradiation. Nano Res. 15, 2315–2323 (2022). https://doi.org/10.1007/s12274-021-3814-0

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