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Neuroprotective strategies to prevent and treat Parkinson’s disease based on its pathophysiological mechanism

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Abstract

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease after Alzheimer’s disease. PD exhibits clinical symptoms that include tremors, rigidity, and bradykinesia. Many drugs are available to treat PD, such as, l-dopa, COMT inhibitor, MAO-B inhibitor, and dopamine agonists, but these drugs simply compensate for dopamine loss in PD, and therefore, cannot completely suppress its symptoms or progression. Although the causes of PD are not clearly understood, common pathophysiological pathways, such as, oxidative stress, mitochondrial dysfunction, and neuroinflammation are considered to be etiological factors, and thus, many treatments and interventions have been developed to target these pathophysiological factors. This review describes the neuroprotective strategies devised based on current understanding of the pathophysiological mechanisms of PD.

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Acknowledgement

This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (MSIP) (Grant No. 2009-0083538). This work was also supported by the Basic Science Research Program through NRF funded by the Ministry of Education (Grant No. NRF-2016R1D1A3B03933222).

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  1. Department of Pharmacy, College of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan, 609-735, Republic of Korea

    Yujeong Lee & Jaewon Lee

  2. Department of Pharmacy, College of Pharmacy, Sunchon National University, Sunchon, 57922, Republic of Korea

    Min-Sun Kim

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  1. Yujeong Lee
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Lee, Y., Kim, MS. & Lee, J. Neuroprotective strategies to prevent and treat Parkinson’s disease based on its pathophysiological mechanism. Arch. Pharm. Res. 40, 1117–1128 (2017). https://doi.org/10.1007/s12272-017-0960-8

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