![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs12264-022-00963-1/MediaObjects/12264_2022_963_Fig1_HTML.png)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs12264-022-00963-1/MediaObjects/12264_2022_963_Fig2_HTML.png)
References
Delorme R, Ey E, Toro R, Leboyer M, Gillberg C, Bourgeron T. Progress toward treatments for synaptic defects in autism. Nat Med 2013, 19: 685–694.
Guy J, Cheval H, Selfridge J, Bird A. The role of MeCP2 in the brain. Annu Rev Cell Dev Biol 2011, 27: 631–652.
Ariani F, Mari F, Pescucci C, Longo I, Bruttini M, Meloni I. Real-time quantitative PCR as a routine method for screening large rearrangements in Rett syndrome: Report of one case of MECP2 deletion and one case of MECP2 duplication. Hum Mutat 2004, 24: 172–177.
Li XY, **e H, Chen Q, Yu XY, Yi ZS, Li EZ, et al. Clinical and molecular genetic characterization of familial MECP2 duplication syndrome in a Chinese family. BMC Med Genet 2017, 18: 131.
Liu Z, Li X, Zhang JT, Cai YJ, Cheng TL, Cheng C, et al. Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. Nature 2016, 530: 98–102.
Samaco RC, Mandel-Brehm C, McGraw CM, Shaw CA, McGill BE, Zoghbi HY. Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome. Nat Genet 2012, 44: 206–211.
Na ES, Nelson ED, Kavalali ET, Monteggia LM. The impact of MeCP2 loss- or gain-of-function on synaptic plasticity. Neuropsychopharmacology 2013, 38: 212–219.
Yu B, Yuan B, Dai JK, Cheng TL, **a SN, He LJ, et al. Reversal of social recognition deficit in adult mice with MECP2 duplication via normalization of MeCP2 in the medial prefrontal cortex. Neurosci Bull 2020, 36: 570–584.
Yu ZX, Wang DY, Xu XH. Gene editing to the rescue: Reversal of social deficits associated with MECP2 duplication. Neurosci Bull 2020, 36: 567–569.
Delorme A, Makeig S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods 2004, 134: 9–21.
Geng XY, Zhang JG, Jiang Y, Ashkan K, Foltynie T, Limousin P, et al. Comparison of oscillatory activity in subthalamic nucleus in Parkinson’s disease and dystonia. Neurobiol Dis 2017, 98: 100–107.
Cao W, Lin S, **a QQ, du YL, Yang Q, Zhang MY, et al. Gamma oscillation dysfunction in mPFC leads to social deficits in neuroligin 3 R451C knockin mice. Neuron 2018, 98: 670.
Rojas DC, Teale PD, Maharajh K, Kronberg E, Youngpeter K, Wilson LB, et al. Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder. Mol Autism 2011, 2: 11.
Nageshappa S, Carromeu C, Trujillo CA, Mesci P, Espuny-Camacho I, Pasciuto E, et al. Altered neuronal network and rescue in a human MECP2 duplication model. Mol Psychiatry 2016, 21: 178–188.
Acknowledgements
This work was supported by the National Key R&D Program of China (2018YFC1705800), Shanghai Municipal Science and Technology Major Project (2018SHZDZX01), and Shanghai Municipal Science and Technology Major Projects (2021SHZDZX0103 and 2017SHZDZX01).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare no competing interests
Rights and permissions
About this article
Cite this article
Li, X., Nie, Y., Niu, Q. et al. Abnormal Prefrontal Neural Oscillations are Associated with Social Deficits in MECP2 Duplication Syndrome. Neurosci. Bull. 38, 1598–1602 (2022). https://doi.org/10.1007/s12264-022-00963-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12264-022-00963-1