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Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness

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Abstract

A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections (ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients’ outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level.

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Fig. 1: Regions of interest selected in the current study.
Fig. 2: Results of DCM post-hoc selection and one-sample t-tests.
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Acknowledgements

This work was supported by National Natural Science Foundation of China (81471654, 81428013, 81371535, and 81271548), the Natural Science Foundation of Guangdong Province, China (2015A030313609), Planned Science and Technology Project of Guangzhou Municipality, China (20160402007 and 201604020184) and the Innovation Project of The Graduate School of South China Normal University. The authors express appreciation to Drs. Rhoda E. and Edmund F. Perozzi for editing assistance.

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  1. ** Chen and Qiuyou **e have contributed equally to this work.

Authors and Affiliations

  1. Center for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, China

    ** Chen, **aoyan Wu, Huiyuan Huang, Lixiang Chen, Shufei Zhang, Huiqing Hu & Ruiwang Huang

  2. Centre for Hyperbaric Oxygen and Neurorehabilitation, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, 510010, China

    Qiuyou **e, Wei Lv, Yequn Guo & Ronghao Yu

  3. Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, 510515, China

    You Wang

  4. School of Education, Guangzhou University, Guangzhou, 510006, China

    Yangang Nie

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  1. ** Chen
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Correspondence to Ronghao Yu or Ruiwang Huang.

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Chen, P., **e, Q., Wu, X. et al. Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness. Neurosci. Bull. 34, 647–658 (2018). https://doi.org/10.1007/s12264-018-0250-6

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