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Optimal control using linear feedback control and neutralizing antibodies for an HIV model with dynamical analysis

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Abstract

HIV (human immunodeficiency virus) is a dangerous virus that constantly diminishes an individual’s immune system by explicitly targeting CD4 cells, which are the body’s key protectors against disease by obstructing them to make duplicates of themselves. If left untreated, it can lead to AIDS (acquired immunodeficiency syndrome). The Treatment involves antiretroviral therapy which maintains the immunity to a specific level and thus helps in suppressing the virus replication. This paper emphasizes on the development of the model involving healthy and infected population, virus population, antibodies and CTL cells. The investigation encapsulates the local stability based on thresholds followed by the local bifurcation analysis based on \(\beta _1\) and \(R_0\). The global stability analysis is done the using Graph- theoretic approach. Further the optimal control problem is discussed using Linear feedback control method which aims to reduce the viral load by kee** antibodies to a certain level. Numerical discussion includes surface plots of the thresholds based on various parameters, graphs showing the comparison between without control and with control especially for the virus population, infected population and antibodies which are our target. Finally, we have also shown the curve-fitting for our data using optimized Nedlar-Mean algorithm.

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Authors and Affiliations

  1. Department of Mathematics, Amity Institute of Applied Science, Amity University, Sector-125, Noida, India

    Mamta Barik, Sudipa Chauhan & Sumit Kaur Bhatia

  2. School of Mathematics and Allied Sciences, Jiwaji University, Gwalior, 474011, M.P, India

    Om Prakash Misra

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Barik, M., Chauhan, S., Misra, O.P. et al. Optimal control using linear feedback control and neutralizing antibodies for an HIV model with dynamical analysis. J. Appl. Math. Comput. 68, 4361–4389 (2022). https://doi.org/10.1007/s12190-022-01710-5

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