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Successful unrelated bone marrow transplantation for a human immunodeficiency virus type-1-seropositive acute myelogenous leukemia patient following HAART

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Abstract

The availability of highly active anti-retroviral therapy (HAART) has greatly improved the outcome of human immunodeficiency virus type-1 (HIV-1) infection and disease. We report here on a case of an HIV-1-seropositive patient with acute myelogenous leukemia who underwent a successful allogeneic unrelated bone marrow transplantation following HAART. A 40-year-old Japanese HIV-seropositive man underwent allogeneic unrelated bone marrow transplantation using a myeloablative pretransplant-conditioning regimen. Neutrophil engraftment occurred on day +18, and donor chimerism was achieved on day +27. During pre- and post- transplantation, the HAART was not interrupted. Over 1 year after transplantation, the patient is alive and in continuous complete remission with undetectable levels of HIV-1 RNA. HAART can lead to a successful hematopoietic stem cell transplantation without severe opportunistic infections.

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References

  1. Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998;338:853–60.

    Article  PubMed  Google Scholar 

  2. Angelucci E, Lucarelli G, Baronciani D, et al. Bone marrow transplantation in an HIV positive thalassemic child following therapy with azidothymidine. Haematologica. 1990;75:285–7.

    CAS  PubMed  Google Scholar 

  3. Giri N, Vowels MR, Ziegler JB. Failure of allogeneic bone marrow transplantation to benefit HIV infection. J Paediatr Child Health. 1992;28:331–3.

    Article  CAS  PubMed  Google Scholar 

  4. Schneider E, Lambermont M, Voorenv J-P V, et al. Autologous stem cell infusion for acute myeloblastic leukemia in an HIV-1 carrier. Bone Marrow Transplant. 1997;20:611–2.

    Article  CAS  PubMed  Google Scholar 

  5. Gabarre J, Leblond V, Sutton L, et al. Autologous bone marrow transplantation in relapsed HIV-1 related non-Hodgkin’s lymphoma. Bone Marrow Transplant. 1996;18:1195–7.

    CAS  PubMed  Google Scholar 

  6. Re A, Cattaneo C, Michieli M, et al. High-dose therapy and autologous peripheral-blood stem-cell transplantation as salvage treatment for HIV-associated lymphoma in patients receiving highly active antiretroviral therapy. J Clin Oncol. 2003;21:4423–7.

    Article  CAS  PubMed  Google Scholar 

  7. Gabriel I, Apperley J, Bower M, Chaidos A, Gazzard B, Giles C, et al. A long-term durable remission with high-dose therapy autologous stem cell transplant for stage IVB HIV-associated Hodgkins disease. AIDS. 2008;22:539–44.

    Article  PubMed  Google Scholar 

  8. Kang EM, Witte Md, Malech H, Morgan RA, Phang S, Carter C, et al. Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome. Blood. 2002;99:698–701.

    Article  CAS  PubMed  Google Scholar 

  9. Sora F, Antinori A, Picirillo N, De Luca A, Chiusolo P, Cingolani A, et al. Highly active antiretoroviral therapy and allogeneic CD34+ peripheral blood progenitor cells transplantation in an HIV/HCV coinfected patient with acute myeloid leukemia. Exp Hematol. 2002;30:279–84.

    Article  CAS  PubMed  Google Scholar 

  10. Tomonari A, Takahashi S, Shimohakamada Y, Ooi J, Takasugi K, Ohno N, et al. Unrelated cord blood transplantation for a human immunodeficiency virus-1-seropositive patient with acute lymphoblastic leukemia. Bone Marrow Transplant. 2005;36:261–2.

    Article  CAS  PubMed  Google Scholar 

  11. Wolf T, Rickerts V, Staszewski S, Kriener S, Wassmann B, Bug G, et al. First case of successful allogeneic stem cell transplantation in an HIV-patient who acquired sever aplastic anemia. Haematologica. 2007;92:e56–8.

    Article  CAS  PubMed  Google Scholar 

  12. Woolfrey AE, Malhotra U, Harrington RD, McNevin J, Manley TJ, Riddell SR, et al. Generation of HIV-1-specific CD8+ cell responses following allogeneic hematopoietic cell transplantation. Blood. 2008;112:3484–7.

    Article  CAS  PubMed  Google Scholar 

  13. Monfardini S, Vaccher E, Pizzocaro G, et al. Unusual malignant tumors with HIV infection. AIDS. 1989;3:449–52.

    Article  CAS  PubMed  Google Scholar 

  14. Biggar RJ, Curtis RE, Cote TR, Rabkin CS, Melbye M. Risk of other cancers following Kaposi’s sarcoma: relation to acquired immunodeficiency syndrome. Am J Epidemiol. 1994;139:362–8.

    CAS  PubMed  Google Scholar 

  15. Sutton L, Guenel P, Tanguy M-L, Rio B, Dhedin N, Casassus P, et al. Acute myeloid leukaemia in human immunodeficiency virus-infected adults: epidemiology, treatment feasibility and outcome. Br J Hematol. 2001;112:900–8.

    Article  CAS  Google Scholar 

  16. Miyawaki S, Sakamaki H, Ohtake S, et al. A randomized, postremission comparison of four courses of standard-dose consolidation therapy without maintenance therapy versus three courses of standard-dose consolidation with maintenance therapy in adults with acute myeloid leukemia: the Japan Adult Leukemia Study Group AML 97 Study. Cancer. 2005;104:2726–34.

    Article  CAS  PubMed  Google Scholar 

  17. Thiede C, Steudel C, Mohr B, Schaich M, Schakel U, Wermke MW, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtype and identification of subgroup with poor prognosis. Blood. 2002;99:4326–35.

    Article  CAS  PubMed  Google Scholar 

  18. Koga I, Odawara T, Matsuda M, Sugiura W, Goto M, Nakamura T, et al. Analysis of HIV-1 sequences before and after co-infecting syphilis. Microbes Infect. 2006;8:2872–9.

    Article  CAS  PubMed  Google Scholar 

  19. Miura T, Brockman MA, Brumme CJ, Brumme ZL, Carlson JM, Pereyra F, et al. Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes. J Virol. 2008;82:8422–30.

    Article  CAS  PubMed  Google Scholar 

  20. Krishnan A, Zaia J, Forman SJ. Should HIV-positive patients with lymphoma be offered stem cell transplants? Bone Marrow Transplant. 2003;32:741–8.

    Article  CAS  PubMed  Google Scholar 

  21. Antinori A, Cingolani A, Alba L, Ammassari A, Serraino D, Ciancio BC, et al. Better response to chemotherapy and prolonged survival in AIDS-related lymphomas responding to highly active antiretroviral therapy. AIDS. 2001;15:1483–91.

    Article  CAS  PubMed  Google Scholar 

  22. Ratner L, Lee J, Tang S, Redden D, Hamzeh F, Herndier B, et al. Chemotherapy for human immunodeficiency virus-associated non-Hodgkin’s lymphoma in combination with highly active antiretroviral therapy. J Clin Oncol. 2001;19:2171–8.

    CAS  PubMed  Google Scholar 

  23. Gupta V, Tomblyon M, Pedersen TL, Atkins HL, Battiwalla M, Gress RE, et al. Allogeneic hematopoietic cell transplantation in human immunodeficiency virus-positive patients with hematologic disorders: a report from the center for international blood and marrow transplant research. Biol Blood Marrow Transpl. 2009;15:864–71.

    Article  Google Scholar 

  24. Schlegel P, Beaty P, Halvorsen P, McCune J. Successful allogeneic bone marrow transplant in an HIV-1-positive man with chronic myelogeneous leukemia. J AIDS. 2000;24:289–90.

    CAS  Google Scholar 

  25. Hütter G, Nowak D, Mossner M, Ganepola S, Müβig A, Allers K, et al. Long-term control of HIV by CCR5 delta32/delta32 stem cell transplantation. N Engl J Med. 2009;360:692–8.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8606, Japan

    Yoko Oka, Ichiro Koga & Shin Fujimori

  2. Department of Hematology/Oncology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8606, Japan

    Yoko Oka, Haruko Tashiro, Mitsuho Mizutani-Noguchi, Toshihiko Sugao, Ryosuke Shirasaki, Nobu Akiyama, Kazuo Kawasugi & Naoki Shirafuji

  3. Department of Infectious Disease Control, International Research Center for Infectious Disease, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8606, Japan

    Toshiyuki Miura

Authors
  1. Yoko Oka
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  2. Haruko Tashiro
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  3. Mitsuho Mizutani-Noguchi
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  4. Ichiro Koga
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  5. Toshihiko Sugao
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  6. Ryosuke Shirasaki
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  7. Toshiyuki Miura
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  8. Nobu Akiyama
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  9. Kazuo Kawasugi
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  10. Shin Fujimori
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  11. Naoki Shirafuji
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Corresponding author

Correspondence to Naoki Shirafuji.

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Oka, Y., Tashiro, H., Mizutani-Noguchi, M. et al. Successful unrelated bone marrow transplantation for a human immunodeficiency virus type-1-seropositive acute myelogenous leukemia patient following HAART. Int J Hematol 91, 140–145 (2010). https://doi.org/10.1007/s12185-009-0467-2

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  • DOI: https://doi.org/10.1007/s12185-009-0467-2

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