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Negative Emotions in End-Stage Renal Disease: Are Anxiety Symptoms Related to Levels of Circulating Catecholamines?

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Abstract

The purpose of this study was to assess depression and anxiety levels and possible correlations with levels of circulating catecholamines in maintenance hemodialysis (MHD) and Conservative care (CC) ERSD patients. Eighty ESRD patients, forty treated by MHD and forty by CC, were included in the study. Circulating catecholamines concentrations were measured; all subjects were assessed by Hamilton Rating Scale for Depression, Hamilton Rating Scale for Anxiety, Self-Rating Depression Scale, and Self-Rating Anxiety Scale. Statistical analysis showed significant differences in Noradrenaline (p < 0.0001), higher in the CC group, and Dopamine (p = 0.002), higher in MHD subjects. Moreover, significant differences were documented regarding the anxiety variables (HRSA: p = 0.007; SAS: p = 0.007), all higher in CC group; no significant differences were documented on depression variables. Finally, linear regression analysis indicated that only noradrenaline was a strongest predictor of anxiety (HRSA: p = 0.003; SAS: p < 0.0001). ESRD patients showed a heightened vulnerability to anxiety. Given the concerns with pharmacologic treatment of emotional disturbances in patients with ESRD, the priority should be given to psychological interventions and preventive approaches aimed to address the early appearance of anxiety symptoms.

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Acknowledgments

The Authors thank all the patients of the Nephrology Unit for their availability to participate in the study, and the whole staffs of the Psychiatry and Nephrology Units, University Hospital of Messina, Italy, for assistance with recruitment and data collection.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Nephrology Unit, Department of Clinical and Experimental Medicine, Policlinico Universitario, Via Consolare Valeria 1, Contesse, 98125, Messina, Italy

    Michele Buemi, Eleonora Di Mauro, Domenico Santoro & Valeria Cernaro

  2. Psychiatry Unit, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Policlinico Universitario, Via Consolare Valeria 1, Contesse, 98125, Messina, Italy

    Antonio Bruno, Francesca Cordova, Veronica Currò, Gianluca Pandolfo, Maria Rosaria Anna Muscatello & Rocco Antonio Zoccali

  3. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Policlinico Universitario, Via Consolare Valeria 1, Contesse, 98125, Messina, Italy

    Maria Rosaria Anna Muscatello

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  1. Michele Buemi
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  3. Francesca Cordova
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  4. Veronica Currò
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  9. Maria Rosaria Anna Muscatello
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  10. Rocco Antonio Zoccali
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Corresponding author

Correspondence to Maria Rosaria Anna Muscatello.

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Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee, and with the 1964 Helsinki declaration and its later amendments, or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Conflict of Interest

Michele Buemi declares that he has no conflict of interest. Antonio Bruno declares that he has no conflict of interest. Francesca Cordova declares that she has no conflict of interest. Veronica Currò declares that she has no conflict of interest. Eleonora Di Mauro declares that she has no conflict of interest. Domenico Santoro declares that he has no conflict of interest. Valeria Cernaro declares that she has no conflict of interest. Gianluca Pandolfo declares that he has no conflict of interest. Maria Rosaria Anna Muscatello declares that she has no conflict of interest. Rocco Antonio Zoccali declares that he has no conflict of interest.

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Buemi, M., Bruno, A., Cordova, F. et al. Negative Emotions in End-Stage Renal Disease: Are Anxiety Symptoms Related to Levels of Circulating Catecholamines?. Curr Psychol 39, 729–735 (2020). https://doi.org/10.1007/s12144-018-9796-8

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