Abstract
The study aims to evaluate the long-term outcomes − functional, pulmonary and non-pulmonary (other organs) − in children hospitalized with COVID-19 infection or with Multisystem inflammatory syndrome (MIS-C) after 1–2 y of discharge. All children with moderate or severe COVID-19 or MIS-C were enrolled. Out of 45 enrolled subjects, 19.8% had COVID-19 infection and 82% had MIS-C. Four children (8.9%) had abnormal baseline echocardiography; two each with cardiac dysfunction and coronary dilatation. At baseline, 44% had moderate disability and 24% had mild disability as per Pediatric Cerebral Performance Category (PCPC). On follow-up, only 8.9% (n = 4) had mild and 2.2% (n = 1) had moderate disability as per the PCPC score. One child developed new onset tuberculosis of the bone. None had any pulmonary morbidities. Follow-up echocardiogram was also within normal limits for children with abnormal findings. Further studies in different populations (settings) are required to draw meaningful conclusions about long-term effects of COVID-19 on children.
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References
Yong SJ. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infect Dis. 2021;53:737–54.
Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, et al. A clinic blueprint for post-coronavirus disease 2019 RECOVERY: learning from the past, looking to the future. Chest. 2021;159:949–58.
Ludvigsson JF. Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19. Acta Paediatr. 2021;110:914–21.
Carfì A, Bernabei R, Landi F; Gemelli Against COVID-19 Post-Acute Care Study Group. Persistent symptoms in patients after acute COVID-19. JAMA. 2020;324:603–5.
Nalbandian A, Sehgal K, Gupta A, et al. Post-acute COVID-19 syndrome. Nat Med. 2021;27:601–15.
Centers for Disease Control and Prevention. Information for healthcare providers about multisystem inflammatory syndrome in children (MIS-C). 2021. Available at: https://www.cdc.gov/mis-c/hcp/. Accessed on 26 March 2021.
Behnood SA, Shafran R, Bennett SD, et al. Persistent symptoms following SARS-COV-2 infection amongst children and young people: a meta-analysis of controlled and uncontrolled studies. J Infect. 2022;84:158–70.
Borch L, Holm M, Knudsen M, Ellermann-Eriksen S, Hagstroem S. Long covid symptoms and duration in SARS-COV-2 positive children — a nationwide cohort study. Eur J Pediatr. 2022;181:1597–607.
Feldstein LR, Tenforde MW, Friedman KG, et al. Characteristics and outcomes of US children and adolescents with multisystem inflammatory syndrome in children (MIS-C) compared with severe acute COVID-19. JAMA. 2021;325:1074–87.
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Institute Research Grant No.F.5–59/IRG/2010/RS.
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AT, JS were responsible for develo** the research questions; RS, AT, HB, NKB, JS were responsible for the study design and collection of data; NKB, JS, RL were responsible for study management and coordination; RS, AT, JS were responsible for the analysis of the data. All authors read, commented on, and approved the final manuscript. JS will act as guarantor for this manuscript.
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Singla, R., Sankar, J., Tayal, A. et al. Long-Term Outcomes of Survivors of COVID-19 with Moderate to Severe Infection and Children with Multisystem Inflammatory Syndrome or MIS-C. Indian J Pediatr (2024). https://doi.org/10.1007/s12098-024-05033-0
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DOI: https://doi.org/10.1007/s12098-024-05033-0