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Myofibroma with Atypical Features can Mimic Low-Grade Myofibroblastic Sarcoma: Two Paediatric Cases

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Myofibroma is a rare benign mesenchymal tumor that frequently affects the pediatric population with a predilection for the head and neck region. About 10% of myofibroma cases, presenting atypical features, can be misinterpreted as low-grade myofibroblastic sarcoma (LGMS), with therapeutic and prognostic impact. Here, we report two pediatric cases of benign myofibroblastic tumors, one of them showing typical characteristics of myofibroma, the other was an atypical myofibroma, which initially mimicked low-grade myofibroblastic sarcoma. Atypical myofibromas, despite its distinctive characteristics, follow a benign course, similar with typical myofibroma. It is necessary to distinguish atypical myofibroma from low-grade myofibroblastic sarcoma and avoid unnecessary invasive therapy.

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Data sharing is not applicable to this article as no new data were created or analyzed in this study.

References

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Funding

Jorge Esquiche León have received research Grants (2016/11419-0; 2022/07479-9 and 2022/12760-9) from State of São Paulo Research Foundation (FAPESP) and research Grant (304241/2021-0) from National Council for Scientific and Technological Development (CNPq), Brazil.

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Authors and Affiliations

  1. Department of Pediatric Dentistry, Ribeirão Preto Dental School, University of São Paulo (USP), Ribeirão Preto, Brazil

    Magdalena Raquel Torres Reyes, Karina Helen Martins & Gabriela Esperanza Maradiaga Posantes

  2. Department of Pathology and Diagnosis, School of Dentistry, University of El Salvador, San Salvador, El Salvador

    Florence Juana Maria Cuadra Zelaya & Sandra Guadalupe Góngora Renderos

  3. Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Av Do Café, S/n Campus USP, Ribeirão Preto, São Paulo, CEP: 14040-904, Brazil

    Jorge Esquiche León

  4. Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, Brazil

    Jorge Esquiche León

Authors
  1. Magdalena Raquel Torres Reyes
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  2. Karina Helen Martins
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  3. Gabriela Esperanza Maradiaga Posantes
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  4. Florence Juana Maria Cuadra Zelaya
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  5. Sandra Guadalupe Góngora Renderos
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  6. Jorge Esquiche León
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Contributions

All authors: Magdalena Raquel Torres Reyes, Karina Helen Martins, Gabriela Esperanza Maradiaga Posantes, Florence Juana Maria Cuadra Zelaya, Sandra Guadalupe Góngora Renderos and Jorge Esquiche León contributed to the study conception and design. Material preparation, data collection and analysis were performed by all the authors. All authors contributed to the organization and manuscript drafting, read and approved the final manuscript.

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Correspondence to Jorge Esquiche León.

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Reyes, M.R.T., Martins, K.H., Posantes, G.E.M. et al. Myofibroma with Atypical Features can Mimic Low-Grade Myofibroblastic Sarcoma: Two Paediatric Cases. Indian J Otolaryngol Head Neck Surg (2024). https://doi.org/10.1007/s12070-024-04828-z

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  • DOI: https://doi.org/10.1007/s12070-024-04828-z

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