Abstract
Extranodal NK/T-cell lymphoma, nasal type (ENKL) is a rare nasal pathology, which in the past was grouped with list of granulomatous diseases. It is an aggressive non-Hodgkin’s lymphoma characterized clinically by a non-relenting destruction of the midline structures of the palate and nasal cavity. Despite the malignant clinical nature, tissue diagnosis may be difficult due to extensive tissue necrosis mandating multiple biopsies and has an ominous prognosis, as the average survival rate lying between 6 and 25 months as in large number of Asian studies. This is the case report of a 60-year-old female who presented with (L) nasal obstruction and recurrent episodes of rhinosinusitis for last 8 months, which had been treated with antibiotics, anti-inflammatory drugs and intranasal corticosteroids without success. After performing battery of tests, diagnosed histologically and confirmed by immunohistochemical analysis that the patient had an ENKL, nasal type (AKA angiocentric T-cell lymphoma).
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs12070-023-03610-x/MediaObjects/12070_2023_3610_Fig1_HTML.jpg)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs12070-023-03610-x/MediaObjects/12070_2023_3610_Fig2_HTML.jpg)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs12070-023-03610-x/MediaObjects/12070_2023_3610_Fig3_HTML.jpg)
Similar content being viewed by others
References
Metgud RS, Doshi JJ, Gaurkhede S, Dongre R, Karle R (2011) Extranodal NK/T-cell lymphoma, nasal type (angiocentric T-cell lymphoma): a review about the terminology. J Oral MaxillofacPathol 15:96–100
Mc BP (1897) Photographs of a case of rapid destruction of the nose and face. J Laryngol Otol 12:64–66. https://doi.org/10.1017/S0022215100118407
Ishii Y, Yamanaka N, Ogawa K, Yoshida Y, Takami T, Matsuura A, Isago H, Kataura A, Kikuchi K (1982) Nasal T-cell lymphoma as a type of so-called “lethal midline granuloma.” Cancer 50(11):2336–2344. https://doi.org/10.1002/1097-0142(19821201)50:11%3c2336::aid-cncr2820501120%3e3.0.co;2-c. (PMID: 6754065)
Chan JK, Sin VC, Wong KF, Ng CS, Tsang WY, Chan CH, Cheung MM, Lau WH (1997) Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm. Blood 89(12):4501–4513 (PMID: 9192774)
The 5th edition of the world health organization classification of haematolymphoid tumors: lymphoid neoplasms
Allen PB, Jo Lechowicz M (2019) Management of NK/T-cell lymphoma, nasal type. J Oncol Pract 15(10):513–520
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
The authors declare that they have no conflict of interest.
Informed consent
Informed consent was taken from the patient for the case report.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Biradar, K., Bishnoi, T., Sahu, P.K. et al. Primary Non-Hodgkin's Lymphoma of the Nose: A Rare Case Report. Indian J Otolaryngol Head Neck Surg 75 (Suppl 1), 1069–1071 (2023). https://doi.org/10.1007/s12070-023-03610-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12070-023-03610-x