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Microwave-promoted multi-component and green synthesis of thiadiazolo[3,2-a]pyrimidines under solvent-free conditions

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Abstract

This research is aimed at synthesizing pyrimidine heterocycles that contain 1,3,4-thiadiazole ring moiety by microwave-assisted multi-component reactions. For this purpose, synthesizing of [1,3,4] thiadiazolo[3,2-a]pyrimidine-6-carboxylate derivatives was carried out in a single-step reaction using aromatic aldehydes, ethyl acetoacetate, and different derivatives of 1,3,4-thiadiazoles (with molar ratio of 1:2:1 respectively) in the presence of [Et3NH]+[HSO4]- ionic liquid, under solvent-free conditions.

Graphical abstract

This research, synthesis of [1,3,4] thiadiazolo[3,2-a]pyrimidine-6-carboxylate derivatives was carried out in a single-step reaction using aromatic aldehydes, ethyl acetoacetate and different derivatives of 1,3,4-thiadiazoles (with molar ratio of 1:2:1, respectively) in the presence of [Et3NH]+[HSO4]- ionic liquid under solvent-free microwave irradiation.

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Acknowledgements

The authors express appreciation to Qom University of Technology for supporting this investigation.

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Authors and Affiliations

  1. Department of Organic Chemistry, Qom University of Technology, Qom, 37195, Iran

    Behjat Pouramiri

  2. Faculty of Sciences, Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, 76169, Iran

    Mohsen Rashidi

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  1. Behjat Pouramiri
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Correspondence to Behjat Pouramiri.

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Pouramiri, B., Rashidi, M. Microwave-promoted multi-component and green synthesis of thiadiazolo[3,2-a]pyrimidines under solvent-free conditions. J Chem Sci 135, 97 (2023). https://doi.org/10.1007/s12039-023-02217-7

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  • DOI: https://doi.org/10.1007/s12039-023-02217-7

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