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Activation of Inflammasomes and Relevant Modulators for the Treatment of Microglia-mediated Neuroinflammation in Ischemic Stroke

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Abstract

As the brain’s resident immune patrol, microglia mediate endogenous immune responses to central nervous system injury in ischemic stroke, thereby eliciting either neuroprotective or neurotoxic effects. The association of microglia-mediated neuroinflammation with the progression of ischemic stroke is evident through diverse signaling pathways, notably involving inflammasomes. Within microglia, inflammasomes play a pivotal role in promoting the maturation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), facilitating pyroptosis, and triggering immune infiltration, ultimately leading to neuronal cell dysfunction. Addressing the persistent and widespread inflammation holds promise as a breakthrough in enhancing the treatment of ischemic stroke.

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Funding

This work was supported by the Natural Science Foundation of Jiangsu Province (Grant number is BK20221527) and Jiangsu Qing Lan Project (2022).

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  1. State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nan**g, 211198, China

    Ze-Jie Zeng, **aobing Lin, Liu Yang, Yi Li & Wen Gao

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  2. **aobing Lin
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  3. Liu Yang
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  4. Yi Li
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  5. Wen Gao
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All authors contributed to the study conception and design. Material preparation and data collection were performed by Ze-Jie Zeng, **aobing Lin, and Liu Yang. The drafts of the manuscript were written by Ze-Jie Zeng, and all authors commented on previous versions of the manuscript. All authors approved the final manuscript.

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Correspondence to Yi Li or Wen Gao.

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Zeng, ZJ., Lin, X., Yang, L. et al. Activation of Inflammasomes and Relevant Modulators for the Treatment of Microglia-mediated Neuroinflammation in Ischemic Stroke. Mol Neurobiol (2024). https://doi.org/10.1007/s12035-024-04225-1

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