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Correlation Between Serum 1,25(OH)2D3, Serum Phosphorus, and Parathyroid Hormone and Parathyroid Function After Central Lymph Node Dissection in Patients with Papillary Thyroid Carcinoma

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Abstract

This work was to demonstrate the relationship between serum 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), serum phosphorus (SP), and parathyroid hormone (PTH) and parathyroid function after central lymph node dissection (CLND) in patients with papillary thyroid carcinoma (PTC). 200 PTC patients after CLND were included, who were rolled into a control group (CG) (n = 89 cases without hypoparathyroidism) and an observation group (OG) (n = 111 cases with complicated hypoparathyroidism). The 1,25(OH)2D3, SP, and PTH levels were detected, and the diagnostic effect of these indicators was assessed. The serum PTH levels of patients in CG after surgery were normal relative to those before surgery, while the serum PTH of patients in OG was relatively lower. 1,25(OH)2D3 concentration of patients in OG was also inferior to CG, while the SP level was superior (P < 0.05). Hypoparathyroidism was positively correlated with serum PTH (r = 0.382) and 1,25(OH)2D3 (r = 0.321) and negatively correlated with SP (r =  − 0.211). The area under the curve (AUC) (0.893), sensitivity (90.83%), and specificity (94.77%) of the joint diagnosis of 1,25(OH)2D3 + SP + PTH were greatly superior to those of the single diagnosis and the pairwise diagnosis with the three indicators (P < 0.05). Hypoparathyroidism in patients with PTC after CLND surgery was positively correlated with 1,25(OH)2D3 and PTH and negatively correlated with SP concentration. In addition, the combination diagnosis of 1,25(OH)2D3, PTH, and SP worked well.

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Data Availability

All data generated or analysed during this study are included in this published article.

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Acknowledgements

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Funding

The research is supported by: Hongmei Yu, Zhejiang Medical and Health Technology Project, Diagnosis of parathyroid function after central lymph node dissection and neck lymph node dissection using 1,25- (OH) 2-D3 combined with blood calcium and parathyroid hormone, respectively, (No.: 2023XY192). Weiwei Su, Zhejiang Medical and Health Technology Project, Thyroid surgery through the anterior margin of the lateral cervical sternocleidomastoid muscle approach, (No. 2023XY187).

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  1. Hongmei Yu and Haiqiang Li have contributed equally to this work as co-first author.

Authors and Affiliations

  1. Department of Thyroid and Breast Surgery, Tongxiang First People’s Hospital, Zhejiang Province, Jiaxing, 314500, China

    Hongmei Yu, Haiqiang Li, Weiwei Su, Zhiwei Xu, Mengqi Xu, Chen Hang & ** Li

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  1. Hongmei Yu
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HY, HL, WS, ZX, MX, CH and XL analyzed data and writing, participated in collection of data and experimental operations, participated in design testing and supervision testing. All authors read and approve the manuscript version final.

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Correspondence to ** Li.

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The study was approved by the local ethics committee of the Tongxiang First People’s Hospital. All experiments were performed in accordance with relevant guidelines and regulations such as the Declaration of Helsinki and the patients signed the informed consent form and agreed to be published.

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Yu, H., Li, H., Su, W. et al. Correlation Between Serum 1,25(OH)2D3, Serum Phosphorus, and Parathyroid Hormone and Parathyroid Function After Central Lymph Node Dissection in Patients with Papillary Thyroid Carcinoma. Mol Biotechnol (2024). https://doi.org/10.1007/s12033-024-01147-0

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