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Novel Strategies to Combat Bacterial Biofilms

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Abstract

Biofilms are considered as a severe problem in the treatment of bacterial infections; their development causes some noticeable resistance to antibacterial agents. Biofilms are responsible for at least two-thirds of all infections, displaying promoted resistance to classical antibiotic treatments. Therefore, finding new alternative therapeutic approaches is essential for the treatment and inhibition of biofilm-related infections. Therefore, this review aims to describe the potential therapeutic strategies that can inhibit bacterial biofilm development; these include the usage of antiadhesion agents, AMPs, bacteriophages, QSIs, aptamers, NPs and PNAs, which can prevent or eradicate the formation of biofilms. These antibiofilm agents represent a promising therapeutic target in the treatment of biofilm infections and development of a strong capability to interfere with different phases of the biofilm development, including adherence, polysaccharide intercellular adhesion (PIA), quorum sensing molecules and cell-to-cell connection, bacterial aggregation, planktonic bacteria killing and host-immune response modulation. In addition, these components, in combination with antibiotics, can lead to the development of some kind of powerful combined therapy against bacterial biofilm-related infections.

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Authors and Affiliations

  1. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Fatemeh Hemmati, Leila Yousefi & Roghayeh Nouri

  2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Fatemeh Hemmati, Mohammad Ahangarzadeh Rezaee & Roghayeh Nouri

  3. Department of Food Science and Technology, Faculty of Agriculture and Natural Resources, Urmia University, Urmia, Iran

    Saba Ebrahimzadeh

  4. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Leila Yousefi, Hossein Samadi Kafil & Pourya Gholizadeh

Authors
  1. Fatemeh Hemmati
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  2. Mohammad Ahangarzadeh Rezaee
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  3. Saba Ebrahimzadeh
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  4. Leila Yousefi
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  5. Roghayeh Nouri
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  6. Hossein Samadi Kafil
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  7. Pourya Gholizadeh
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Contributions

FH: Conceptualization; Data curation; Formal analysis; Investigation; Methodology; Roles/Writing—original draft; Writing—review & editing. MAR, SE, LY, RN & HSK: Data curation; Roles/Writing—original draft; Writing—review & editing. PG: Project administration; Resources; Software; Supervision; Validation; Visualization; Writing—review & editing.

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Correspondence to Pourya Gholizadeh.

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Hemmati, F., Rezaee, M.A., Ebrahimzadeh, S. et al. Novel Strategies to Combat Bacterial Biofilms. Mol Biotechnol 63, 569–586 (2021). https://doi.org/10.1007/s12033-021-00325-8

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  • DOI: https://doi.org/10.1007/s12033-021-00325-8

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