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Serum fetuin B level increased in subjects of nonalcoholic fatty liver disease: a case-control study

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Abstract

Fetuin is an endogenous inhibitor of the insulin receptor tyrosine kinase. Recent studies supported the possible role of fetuin B in metabolic diseases. This study is to evaluate the role of serum fetuin B in nonalcoholic fatty liver disease (NAFLD). A hospital-based case-control study of 184 subjects was conducted. Serum level of fetuin B was measured by enzyme-linked immunosorbent assay. The serum level of fetuin B in the control (91.0 ± 36.9 μg/ml) was lower than it in NAFLD (108.7 ± 38.5 μg/ml, P < 0.001). The percentage of NAFLD increased (42.9%, 58.7% and 60.2%; P < 0.001; linear-by-linear association: P < 0.001), as fetuin B concentration elevated in its tertiles, after adjustment of body mass index (BMI). Furthermore, compared with the 1st tertile, the 3rd tertile of fetuin B indicated an association with the presence of NAFLD (adjusted odds ratio = 2.087, 95% confidence interval [1.016 – 3.937], P = 0.023), after controlling age, sex, BMI, diabetes, hypertension and hypertriglyceridemia. Lastly, fetuin B correlated with diastolic blood pressure, serum alanine transaminase and triglycerides, among the controls. It suggested a potential association between serum fetuin B and the presence of NAFLD.

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Acknowledgments

This study is supported by National Key Basic Research Development Program (No. 2012CB524905), National Science and Technology Support Plan Project (No. 2012BAI06B04), National Natural Science Foundation of China (No. 81170378 and No. 81230012).

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Authors and Affiliations

  1. Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, China

    **zhou Zhu, **ngyong Wan, Yuming Wang, Chunxiao Li, Chaohui Yu & Youming Li

  2. The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310003, Zhejiang Province, China

    Kefu Zhu

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  1. **zhou Zhu
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Correspondence to Youming Li.

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Zhu, J., Wan, X., Wang, Y. et al. Serum fetuin B level increased in subjects of nonalcoholic fatty liver disease: a case-control study. Endocrine 56, 208–211 (2017). https://doi.org/10.1007/s12020-016-1112-5

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  • DOI: https://doi.org/10.1007/s12020-016-1112-5

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