Abstract
The contribution of air pollution-induced cardiopulmonary damage on the development of hypertensive disorders of pregnancy and other adverse outcomes of pregnancy has gained increased attention as epidemiological data continue to highlight spatiotemporal pregnancy trends related to air pollution exposure. However clinical mechanistic data surrounding gestational complications remain sparse, necessitating the need for the use of animal models to study these types of complications of pregnancy. The current study seeks to examine the real-time effects of mid-gestational ozone exposure on maternal blood pressure and body temperature through the use of radiotelemetry in a rat model. The exposure resulted in acute depression of heart rate and core body temperature as compared to control animals. Ozone-exposed animals also presented with a slight but significant increase in arterial blood pressure which was perpetuated until term. The data presented here illustrates the feasibility of murine models to assess cardiovascular complications caused by inhaled toxicants during the window of pregnancy.
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Acknowledgements
This research was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (F31 HD107945), the National Institute of Environmental Health Sciences (R01 ES014639), and the National Institute for General Medical Sciences (P20 GM130422).
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All authors read and approved the manuscript. Major writing was conducted by RH, NLK, BB, and MC. Surgical procedures were conducted by CP, TW, and RH Exposures were conducted by SL. Data collection and analysis were conducted by RH, DL, and MC. Study design and conceptualization was conducted by TW, RH, AO, MC, RA, and NLK
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Hunter, R., Wilson, T., Lucas, S. et al. Characterization of Mild Delayed Gestational Hypertension in Rats Following Ozone Exposure. Cardiovasc Toxicol (2024). https://doi.org/10.1007/s12012-024-09887-w
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DOI: https://doi.org/10.1007/s12012-024-09887-w