Abstract
Previous studies reported that iron may have an indispensable role in the risk of hypertension (HTN). However, the result of the studies on the relationship between iron and risk of HTN is inconsistent. This study aimed to assess the association between the association of dietary iron intake and HTN in the Iranian population. This case–control study was conducted on 4184 people aged 35 to 70, including 1239 people with HTN and 2945 people with normal blood pressure (BP) in Sabzevar, Iran. Dietary intake was assessed using a food frequency questionnaire (FFQ). The Nutritionist IV software was used in terms of the assessment of dietary intake of iron. An inverse association was found between iron intake and HTN (OR = 0.97, CI 95%: 0.94–0.99, P = 0.04). The association remained significant after adjustment for age, gender, smoking, drinking alcohol, calorie intake, and BMI (OR = 0.94, CI 95%: 0.89–0.98, P = 0.01). As a conclusion, iron intake was inversely associated with HTN. Further longitudinal studies on the effect of iron intake on BP are required to confirm this finding.
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Datasets used and/or analyzed during the current study are available from the corresponding author on reasonable requests.
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Acknowledgements
We are thankful to Sabzevar University of Medical Sciences, Sabzevar, Iran for their excellent supports.
Funding
This study is financially supported by the Sabzevar University of Medical Sciences, Sabzevar, Iran (Code 403000). Thanks to all the colleagues in the research committee for their nice cooperation.
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AR, MT, FA, AT, MKM, AK, HSH and SD designed the study, involved in the data collection, analysis, and drafting of the manuscript. SD, PB, MKH and MGH were involved in the design of the study, analysis of the data, and critically reviewed the manuscript. All authors read and approved the final manuscript.
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All methods were carried out in accordance with relevant guidelines and regulations Ethical Committee of the Research Ethics Committee of the sabzevar University of Medical Sciences, Sabzevar, Iran. (code: IR.MEDSAB.REC.1400.021). All procedures of the studies involving human participants were by the ethical standards of the institutional and/or national research committee and the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. All participants signed informed consent forms. Informed consent was obtained from the adolescents and their parents to participate in the study.
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Mousavi Mele, M., Tahavorgar, A., Salimi, Z. et al. The Association of Iron Intake and Hypertension, Does Iron Intake Decrease Blood Pressure?. Cardiovasc Toxicol 24, 345–350 (2024). https://doi.org/10.1007/s12012-024-09848-3
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DOI: https://doi.org/10.1007/s12012-024-09848-3