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Serum Cadmium and Lead Levels in Thalassemic Patients of Najaf Governorate, Iraq

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Abstract

Thematological is a class of hereditary hematologic illnesses resulting from abnormalities in the production of one or more hemoglobin chains. Patients with β-Thematological may have a reduction in heavy metal levels as a result of iron chelate medication. The aim is to study the levels of heavy metals (toxic) in the blood of beta-Thematological patients and compare them to healthy people for the purpose of arriving at indicators through which it is possible to assist in early diagnosis of this disease or reduce symptoms. The study included 80 patients in comparison with age- and gender-matched 40 healthy individuals as controls. Samples were gathered between July 1, 2023, and September 1, 2023. The patients were interviewed for socio-demographic variables, and their medical histories were obtained from the hospital files. Cadmium and lead concentrations were determined using flame atomic absorption spectrometry (FAAS). All samples from Thematological patients were taken after the chelating therapy. Cadmium levels in Thematological patients were found to be lower in both genders in the control group. Lead levels were found to be greater in male Thematological patients and lower in female Thematological patients than those in the control group of female Thematological patients. Additionally, it was observed that patients from areas outside of Najaf’s city center had greater levels of lead and cadmium than patients from the city center. Cadmium and lead levels in the serum were often low in Thematological patients. Heavy metals are eliminated when deferasirox chelate is taken.

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No datasets were generated or analyzed during the current study.

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Acknowledgements

We would like to express our warm thanks and praise to the University of Kufa, Iraq, for the support and facilities it provides to researchers. Especially the laboratory of the physics department at the College of Science for their support.

Funding

The study was performed without external funding.

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Authors and Affiliations

  1. Faculty of Dentistry, University of Kufa, Najaf, Iraq

    Noor Hassan Abdulrudha

  2. Department of Physics, Faculty of Science, University of Kufa, Najaf, Iraq

    Shaymaa Awad Kadhim

Authors
  1. Noor Hassan Abdulrudha
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  2. Shaymaa Awad Kadhim
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Contributions

S.A. wrote the main manuscript text, and treat the results statistically and references, N.H collected the samples, prepared Figs. 1, 2, 3, and 4, and prepared Tables 1, 2, and 3, and all authors reviewed the manuscript.

Corresponding author

Correspondence to Shaymaa Awad Kadhim.

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The local ethics commission gave its approval to the study protocol.

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The authors declare no competing interests.

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Abdulrudha, N.H., Kadhim, S.A. Serum Cadmium and Lead Levels in Thalassemic Patients of Najaf Governorate, Iraq. Biol Trace Elem Res (2024). https://doi.org/10.1007/s12011-024-04184-7

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