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Dietary Dihydromyricetin Zinc Chelate Supplementation Improves the Intestinal Health of Magang Geese

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Abstract

To fulfill the nutritional requirements of poultry, effective Zn supplementation is required due to Zn deficiency in basic feed. In this study, we investigated the effects of DMY-Zn (dihydromyricetin zinc chelate) on the growth performance, morphology, and biochemical indices; the expression of intestinal barrier-related genes; the intestinal microflora; and the cecum metabolome of Magang geese. A total of 300 14-day-old Magang geese (equal number of males and females) with an average body weight of 0.82 ± 0.08 kg were randomly divided into five groups and fed a basal diet; these groups were given DMY-Zn (low, medium, or high level of DMY-Zn with 30, 55, or 80 mg/kg Zn added to the basal diet) or ZnSO4 (80 mg/kg Zn added) for 4 weeks. Our results revealed that DMY-Zn significantly impacts growth and biochemical indices and plays a significant role in regulating the intestinal barrier and microflora. DMY-Zn is involved in the upregulation of intestinal barrier gene (ZO1 and MUC2) expression, as well as upregulated Zn-related gene expression (ZIP5). On the other hand, a low concentration of DMY-Zn increased the ɑ diversity index and the abundance of Lactobacillus and Faecalibacterium. Additionally, a cecal metabolomics study showed that the main metabolic pathways affected by DMY-Zn were the pentose phosphate pathway, the biosynthesis of different alkaloids, and the metabolism of sphingolipids. In conclusion, DMY-Zn can reduce feed intake, increase the expression of intestinal barrier-related genes, help maintain the intestinal microflora balance, and increase the abundance of beneficial bacteria in the intestine to improve intestinal immunity.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors wish to express their gratitude for the financial support from the Guangzhou Science and Technology Plan Project (No. 202206010035) and the Qingyuan Science and Technology Plan Project (No. 2022KJJH068).

Funding

This work was supported by the Guangzhou Science and Technology Plan Project (No. 202206010035) and the Qingyuan Science and Technology Plan Project (No. 2022KJJH068).

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Authors and Affiliations

  1. College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China

    Renkai Wang, Yanli Ren, Zhiqing Zhou & Weiyin Jiang

  2. College of Chemistry and Chemical Engineering, Zhongkai University of Agricultural Engineering, 24 East Sand Street, Guangzhou, 510225, China

    Hafiz Umer Javad & Xugang Shu

  3. Guangxi College and University Key Laboratory of High-Value Utilization of Seafood and Prepared Food in Beibu Gulf, College of Food Engineering, Beibu Gulf University, Qinzhou, China

    Hafiz Umer Javad

Authors
  1. Renkai Wang
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  2. Yanli Ren
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  3. Hafiz Umer Javad
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  4. Zhiqing Zhou
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  5. Weiyin Jiang
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  6. Xugang Shu
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Contributions

Conceptualization, funding acquisition, project administration, resources, and supervision were performed by XS.

Formal analysis and methodology were performed by RW and YR.

The first draft of the manuscript was written by RW and HUJ.

Visualization and writing—review and editing were performed by RW.

Investigation and data curation were performed by ZZ and WJ.

All the authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Xugang Shu.

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Ethics Approval

The experiments conducted for this study were carried out following the specifications established by the Chinese Ministry of Agriculture. The Animal Ethics Committee of Zhongkai University of Agriculture and Engineering approved (approval code: No. 20220722–2) geese experiments.

Competing Interests

The authors declare no competing interests.

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Wang, R., Ren, Y., Javad, H.U. et al. Dietary Dihydromyricetin Zinc Chelate Supplementation Improves the Intestinal Health of Magang Geese. Biol Trace Elem Res (2024). https://doi.org/10.1007/s12011-024-04065-z

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