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Effects of Shock Waves on Oxidative Stress, Antioxidant Enzyme and Element Levels in Kidney of Rats

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Abstract

The aim of this study was to investigate the effect of extracorporeal shock wave lithotripsy (ESWL) on kidney oxidative stress and trace element levels of adult rats. Twelve male Wistar albino rats were divided equally into two groups. First group was used as control. The right-side kidneys of animals in second group were treated with 2,000 18-kV shock waves under anesthesia. Localization of the right kidney was achieved following contrast medium injection through a tail vein under flouroscopy control. The animals were sacrificed 72 h after the ESWL treatment, and the kidneys were taken. Malondialdehyde level was higher in the ESWL group than in the control. Reduced glutathione levels, superoxide dismutase, and glutathione peroxidase activities were lower in the ESWL group than those of the control. Fe, Cu, Pb, Mn, Cd, and Ni levels were lower in the ESWL group than in the control, although Mg level was higher in the ESWL group than in the control. In conclusion, the result of the present study indicated that ESWL treatment produced oxidative stress in the kidney and caused impairments on the antioxidant and trace element levels in the kidneys of rats.

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Abbreviations

ESWL:

Extracorporeal shock wave lithotripsy

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Acknowledgments

We thank Dr. Sıdık Keskin for his help in statistical evaluation of our data.

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Authors and Affiliations

  1. Department of Urology, Faculty of Medicine, Yüzüncü Yıl University, 65100, Van, Turkey

    İlhan Gecit, Necip Pirinçci, Mustafa Güneş & Kadir Ceylan

  2. Department of Biophysics, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey

    Servet Kavak

  3. Department of Physiology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey

    Ismail Meral

  4. Department of Chemistry, Division of Biochemistry, Faculty of Science, Yuzuncu Yil University, Van, Turkey

    Halit Demir

  5. Department of Histology and Embryology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey

    Nureddin Cengiz

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  1. İlhan Gecit
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Correspondence to İlhan Gecit.

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Gecit, İ., Kavak, S., Meral, I. et al. Effects of Shock Waves on Oxidative Stress, Antioxidant Enzyme and Element Levels in Kidney of Rats. Biol Trace Elem Res 144, 1069–1076 (2011). https://doi.org/10.1007/s12011-011-9124-8

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  • DOI: https://doi.org/10.1007/s12011-011-9124-8

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