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TIPS: indications, Contraindications, and Evaluation

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Abstract

Purpose of Review

This review summarizes the current and emerging indications, contraindications, and evaluation for TIPS. In the last three decades of use, there have been substantial changes and progress in this field, including the use of controlled-expansion, covered stents, which has broadened the clinical uses of TIPS.

Recent Findings

Recent findings have rapidly expanded the indications for TIPS, including emerging uses in hepatorenal syndrome, hepatopulmonary syndrome and before abdominal surgery. The widespread use of controlled-expansion, covered stents has decreased rates of post-TIPS hepatic encephalopathy, opening TIPS to a larger patient population.

Summary

Overall, with newer stent technology and more research in this area, the clinical utility and potential of TIPS has rapidly expanded. Going forward, a renewed focus on randomized-control trials and long-term outcomes will be a crucial element to selecting appropriate TIPS recipients and recommending emerging indications for this procedure.

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References

  1. Mauro E, Gadano A. What’s new in portal hypertension? Liver Int. 2020;40(S1):122–7. https://doi.org/10.1111/liv.14366.

    Article  PubMed  Google Scholar 

  2. Rössle M, Richter GM, Nöldge G, Palmaz JC, Wenz W, Gerok W. New non-operative treatment for variceal haemorrhage. Lancet. 1989;2(8655):153. https://doi.org/10.1016/s0140-6736(89)90201-8.

    Article  PubMed  Google Scholar 

  3. Praktiknjo M, Abu-Omar J, Chang J, Thomas D, Jansen C, Kupczyk P, et al. Controlled underdilation using novel VIATORR® controlled expansion stents improves survival after transjugular intrahepatic portosystemic shunt implantation. JHEP Rep. 2021;3(3):100264. https://doi.org/10.1016/j.jhepr.2021.100264.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Trebicka J, Bastgen D, Byrtus J, Praktiknjo M, Terstiegen S, Meyer C, et al. Smaller-diameter covered Transjugular Intrahepatic Portosystemic Shunt Stents are Associated with increased survival. Clin Gastroenterol Hepatol. 2019;17(13):2793–9e1. https://doi.org/10.1016/j.cgh.2019.03.042.

    Article  PubMed  Google Scholar 

  5. Boyer TD, Haskal ZJ. The role of Transjugular Intrahepatic Portosystemic Shunt (Tips) in the management of Portal Hypertension: Update 2009. Hepatology. 2010;51(1).

  6. Boike JR, Thornburg BG, Asrani SK, Fallon MB, Fortune BE, Izzy MJ, et al. North american practice-based recommendations for Transjugular Intrahepatic Portosystemic Shunts in Portal Hypertension. Clin Gastroenterol Hepatol. 2022;20(8):1636–62e36. https://doi.org/10.1016/j.cgh.2021.07.018.

    Article  PubMed  Google Scholar 

  7. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018;69(2):406–60. https://doi.org/10.1016/j.jhep.2018.03.024.

    Article  Google Scholar 

  8. Tripathi D, Stanley AJ, Hayes PC, Travis S, Armstrong MJ, Tsochatzis EA, et al. Transjugular intrahepatic portosystemic stent-shunt in the management of portal hypertension. Gut. 2020;69(7):1173–92. https://doi.org/10.1136/gutjnl-2019-320221.

    Article  PubMed  Google Scholar 

  9. García-Pagán JC, Caca K, Bureau C, Laleman W, Appenrodt B, Luca A, et al. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med. 2010;362(25):2370–9. https://doi.org/10.1056/NEJMoa0910102.

    Article  PubMed  Google Scholar 

  10. Hernández-Gea V, Procopet B, Giráldez Á, Amitrano L, Villanueva C, Thabut D, et al. Preemptive‐TIPS improves outcome in high‐risk variceal bleeding: an observational study. Hepatology. 2019;69(1):282–93. https://doi.org/10.1002/hep.30182.

    Article  CAS  PubMed  Google Scholar 

  11. Nicoară-Farcău O, Han G, Rudler M, Angrisani D, Monescillo A, Torres F, et al. Effects of Early Placement of Transjugular Portosystemic shunts in patients with high-risk Acute Variceal bleeding: a Meta-analysis of individual Patient Data. Gastroenterology. 2021;160(1):193–205e10. https://doi.org/10.1053/j.gastro.2020.09.026.

    Article  CAS  PubMed  Google Scholar 

  12. Lv Y, Yang Z, Liu L, Li K, He C, Wang Z, et al. Early TIPS with covered stents versus standard treatment for acute variceal bleeding in patients with advanced cirrhosis: a randomised controlled trial. Lancet Gastroenterol Hepatol. 2019;4(8):587–98. https://doi.org/10.1016/s2468-1253(19)30090-1.

    Article  PubMed  Google Scholar 

  13. Khan F, Tripathi D. Role of early transjugular intrahepatic portosystemic stent-shunt in acute variceal bleeding: an update of the evidence and future directions. World J Gastroenterol. 2021;27(44):7612–24. https://doi.org/10.3748/wjg.v27.i44.7612.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. ••Lv Y, Wang Z, Li K, Wang Q, Bai W, Yuan X et al. Risk Stratification Based on Chronic Liver Failure Consortium Acute Decompensation Score in Patients With Child-Pugh B Cirrhosis and Acute Variceal Bleeding. Hepatology. 2021;73(4):1478-93. doi: 10.1002/hep.31478. There has been a large volume of previous work establishing the uitlity of early TIPS in CP-C patients, and limited utility in CP-A patients. However, CP-B had been less clear. In this work, Lv suggest the utility of using CLIF-C AD scoring to stratify CP-B patients who will benefit most from early TIPS

  15. Trebicka J, Gu W, Ibáñez-Samaniego L, Hernández-Gea V, Pitarch C, Garcia E, et al. Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS. J Hepatol. 2020;73(5):1082–91. https://doi.org/10.1016/j.jhep.2020.04.024.

    Article  PubMed  Google Scholar 

  16. Thabut D, Pauwels A, Carbonell N, Remy AJ, Nahon P, Causse X, et al. Cirrhotic patients with portal hypertension-related bleeding and an indication for early-TIPS: a large multicentre audit with real-life results. J Hepatol. 2017;68(1):73–81. https://doi.org/10.1016/j.jhep.2017.09.002.

    Article  PubMed  Google Scholar 

  17. Hayes PC, Mookerjee RP. Early TIPS for portal hypertensive related bleeding: is resource or education the reason for failure to show clear survival benefit? J Hepatol. 2018;68(1):8–9. https://doi.org/10.1016/j.jhep.2017.11.001.

    Article  Google Scholar 

  18. Henry Z, Patel K, Patton H, Saad W. AGA clinical practice update on management of bleeding gastric Varices: Expert Review. Clin Gastroenterol Hepatol. 2021;19(6):1098–107e1. https://doi.org/10.1016/j.cgh.2021.01.027.

    Article  PubMed  Google Scholar 

  19. Lo GH, Liang HL, Chen WC, Chen MH, Lai KH, Hsu PI, et al. A prospective, randomized controlled trial of transjugular intrahepatic portosystemic shunt versus cyanoacrylate injection in the prevention of gastric variceal rebleeding. Endoscopy. 2007;39(08):679–85. https://doi.org/10.1055/s-2007-966591.

    Article  PubMed  Google Scholar 

  20. Procaccini NJ, Al-Osaimi AMS, Northup P, Argo C, Caldwell SH. Endoscopic cyanoacrylate versus transjugular intrahepatic portosystemic shunt for gastric variceal bleeding: a single-center U.S. analysis. Gastrointest Endosc. 2009;70(5):881–7. https://doi.org/10.1016/j.gie.2009.03.1169.

    Article  PubMed  Google Scholar 

  21. Wang YB, Zhang JY, Gong JP, Zhang F, Zhao Y. Balloon-occluded retrograde transvenous obliteration versus transjugular intrahepatic portosystemic shunt for treatment of gastric varices due to portal hypertension: a meta-analysis. J Gastroenterol Hepatol (Australia). 2016;31(4):727–33. https://doi.org/10.1111/jgh.13248.

    Article  Google Scholar 

  22. Barange K, Péron J-M, Imani K, Otal P, Payen J-L, Rousseau H, et al. Transjugular intrahepatic portosystemic shunt in the treatment of refractory bleeding from ruptured gastric varices. Hepatology. 1999;30(5):1139–43. https://doi.org/10.1002/hep.510300523.

    Article  CAS  PubMed  Google Scholar 

  23. Rössle M, Ochs A, Gülberg V, Siegerstetter V, Holl J, Deibert P, et al. A comparison of paracentesis and transjugular intrahepatic portosystemic shunting in patients with ascites. N Engl J Med. 2000;342(23):1701–7. https://doi.org/10.1056/nejm200006083422303.

    Article  PubMed  Google Scholar 

  24. Salerno F, Merli M, Riggio O, Cazzaniga M, Valeriano V, Pozzi M, et al. Randomized controlled study of TIPS versus paracentesis plus albumin in cirrhosis with severe ascites. Hepatology. 2004;40(3):629–35. https://doi.org/10.1002/hep.20364.

    Article  CAS  PubMed  Google Scholar 

  25. Sanyal AJ, Genning C, Reddy KR, Wong F, Kowdley KV, Benner K, et al. The north american study for the treatment of Refractory Ascites. Gastroenterology. 2003;124(3):634–41. https://doi.org/10.1053/gast.2003.50088.

    Article  PubMed  Google Scholar 

  26. Bureau C, Thabut D, Oberti F, Dharancy S, Carbonell N, Bouvier A, et al. Transjugular Intrahepatic Portosystemic shunts with covered stents increase transplant-free survival of patients with cirrhosis and recurrent ascites. Gastroenterology. 2017;152(1):157–63. https://doi.org/10.1053/j.gastro.2016.09.016.

    Article  PubMed  Google Scholar 

  27. Kok B, Abraldes JG. Patient selection in Transjugular Intrahepatic Portosystemic Shunt (TIPS) for refractory Ascites and Associated Conditions. Curr Hepatol Rep. 2019;18(2):197–205. https://doi.org/10.1007/s11901-019-00470-4.

    Article  Google Scholar 

  28. Ditah IC, Al Bawardy BF, Saberi B, Ditah C, Kamath PS. Transjugular intrahepatic portosystemic stent shunt for medically refractory hepatic hydrothorax: a systematic review and cumulative meta-analysis. World J Hepatol. 2015;7(13):1797–806. https://doi.org/10.4254/wjh.v7.i13.1797.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Romero S, Lim AK, Singh G, Kodikara C, Shingaki-Wells R, Chen L, et al. Natural history and outcomes of patients with liver cirrhosis complicated by hepatic hydrothorax. World J Gastroenterol. 2022;28(35):5175–87. https://doi.org/10.3748/wjg.v28.i35.5175.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Biggins SW, Angeli P, Garcia-Tsao G, Ginès P, Ling SC, Nadim MK et al. Diagnosis, evaluation, and management of Ascites, spontaneous bacterial peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the study of Liver Diseases. Hepatology. 2021;74(2).

  31. Rössle M, Gerbes AL. TIPS for the treatment of refractory ascites, hepatorenal syndrome and hepatic hydrothorax: a critical update. Gut. 2010;59(7):988–1000. https://doi.org/10.1136/gut.2009.193227.

    Article  PubMed  Google Scholar 

  32. Krishnamoorthy TL, Taneja M, Chang PE. Symptomatic hepatic hydrothorax successfully treated with transjugular intrahepatic portosystemic shunt (TIPS)-role of titration of portosystemic gradient reduction to avoid post-TIPS encephalopathy. Clin Case Rep. 2014;2(3):93–7. https://doi.org/10.1002/ccr3.70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Dhanasekaran R, West JK, Gonzales PC, Subramanian R, Parekh S, Spivey JR, et al. Transjugular intrahepatic portosystemic shunt for symptomatic refractory hepatic hydrothorax in patients with cirrhosis. Am J Gastroenterol. 2010;105(3):635–41. https://doi.org/10.1038/ajg.2009.634.

    Article  PubMed  Google Scholar 

  34. Campos S, Gomes D, Sofia C. Transjugular intrahepatic portosystemic shunt in refractory hydrothorax - a contribution to an unexplored indication. Eur J Gastroenterol Hepatol. 2016;28(6):661–6. https://doi.org/10.1097/meg.0000000000000623.

    Article  PubMed  Google Scholar 

  35. Young S, Bermudez J, Zhang L, Rostambeigi N, Golzarian J. Transjugular intrahepatic portosystemic shunt (TIPS) placement: a comparison of outcomes between patients with hepatic hydrothorax and patients with refractory ascites. Diagn Interv Imaging. 2019;100(5):303–8. https://doi.org/10.1016/j.diii.2018.10.006.

    Article  CAS  PubMed  Google Scholar 

  36. Gou X, Jia W, He C, Yuan X, Niu J, Xu J, et al. Hepatic hydrothorax does not increase the risk of death after transjugular intrahepatic portosystemic shunt in cirrhosis patients. Eur Radiol. 2023;33(5):3407–15. https://doi.org/10.1007/s00330-022-09357-3.

    Article  PubMed  Google Scholar 

  37. Rodríguez-Roisin R, Krowka MJ. Hepatopulmonary syndrome–a liver-induced lung vascular disorder. N Engl J Med. 2008;358(22):2378–87. https://doi.org/10.1056/NEJMra0707185.

    Article  PubMed  Google Scholar 

  38. Allgaier HP, Haag K, Ochs A, Hauenstein KH, Jeserich M, Krause T, et al. Hepato-pulmonary syndrome: successful treatment by transjugular intrahepatic portosystemic stent-shunt (TIPS). J Hepatol. 1995;23(1):102. https://doi.org/10.1016/0168-8278(95)80318-1.

    Article  CAS  PubMed  Google Scholar 

  39. Riegler JL, Lang KA, Johnson SP, Westerman JH. Transjugular intrahepatic portosystemic shunt improves oxygenation in hepatopulmonary syndrome. Gastroenterology. 1995;109(3):978–83. https://doi.org/10.1016/0016-5085(95)90409-3.

    Article  CAS  PubMed  Google Scholar 

  40. Chevallier P, Novelli L, Motamedi J-P, Hastier P, Brunner P, Bruneton J-N. Hepatopulmonary syndrome successfully treated with transjugular intrahepatic portosystemic shunt: a three-year follow-up. J vascular interventional radiology: JVIR. 2004;15(6):647–8. https://doi.org/10.1097/01.rvi.0000127885.68272.e9.

    Article  Google Scholar 

  41. Tsauo J, Zhao H, Zhang X, Ma H, Jiang M, Weng N, et al. Effect of Transjugular Intrahepatic Portosystemic Shunt Creation on Pulmonary Gas Exchange in patients with Hepatopulmonary Syndrome: a prospective study. J Vasc Interv Radiol. 2019;30(2):170–7. https://doi.org/10.1016/j.jvir.2018.09.017.

    Article  PubMed  Google Scholar 

  42. Lasch HM, Fried MW, Zacks SL, Odell P, Johnson MW, Gerber DA, et al. Use of transjugular intrahepatic portosystemic shunt as a bridge to liver transplantation in a patient with severe hepatopulmonary syndrome. Liver Transpl. 2001;7(2):147–9. https://doi.org/10.1053/jlts.2001.21287.

    Article  CAS  PubMed  Google Scholar 

  43. Benítez C, Arrese M, Jorquera J, Godoy I, Conteras A, Loyola S, et al. Successful treatment of severe hepatopulmonary syndrome with a sequential use of TIPS placement and liver transplantation. Ann Hepatol. 2009;8(1):71–4. https://doi.org/10.1016/S1665-2681(19)31816-2.

    Article  PubMed  Google Scholar 

  44. Simonetto DA, Gines P, Kamath PS. Hepatorenal syndrome: pathophysiology, diagnosis, and management. BMJ. 2020;370:m2687. https://doi.org/10.1136/bmj.m2687.

    Article  PubMed  Google Scholar 

  45. Guevara M, Ginès P, Bandi JC, Gilabert R, Sort P, Jiménez W, et al. Transjugular intrahepatic portosystemic shunt in hepatorenal syndrome: effects on renal function and vasoactive systems. Hepatology. 1998;28(2):416–22. https://doi.org/10.1002/hep.510280219.

    Article  CAS  PubMed  Google Scholar 

  46. Wong F, Pantea L, Sniderman K. Midodrine, octreotide, albumin, and TIPS in selected patients with cirrhosis and type 1 hepatorenal syndrome. Hepatology. 2004;40(1):55–64. https://doi.org/10.1002/hep.20262.

    Article  CAS  PubMed  Google Scholar 

  47. Brensing KA, Textor J, Perz J, Schiedermaier P, Raab P, Strunk H, et al. Long term outcome after transjugular intrahepatic portosystemic stent-shunt in non-transplant cirrhotics with hepatorenal syndrome: a phase II study. Gut. 2000;47(2):288–95. https://doi.org/10.1136/gut.47.2.288.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Ripoll C, Platzer S, Franken P, Aschenbach R, Wienke A, Schuhmacher U, et al. Liver-HERO: hepatorenal syndrome-acute kidney injury (HRS-AKI) treatment with transjugular intrahepatic portosystemic shunt in patients with cirrhosis-a randomized controlled trial. Trials. 2023;24(1):258. https://doi.org/10.1186/s13063-023-07261-9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Inchingolo R, Posa A, Mariappan M, Tibana TK, Nunes TF, Spiliopoulos S, et al. Transjugular intrahepatic portosystemic shunt for Budd-Chiari syndrome: a comprehensive review. World J Gastroenterol. 2020;26(34):5060–73. https://doi.org/10.3748/wjg.v26.i34.5060.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Garcia-Pagán JC, Heydtmann M, Raffa S, Plessier A, Murad S, Fabris F, et al. TIPS for Budd-Chiari syndrome: long-term results and prognostics factors in 124 patients. Gastroenterology. 2008;135(3):808–15. https://doi.org/10.1053/j.gastro.2008.05.051.

    Article  PubMed  Google Scholar 

  51. Sonavane AD, Amarapurkar DN, Rathod KR, Punamiya SJ. Long Term Survival of Patients undergoing TIPS in Budd-Chiari Syndrome. J Clin Exp Hepatol. 2019;9(1):56–61. https://doi.org/10.1016/j.jceh.2018.02.008.

    Article  PubMed  Google Scholar 

  52. Wongjarupong N, Young S, Huynh RK, Lake J, Lim N. Long-term improvement in liver function following Transjugular Intrahepatic Portosystemic Shunt in patients with Budd-Chiari Syndrome. J Clin Exp Hepatol. 2022;12(6):1474–9. https://doi.org/10.1016/j.jceh.2022.07.251.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Ziser A, Plevak David J, Wiesner Russell H, Rakela J, Offord Kenneth P. Brown David L. Morbidity and Mortality in Cirrhotic Patients undergoing anesthesia and surgery anesthesiology. 1999;90(1):42–53. doi: https://doi.org/10.1097/00000542-199901000-00008.

  54. Chang J, Höfer P, Böhling N, Lingohr P, Manekeller S, Kalff JC, et al. Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score. JHEP Rep. 2022;4(3):100442. https://doi.org/10.1016/j.jhepr.2022.100442. This work explore the hypothesis that TIPS before abdominal surgery might reduce the risk of ACLF, a known complication of abdominal surgery in cirrhotic patients. Chang et al establish a CLIF-AD score>45 as a useful cuttoff for determining who might benefit most from TIPS before a viseral operation to reduce changes of post-operative ACLF.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Aryan M, McPhail J, Ravi S, Harris P, Allamneni C, Shoreibah M. Perioperative Transjugular Intrahepatic Portosystemic Shunt is Associated with decreased postoperative complications in decompensated cirrhotics undergoing abdominal surgery. Am Surg. 2022;88(7):1613–20. https://doi.org/10.1177/00031348211069784. In this retrospective obervational study, Aryan et al expand the potential benefits of pre-operative TIPS to include lower rates of post-operative ascites, AKI and infection comparted to patients who did not receive pre-operative TIPS.

    Article  PubMed  Google Scholar 

  56. Manzano-Nunez R, Jimenez-Masip A, Chica-Yanten J, Ibn-Abdelouahab A, Sartelli M, de’Angelis N, et al. Unlocking the potential of TIPS placement as a bridge to elective and emergency surgery in cirrhotic patients: a meta-analysis and future directions for endovascular resuscitation in acute care surgery. World J Emerg Surg. 2023;18(1):30. https://doi.org/10.1186/s13017-023-00498-4.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Gaba RC, Parvinian A. How quickly does ascites respond to TIPS? Clinical follow-up of a cohort of eighty patients. Diagn Interv Radiol. 2014;20(4):364. https://doi.org/10.5152/dir.2014.13479.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Busk TM, Bendtsen F, Poulsen JH, Clemmesen JO, Larsen FS, Goetze JP, et al. Transjugular intrahepatic portosystemic shunt: impact on systemic hemodynamics and renal and cardiac function in patients with cirrhosis. Am J Physiol Gastrointest Liver Physiol. 2018;314(2):G275–g86. https://doi.org/10.1152/ajpgi.00094.2017.

    Article  CAS  PubMed  Google Scholar 

  59. Wannhoff A, Hippchen T, Weiss CS, Friedrich K, Rupp C, Neumann-Haefelin C, et al. Cardiac volume overload and pulmonary hypertension in long-term follow-up of patients with a transjugular intrahepatic portosystemic shunt. Aliment Pharmacol Ther. 2016;43(9):955–65. https://doi.org/10.1111/apt.13569.

    Article  CAS  PubMed  Google Scholar 

  60. Rabie RN, Cazzaniga M, Salerno F, Wong F. The use of E/A ratio as a predictor of outcome in cirrhotic patients treated with transjugular intrahepatic portosystemic shunt. Am J Gastroenterol. 2009;104(10):2458–66. https://doi.org/10.1038/ajg.2009.321.

    Article  PubMed  Google Scholar 

  61. Cazzaniga M, Salerno F, Pagnozzi G, Dionigi E, Visentin S, Cirello I, et al. Diastolic dysfunction is associated with poor survival in patients with cirrhosis with transjugular intrahepatic portosystemic shunt. Gut. 2007;56(6):869–75. https://doi.org/10.1136/gut.2006.102467.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Jansen C, Schröder A, Schueler R, Lehmann J, Praktiknjo M, Uschner FE, et al. Left ventricular longitudinal Contractility predicts Acute-on-chronic liver failure development and Mortality after Transjugular Intrahepatic Portosystemic Shunt. Hepatol Commun. 2019;3(3):340–7. https://doi.org/10.1002/hep4.1308.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Mizrahi M, Adar T, Shouval D, Bloom AI, Shibolet O. Endotipsitis-persistent infection of transjugular intrahepatic portosystemic shunt: pathogenesis, clinical features and management. Liver Int. 2010;30(2):175–83. https://doi.org/10.1111/j.1478-3231.2009.02158.x.

    Article  PubMed  Google Scholar 

  64. Niyas VKM, Keri VC, Kumar P. Endotipsitis: an underdiagnosed complication of Transjugular Intrahepatic Portosystemic shunts. J Clin Exp Hepatol. 2022;12(1):222–4. https://doi.org/10.1016/j.jceh.2021.02.009.

    Article  CAS  PubMed  Google Scholar 

  65. Armstrong PK, MacLeod C. Infection of transjugular intrahepatic portosystemic shunt devices: three cases and a review of the literature. Clin Infect Dis. 2003;36(4):407–12. https://doi.org/10.1086/346156.

    Article  PubMed  Google Scholar 

  66. Suhocki PV, Lungren MP, Kapoor B, Kim CY. Transjugular intrahepatic portosystemic shunt complications: prevention and management. Semin Intervent Radiol. 2015;32(2):123–32. https://doi.org/10.1055/s-0035-1549376.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Yang C, Zhu X, Liu J, Shi Q, Du H, Chen Y, et al. Development and Validation of Prognostic Models to Estimate the risk of overt hepatic Encephalopathy after TIPS Creation: a Multicenter Study. Clin Transl Gastroenterol. 2022;13(3):e00461. https://doi.org/10.14309/ctg.0000000000000461.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Nardelli S, Gioia S, Pasquale C, Pentassuglio I, Farcomeni A, Merli M, et al. Cognitive impairment predicts the occurrence of hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt. Official J Am Coll Gastroenterol | ACG. 2016;111(4):523–8. https://doi.org/10.1038/ajg.2016.29.

    Article  Google Scholar 

  69. •• Saab S, Zhao M, Asokan I, Yum JJ, Lee EW. History of Hepatic Encephalopathy Is Not a Contraindication to Transjugular Intrahepatic Portosystemic Shunt Placement for Refractory Ascites. Clin Transl Gastroenterol. 2021;12(8):e00378. doi: 10.14309/ctg.0000000000000378. Refractory ascites is one of the most common indications for TIPS and HE is one of the most common compolications of the procedure. Given that many patients with PH have a history of HE, Saab suggest with this work that HE should not be a contraindication for TIPS as long as the HE is well controlled before TIPS procedure.

  70. Wang Q, Lv Y, Bai M, Wang Z, Liu H, He C, et al. Eight millimetre covered TIPS does not compromise shunt function but reduces hepatic encephalopathy in preventing variceal rebleeding. J Hepatol. 2017;67(3):508–16. https://doi.org/10.1016/j.jhep.2017.05.006.

    Article  PubMed  Google Scholar 

  71. • Lv Y, Chen H, Luo B, Bai W, Li K, Wang Z et al. Concurrent large spontaneous portosystemic shunt embolization for the prevention of overt hepatic encephalopathy after TIPS: A randomized controlled trial. Hepatology. 2022;76(3):676 – 88. doi: 10.1002/hep.32453. Lv present the first RCT demonstrating the efficacy of concurrent SPSS embolization with TIPS to reduce post-TIPS rates of HE by 62%. This suggests the utility of considering prophylactic large SPSS embolization for specific patients to reduce rates of post-TIPS HE

  72. ••Knight GM, Clark J, Boike JR, Maddur H, Ganger DR, Talwar A, et al. 10.1002/hep.31915. Extra hepatic portal vein occlusion from portal vein thrombosis is a disease process with limited treatment options. Here, for the first time, TIPS has been shown as a feasible option for treatment of EHPVO in patients who failed first-line treatments. Hepatology. 2021;74(5):2735–44. TIPS for Adults Without Cirrhosis With Chronic Mesenteric Venous Thrombosis and EHPVO Refractory to Standard-of-Care Therapy.

  73. Thornburg B, Desai K, Hickey R, Hohlastos E, Kulik L, Ganger D, et al. Pretransplantation Portal Vein Recanalization and Transjugular Intrahepatic Portosystemic Shunt Creation for chronic portal vein thrombosis: final analysis of a 61-Patient cohort. J Vasc Interv Radiol. 2017;28(12):1714–21e2. https://doi.org/10.1016/j.jvir.2017.08.005.

    Article  PubMed  Google Scholar 

  74. Salerno F, Merli M, Cazzaniga M, Valeriano V, Rossi P, Lovaria A, et al. MELD score is better than child-pugh score in predicting 3-month survival of patients undergoing transjugular intrahepatic portosystemic shunt. J Hepatol. 2002;36(4):494–500. https://doi.org/10.1016/s0168-8278(01)00309-9.

    Article  PubMed  Google Scholar 

  75. Krishnan A, Woreta TA, Vaidya D, Liu Y, Hamilton JP, Hong K, et al. MELD or MELD-Na as a predictive model for Mortality following Transjugular Intrahepatic Portosystemic Shunt Placement. J Clin Transl Hepatol. 2023;11(1):38–44. https://doi.org/10.14218/jcth.2021.00513.

    Article  PubMed  Google Scholar 

  76. Montgomery A, Ferral H, Vasan R, Postoak DW. MELD score as a predictor of early death in patients undergoing Elective Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedures. Cardiovasc Interv Radiol. 2005;28(3):307–12. https://doi.org/10.1007/s00270-004-0145-y.

    Article  Google Scholar 

  77. Rashidi-Alavijeh J, Kahraman A, Gerken G, Theysohn JM, Willuweit K, Hoyer DP, et al. Enzymatic liver function measured by LiMAx is superior to current standard methods in predicting transplant-free survival after TIPS implantation. Sci Rep. 2021;11(1):13834. https://doi.org/10.1038/s41598-021-93392-5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Cholankeril G, Li AA, Dennis BB, Gadiparthi C, Kim D, Toll AE, et al. Pre-Operative Delta-MELD is an independent predictor of higher mortality following liver transplantation. Sci Rep. 2019;9(1):8312. https://doi.org/10.1038/s41598-019-44814-y.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Menegaux F, Baker E, Keeffe EB, Monge H, Egawa H, Esquivel CO. Impact of transjugular intrahepatic portosystemic shunt on orthotopic liver transplantation. World J Surg. 1994;18(6):866–70. https://doi.org/10.1007/bf00299089. discussion 70 – 1.

    Article  CAS  PubMed  Google Scholar 

  80. Addeo P, Schaaf C, Faitot F, Terrone A, Julliard O, Besch C, et al. Misplacement of transjugular intrahepatic portosystemic shunts: a surgical challenge for liver transplantation? Surgery. 2021;169(2):447–54. https://doi.org/10.1016/j.surg.2020.07.028.

    Article  PubMed  Google Scholar 

  81. Hinojosa-Gonzalez DE, Tellez-Garcia E, Salgado-Garza G, Roblesgil-Medrano A, Bueno-Gutierrez LC, Villegas-De Leon SU, et al. Intraoperative and postoperative impact of pretransplantation transjugular intrahepatic portosystemic shunts in orthotopic liver transplantations: a systematic review and meta-analysis. Turk J Surg. 2022;38(2):121–33. https://doi.org/10.47717/turkjsurg.2022.5702.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Unger LW, Stork T, Bucsics T, Rasoul-Rockenschaub S, Staufer K, Trauner M, et al. The role of TIPS in the management of liver transplant candidates. United Eur Gastroenterol J. 2017;5(8):1100–7. https://doi.org/10.1177/2050640617704807.

    Article  Google Scholar 

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A.C. and J.B wrote the main manuscript text and prepared Tables 1 and 2.

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Correspondence to Justin R. Boike.

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Dr. Boike has received investigator-initiated grant funding and consulting fees from W. L. Gore and Associates, the manufacturer of TIPS endoprosthesis. W. L. Gore and Associates had no influence on the authoring of this article.

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Carroll, A., Boike, J.R. TIPS: indications, Contraindications, and Evaluation. Curr Gastroenterol Rep 25, 232–241 (2023). https://doi.org/10.1007/s11894-023-00884-7

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