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Microstructure, Corrosion, and Biological Responses of Mg-Al-Zn-Sr-xCa Alloys for Bioresorbable Applications

  • Influence of Processing on Microstructure and Properties of Mg Alloys
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Abstract

Mg-Al-Zn-Sr-Ca alloys with varying calcium content were prepared and examined for biomedical applications. Microstructural observations indicated grain refinement and increased second phase precipitation with increasing Ca content. Immersion test, potentiodynamic polarization study, and impedance spectroscopy revealed that Ca content up to 1 wt.% improved the corrosion response of Mg-Al-Zn-Sr-Ca alloys studied in this work. Due to the combined effect of grain refinement, second phase precipitate barrier, and protective layer formation, the corrosion rate dropped from 1.84 mm/year in alloy Ca0.2 to 1.01 mm/year in alloy Ca1.0. Biocompatibility was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Ca1.0 showed the highest cell attachment and proliferation density. Ca formed Mg2Ca and improved the cell viability of the alloys.

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References

  1. K.M.R. Nuss and B. von Rechenberg, Open Orthop. J. 2, 66 (2008).

    Google Scholar 

  2. R.W. Westerman and B.E. Scammell, Surg. 30, 54 (2012).

    Google Scholar 

  3. M.D. Markel, Equine Fract. Repair (Wiley, New Jersey, 2019).

    Google Scholar 

  4. A.G. Dias, M.A. Lopes, I.R. Gibson, and J.D. Santos, J. Non. Cryst. Solids 330, 81 (2003).

    Google Scholar 

  5. H. Chai, L. Guo, X. Wang, Y. Fu, J. Guan, L. Tan, L. Ren, and K. Yang, J. Mater. Sci. Mater. Med. 22, 2525 (2011).

    Google Scholar 

  6. D. Ceroni, C. Grumetz, O. Desvachez, S. Pusateri, P. Dunand, and E. Samara, J. Child. Orthop. 10, 605 (2016).

    Google Scholar 

  7. M. Peron, J. Torgersen, and F. Berto, Metals (Basel). 7, (2017).

  8. M. Haseeb, M.F. Butt, T. Altaf, K. Muzaffar, A. Gupta, and A. Jallu, Int. J. Health Sci. (Qassim). 11, 1 (2017).

    Google Scholar 

  9. M.G. Seelig, Arch. Surg. 8, 669 (1924).

    Google Scholar 

  10. R. Zeng, W. Dietzel, F. Witte, N. Hort, and C. Blawert, Adv. Eng. Mater. 10, B3 (2008).

    Google Scholar 

  11. W. Xu, N. Birbilis, G. Sha, Y. Wang, J.E. Daniels, Y. **ao, and M. Ferry, Nat. Mater. 14, 1229 (2015).

    Google Scholar 

  12. X. Gu, Y. Zheng, Y. Cheng, S. Zhong, and T. **, Biomaterials 30, 484 (2009).

    Google Scholar 

  13. H.M. Wong, P. Chu, K. Cheung, K. Luk, and K. Yeung, Orthop. Proc. 96-B, 92 (2014).

    Google Scholar 

  14. M. Salahshoor and Y. Guo, Mater. (Basel, Switzerland) 5, 135 (2012).

    Google Scholar 

  15. V.S. Telang, R. Pemmada, V. Thomas, S. Ramakrishna, P. Tandon, and H.S. Nanda, Curr. Opin. Biomed. Eng. 17, 100264 (2021).

    Google Scholar 

  16. T. Zhu, Y. Yu, J. Yang, Y. Shen, L. He, and Y. **ong, Mater. Chem. Phys. 259, 124039 (2021).

    Google Scholar 

  17. S. Fajardo, J. Bosch, and G.S. Frankel, Corros. Sci. 146, 163 (2019).

    Google Scholar 

  18. G. Song and D. StJohn, Int. J. Cast Met. Res. 12, 327 (2000).

    Google Scholar 

  19. R.-C. Zeng, W.-C. Qi, F. Zhang, and S.-Q. Li, Regen. Biomater. 3, 49 (2016).

    Google Scholar 

  20. M. Razavi, M. Fathi, O. Savabi, D. Vashaee, and L. Tayebi, J. Biomed. Mater. Res. Part A 103, 1798 (2015).

    Google Scholar 

  21. N. Yang, F. Gong, B. Liu, Y. Hao, Y. Chao, H. Lei, X. Yang, Y. Gong, X. Wang, Z. Liu, and L. Cheng, Nat. Commun. 13, 2336 (2022).

    Google Scholar 

  22. K. Kubota, M. Mabuchi, and K. Higashi, J. Mater. Sci. 34, 2255 (1999).

    Google Scholar 

  23. A. Deschamps, F. Livet, and Y. Bréchet, Acta Mater. 47, 281 (1998).

    Google Scholar 

  24. M.L.M.N.S. Gupta, Magnesium, Magnesium Alloys, and Magnesium Composites (Wiley, New Jersey, 2011).

    Google Scholar 

  25. C.C. Willhite, N.A. Karyakina, R.A. Yokel, N. Yenugadhati, T.M. Wisniewski, I.M.F. Arnold, F. Momoli, and D. Krewski, Crit. Rev. Toxicol. 44(Suppl 4), 1 (2014).

    Google Scholar 

  26. K. Klotz, W. Weistenhöfer, F. Neff, A. Hartwig, C. van Thriel, and H. Drexler, Dtsch. Arztebl. Int. 114, 653 (2017).

    Google Scholar 

  27. H.S. Brar, J. Wong, and M.V. Manuel, J. Mech. Behav. Biomed. Mater. 7, 87 (2012).

    Google Scholar 

  28. D.M. Jiang, Z.Y. Cao, X. Sun, L. Guo, and J.G. Liu, Mater. Res. Innov. 17, 33 (2013).

    Google Scholar 

  29. E. Zhang, D. Yin, L. Xu, L. Yang, and K. Yang, Mater. Sci. Eng. C 29, 987 (2009).

    Google Scholar 

  30. D. Vojtěch, J. Kubásek, J. Šerák, and P. Novák, Acta Biomater. 7, 3515 (2011).

    Google Scholar 

  31. M. Nagata and B. Lönnerdal, J. Nutr. Biochem. 22, 172 (2011).

    Google Scholar 

  32. M.M. Almoudi, A.S. Hussein, M.I. Abu Hassan, and N. Mohamad Zain, Saudi. Dent. J. 30, 283 (2018).

    Google Scholar 

  33. Y.C. Lee, A.K. Dahle, and D.H. StJohn, Metall. Mater. Trans. A 31, 2895 (2000).

    Google Scholar 

  34. H. Pan, K. Pang, F. Cui, F. Ge, C. Man, X. Wang, and Z. Cui, Corros. Sci. 157, 420 (2019).

    Google Scholar 

  35. T. Mandal, S. Dasgupta, A. Barui, and S. Kundu, Mater. Sci. Technol. 38, 1134 (2022).

    Google Scholar 

  36. R.V. Suganthi, K. Elayaraja, M.I.A. Joshy, V.S. Chandra, E.K. Girija, and S.N. Kalkura, Mater. Sci. Eng. C 31, 593 (2011).

    Google Scholar 

  37. M. Bornapour, N. Muja, D. Shum-Tim, M. Cerruti, and M. Pekguleryuz, Acta Biomater. 9, 5319 (2013).

    Google Scholar 

  38. X. Zeng, Y. Wang, W. Ding, A.A. Luo, and A.K. Sachdev, Metall. Mater. Trans. A 37, 1333 (2006).

    Google Scholar 

  39. Y. Fan, G.H. Wu, and C.Q. Zhai, Mater. Sci. Forum. 546–549, 567 (2007).

  40. A.A. Gorustovich, T. Steimetz, R.L. Cabrini, and J.M. Porto López, J. Biomed. Mater. Res. Part A 92, 232 (2010).

    Google Scholar 

  41. Q. Huang, L. Liu, H. Wu, K. Li, N. Li, and Y. Liu, Mater. Sci. Eng. C 106, 110158 (2020).

    Google Scholar 

  42. P. Yin, N.F. Li, T. Lei, L. Liu, and C. Ouyang, J. Mater. Sci. Mater. Med. 24, 1365 (2013).

    Google Scholar 

  43. S.E. Harandi, M. Mirshahi, S. Koleini, M.H. Idris, H. Jafari, and M.R.A. Kadir, Mater. Res. 16, 11 (2013).

    Google Scholar 

  44. K. Hirai, H. Somekawa, Y. Takigawa, and K. Higashi, Mater. Sci. Eng. A 403, 276 (2005).

    Google Scholar 

  45. N. Erdmann, N. Angrisani, J. Reifenrath, A. Lucas, F. Thorey, D. Bormann, and A. Meyer-Lindenberg, Acta Biomater. 7, 1421 (2011).

    Google Scholar 

  46. Z. Li, X. Gu, S. Lou, and Y. Zheng, Biomaterials 29, 1329 (2008).

    Google Scholar 

  47. S.-S. Li, B. Tang, and D.-B. Zeng, J. Alloys Compd. 437, 317 (2007).

    Google Scholar 

  48. N.T. Kirkland, N. Birbilis, J. Walker, T. Woodfield, G.J. Dias, and M.P. Staiger, J. Biomed. Mater. Res. B. Appl. Biomater. 95, 91 (2010).

    Google Scholar 

  49. B. Zberg, P.J. Uggowitzer, and J.F. Löffler, Nat. Mater. 8, 887 (2009).

    Google Scholar 

  50. X. Zhao, L. Shi, and J. Xu, J. Mech. Behav. Biomed. Mater. 18, 181 (2013).

    Google Scholar 

  51. H.R.B. Rad, M.H. Idris, M.R.A. Kadir, and S. Farahany, Mater. Des. 33, 88 (2012).

    Google Scholar 

  52. Q. Peng, X. Li, N. Ma, R. Liu, and H. Zhang, J. Mech. Behav. Biomed. Mater. 10, 128 (2012).

    Google Scholar 

  53. M. Aljarrah, M. Medraj, X. Wang, E. Essadiqi, A. Muntasar, and G. Dénès, J. Alloys Compd. 436, 131 (2007).

    Google Scholar 

  54. M. Klinger, J. Appl. Crystallogr. 50, 1226 (2017).

    Google Scholar 

  55. Y. Zheng, Magnesium Alloys as Degradable Biomaterials, vol 328 (CRC Press, Boca Raton, 2016).

    Google Scholar 

  56. S. Izumi, M. Yamasaki, and Y. Kawamura, Corros. Sci. 51, 395 (2009).

    Google Scholar 

  57. G.L. Song and A. Atrens, Adv. Eng. Mater. 1, 11 (1999).

    Google Scholar 

  58. M. Mandal, A.P. Moon, G. Deo, C.L. Mendis, and K. Mondal, Corros. Sci. 78, 172 (2014).

    Google Scholar 

  59. B.-S. You, W.-W. Park, and I.-S. Chung, Scr. Mater. 42, 1089. (2000).

    Google Scholar 

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Authors and Affiliations

  1. Metallurgy and Materials Engineering, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, West Bengal, 711103, India

    Tapendu Mandal & Sukumar Kundu

  2. Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, West Bengal, 711103, India

    Shalini Dasgupta & Ananya Barui

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  1. Tapendu Mandal
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Mandal, T., Dasgupta, S., Barui, A. et al. Microstructure, Corrosion, and Biological Responses of Mg-Al-Zn-Sr-xCa Alloys for Bioresorbable Applications. JOM 75, 2299–2313 (2023). https://doi.org/10.1007/s11837-022-05595-4

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