Abstract
Cases of acute pancreatitis induced by organophosphate intoxication are encountered occasionally in clinics, but very few of them develop into severe pancreas necrosis and irreversible pancreatic function impairment. Here, we report a 47-year-old female organophosphate poisoning case after ingestion of massive insecticides; she was considered to have total necrosis and function failure of the pancreas via serum amylase test, glucose level test, and CT imaging. The patient exhibited no relief under the regular medicine treatment, which included sandostatin, antibiotics, intravenous atropine, and pralidoxime methiodide. She received percutaneous catheterization and drainage of pancreatic zone to expel hazardous necrotic waste, also by which the pathogenic evidence was obtained and the antibiotics were adjusted subsequently. The patient recovered gradually, was discharged after 2 weeks, and was prescribed with oral pancreatin capsules before meals and hypodermic insulin at meals and bedtime to compensate the impaired pancreatic function.
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Yoshida S, Okada H, Nakano S, Shirai K, Yuhara T, Kojima H, Doi T, Kato H, Suzuki K, Morishita K, Murakami E, Ushikoshi H, Toyoda I, Ogura S. Much caution does no harm! Organophosphate poisoning often causes pancreatitis. J Intensive Care 2015; 3(1): 21–25
Goud M, Nayal B, Deepa K, Devi OS, Devaki RN, Anitha M. A case of acute pancreatitis with occupational exposure to organophosphorus compound. Toxicol Int 2012; 19(2): 223–224
Panieri E, Krige JE, Bornman PC, Linton DM. Severe necrotizing pancreatitis caused by organophosphate poisoning. J Clin Gastroenterol 1997; 25(2): 463–465
Roeyen G, Chapelle T, Jorens P, de Beeck BO, Ysebaert D. Necrotizing pancreatitis due to poisoning with organophosphate pesticides. Acta Gastroenterol Belg 2008; 71(1): 27–29
Venugopal L, Dharma Rao V, Srinivas Rao M, Mallikarjuna Y. Toxic pancreatitis with an intra-abdominal abscess which was caused by organophosphate poisoning (OP). J Clin Diagn Res 2013; 7(2): 366–368
Hamaguchi M, Namera A, Tsuda N, Uejima T, Maruyama K, Kanai T, Sakata I. Severe acute pancreatitis caused by organophosphate poisoning. Chudoku Kenkyu 2006; 19(4): 395–399
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We thank Dr. **gya Zhou from the Department of Medical Records for her kind support in the retrieval of documents.
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Hou, R., Zhang, H., Chen, H. et al. Total pancreatic necrosis after organophosphate intoxication. Front. Med. 13, 285–288 (2019). https://doi.org/10.1007/s11684-018-0626-z
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DOI: https://doi.org/10.1007/s11684-018-0626-z