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Disrupted default mode network connectivity in male adolescents with conduct disorder

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Abstract

Conduct disorder (CD) is a serious behavioral disorder of childhood and adolescence. The default mode network (DMN) is a brain network which supports self-referential cognitive processes and is typically deactivated during task performance. The aim of this study was to investigate DMN connectivity in male adolescents with pure CD compared to typically-develo** controls. Eighteen male adolescents with CD and 18 sex-, age- and education-matched typically-develo** (TD) participants were recruited. Current and lifetime psychiatric disorders were assessed using the Chinese version of the Schedule for Affective Disorder and Schizophrenia for School-Age Children-Present and Lifetime Version. Resting state functional magnetic resonance imaging (fMRI) data were obtained using a 3.0 T scanner. Independent components analysis (ICA) was used to investigate functional connectivity between the DMN and related brain regions. DMN activity was observed in medial prefrontal, posterior cingulate, and lateral parietal cortices, and extended to the brainstem. Adolescents with CD showed significantly reduced functional connectivity within the bilateral posterior cingulate cortex (PCC), bilateral precuneus and right superior temporal gyrus relative to TD controls. CD is associated with reduced functional connectivity within the DMN and between the DMN and other regions. These preliminary results suggest that deficits in DMN functional connectivity may serve as a biomarker of CD.

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Acknowledgments

This work was supported by MOE (Ministry of Education in China) Project of Humanities and Social Sciences (Project No. 13YJC190033), and the National Natural Science Foundation of China (NSFC, 81571341, 81371500, 81301155).

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Author notes

    Authors and Affiliations

    1. Mental Health Institute of The Second ** Wang

    2. Department of Psychiatry, Yale University & Olin Neuropsychiatric Research Center, Institute of Living, Whitehall Research, Building 200, Retreat Ave, Hartford, CT, 06106, USA

      Nailin Yao

    3. Academic Unit of Psychology, University of Southampton, Southampton, UK

      Graeme Fairchild

    4. Department of Health Management Center, The Third **angya Hospital, Central South University, China Tongzipo Road 138, Changsha, 410013, Hunan Province, China

      **a Cao

    5. Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao, SAR, China

      Yu-Tao **ang

    Authors
    1. Jiansong Zhou
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    2. Nailin Yao
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    3. Graeme Fairchild
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    4. **a Cao
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    5. Yingdong Zhang
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    6. Yu-Tao **ang
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    7. Li Zhang
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    8. ** Wang
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    Corresponding authors

    Correspondence to Jiansong Zhou or ** Wang.

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    All authors declare that they have no conflict of interest.

    Ethical approval

    All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was provided by all participants and their parents or guardians. The study was approved by the Biomedical Ethics Board of the second **angya Hospital, Central South University, People’s Republic of China.

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    Jiansong Zhou and Nailin Yao contributed equally to this work.

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    Zhou, J., Yao, N., Fairchild, G. et al. Disrupted default mode network connectivity in male adolescents with conduct disorder. Brain Imaging and Behavior 10, 995–1003 (2016). https://doi.org/10.1007/s11682-015-9465-6

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