Abstract
Hydroxyapatite (HA) has been widely used for coating metal bone implants. However, HA coating may separate from the metal substrates, resulting in poor performance such as inflammatory reactions which may finally lead to implant failure. Dispersing HA into metal substrate may be a viable solution but such a composite may suffer from inferior mechanical strength. Therefore, a functionally graded material (FGM) with HA dispersing in metal substrate in gradients is introduced to increase surface osteogenic capability and simultaneously maintain a good mechanical strength of the bone implant. In this study, Ti6Al4V(Ti64)-HA composite with different component of HA and their corresponding FGMs were fabricated by selective laser melting (SLM). It was demonstrated that compared with the pure Ti64 and Ti64-2.5%HA composite, Ti64-1%HA composite seemed to have a better osteogenic promoting property in vitro. Both the FGMs significantly promoted the osteogenic activities of the pure Ti64 in vivo. Moreover, functionally graded structure improved the anti-compression properties of composites.
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Acknowledgments
The authors thank Mr. Zhang Chunyu and Ms. Yan Yu of Guangdong Jianchi Biotechnology Company Limited, Dr. Eskandar Fereiduni of McMaster University, and all of the research staff members at the Department of Oral Implantology, Guanghua School of Stomatology, Sun Yat-sen University. This research was funded by the Foshan Science and Technology Innovation Project (No. 2018IT100212) and the Guangdong Provincial Science and Technology Major Project (No. 2017B090912004).
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All methods were performed in accordance with the National Research Council’s Guide for the Care and Use of Laboratory Animals. Rabbits included in this study were provided from the Animal Experiment Center of Sun Yat-sen University with the approval number of SYSU-IACUC-2021-000725.
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Lin, Y., Balbaa, M., Zeng, W. et al. Osteogenic Properties of Titanium Alloy Ti6Al4V-Hydroxyapatite Composites Fabricated by Selective Laser Melting. J. of Materi Eng and Perform (2023). https://doi.org/10.1007/s11665-023-08632-8
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DOI: https://doi.org/10.1007/s11665-023-08632-8