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Stabilizing the bactericidal activity of hydrogen peroxide: A brandnew function of certain Chinese herbs

  • Herb-Drug Interaction
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Chinese Journal of Integrative Medicine Aims and scope Submit manuscript

Abstract

Objective

To explore natural herbs to maintain the bactericidal activity of hydrogen peroxide (H).

Methods

Eighteen extracts of Chinese herbs were prepared complying with the standard protocol. Each of the solutions was then mixed with 1% H2O2. The mixtures were handled with two approaches: autoclaved daily for one, two or three times; stored at room temperature from one through five years. Then the bactericidal activity were evaluated by assaying the minimal bactericidal concentration (MBC) and minimal inhibitory concentration (MIC) against Gram positive (Staphylococcus aureus, ATCC25923) and Gram negative (Escherichia coli, ATCC12421) bacteria.

Results

While mixed with 1% H2O2, 10 out of 18 kinds of assessed Chinese herbs displayed MBC values at 1:12800 or higher after three times of autoclaving, and 8 of them preserved such level of MBC value after stored at room temperature for three years. Some Chinese herbs, i.e. R. Scutellariae, R. Coptidis, R. Bupleuri, H. Epimedii, C. Phelledendri and F. Chrysanthemi, can significantly maintain the bactericidal activity of diluted H2O2

Conclusions

Certain Chinese herbs can effectively stabilize the bactericidal activity of H2O2 undergoing autoclave or long-term storage. This paper reported a brandnew pharmaceutical function of Chinese herbs and provided experimental data for the potential enhancement of H2O2 usage while its stability level is promoted.

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Authors and Affiliations

  1. College of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China

    Wan-zhen Li  (**宛真), Ling-ling Tan  (谭玲玲), Qi-jie Li  (**启杰), Bang-**g Zhou  (周邦靖), Yong-xiang Gao  (高永翔) & Wei-jun Ding  (丁维俊)

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  1. Wan-zhen Li  (**宛真)
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  2. Ling-ling Tan  (谭玲玲)
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  3. Qi-jie Li  (**启杰)
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  4. Bang-**g Zhou  (周邦靖)
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  5. Yong-xiang Gao  (高永翔)
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  6. Wei-jun Ding  (丁维俊)
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Correspondence to Wei-jun Ding  (丁维俊).

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Li, Wz., Tan, Ll., Li, Qj. et al. Stabilizing the bactericidal activity of hydrogen peroxide: A brandnew function of certain Chinese herbs. Chin. J. Integr. Med. 20, 468–473 (2014). https://doi.org/10.1007/s11655-012-1241-5

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  • DOI: https://doi.org/10.1007/s11655-012-1241-5

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