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Biomarkers of imidacloprid toxicity in Japanese quail, Coturnix coturnix japonica

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Abstract

The in vivo effect of the oral sublethal doses of 3.014 mg kg−1 of IMI (1/25 LD50) for 1, 7, 14, and 28 days every other day on Japanese quail was investigated. The results revealed that certain biomarkers in the selected tissues of the quail such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), aminotransaminases (alanine aminotransferase, ALT, and aspartate aminotransaminase, AST), phosphatases (acid phosphatase, ACP, and alkaline phosphatase, ALP), lactate dehydrogenase (LDH), adenosine-triphosphatase (ATPase), glutathione-S-transferase (GST), lipid peroxidation (LPO), and blood glucose showed significant inductions, while significant reductions in the levels of glutathione-reduced (GSH), deoxyribonucleic acid (DNA), and ribonucleic acid (RNA) were noticed. In this study, the molecular mechanisms of the toxic effects of imidacloprid on quails were elucidated regarding neurotoxicity, hepatotoxicity, oxidative stress, lipid peroxidation, antioxidant activity, and genotoxicity. Because IMI induced alterations in the levels of these biomarkers in Japanese quail; therefore, Japanese quail as a wild avian can be used as a suite bioindicator to detect imidacloprid toxicity.

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The data presented in this study are available on request from the corresponding author. The data are not publicly available due to privacy restrictions.

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Authors and Affiliations

  1. Department of Pesticide Chemistry and Technology, Faculty of Agriculture, Alexandria University, P.O Box 21545, Alexandria, Egypt

    Khaled A. Osman, Mahmoud M. I. Shaaban & Nabila S. Ahmed

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Contributions

Study concept and design: N.S.A., K.A.O. Analysis: A.A., A.S.El. Statistical analysis: K.A.O. Drafting of the manuscript: K.A.O., N.S.A. Critical revision of the manuscript for important intellectual content: K.A.O.

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Correspondence to Khaled A. Osman.

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All animal housing, handling, breeding, and bioassays were conducted with the guidelines of the Institutional Animal Care and Use Committee (IACUC), Alexandria University, Egypt.

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Osman, K.A., Shaaban, M.M.I. & Ahmed, N.S. Biomarkers of imidacloprid toxicity in Japanese quail, Coturnix coturnix japonica. Environ Sci Pollut Res 30, 5662–5676 (2023). https://doi.org/10.1007/s11356-022-22580-1

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