Abstract
Zinc coumarate and zinc caffeinate nanoparticles (ZnCoNPs, ZnCaNPs) affect different biological processes. This study aimed to evaluate the mitigating action of ZnCoNPs in combination with ZnCaNPs against liver damage induced by gamma rays (γ-rays). Rats were exposed to 7 Gy of γ-rays and then injected intraperitoneally (i.p) with ZnCoNPs [2U/rat/day (5 mg/kg)] and ZnCaNPs [2U/rat/day (15 mg/kg)] for 7 consecutive days. The results showed that irradiated rats treated with ZnCoNPs (5 mg/kg/body weight) in combination with ZnCaNPs (15 mg/kg/body weight) for 7 days had a significant increases in body weight, antioxidant levels, T helper cell 4 (cluster of differentiation 4 (CD4)), and T cytotoxic cell 8 (cluster of differentiation 8 (CD8)), associated with a marked decrease in lipid peroxidation (LP), nitric oxide(NOx), total free radicals concentrate (TFRC), and DNA fragmentation. There were positive alterations in the morphological state, hematological parameters and the cell cycle phases. Additionally, the histopathological study demonstrated an improvement in the liver tissue of irradiated rats after treatment. Thus, ZnCoNPs and ZnCaNPs could be used as natural mitigating agents to reduce the hazards of ionizing radiation.
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References
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All authors planned the experiment. Askar MA, Mansour NA, Ali EN, Abdel-Magied N, and Ragab EA prepared the samples of tissues and nanoparticles. Guida MS prepared the samples of electrophoresis. Abu Nour SM prepared the samples for histopathological study. Elmasry SA prepared the samples for Flow Cytometry study. All authors analyzed the data. All authors read and approved the final manuscript.
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The animals’ treating procedure has been accepted by the animal ethics committee of the NCRRT subsequent the 3Rs principles for animal experimentation and is prepared by Central Scientific Publishing Committee, Egyptian Atomic Energy Authority. Rf. (190)—7/07/2020.
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Askar, M.A., Guida, M.S., AbuNour, S.M. et al. Nanoparticles for active combination radio mitigating agents of zinc coumarate and zinc caffeinate in a rat model. Environ Sci Pollut Res 29, 30233–30248 (2022). https://doi.org/10.1007/s11356-021-18411-4
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DOI: https://doi.org/10.1007/s11356-021-18411-4