Log in

Implications of sleep disorders for periodontitis

  • Sleep Breathing Physiology and Disorders • Review
  • Published:
Sleep and Breathing Aims and scope Submit manuscript

Abstract

Purpose

Periodontitis is a chronic inflammatory disease caused by multi-factors. Sleep is a natural physiologic process, and the sleep duration, quality, and patterns might be associated with periodontitis. Meanwhile, periodontitis might in turn induce systemic inflammation and thus impact sleep in different ways as well.

Methods

To investigate the bidirectional relationship between sleep disorder and periodontitis, a literature search was conducted to reveal the interaction and possible mechanism between these two diseases.

Results

The results show that sleep disorders can affect the progression of periodontitis via some pathomechanisms, and periodontitis also has a reverse impact on sleep.

Conclusion

Although the epidemiologic and clinical trials found the possible associations between sleep disorder and periodontitis, their relationship is still not that explicit. Further studies are warranted to shed light on them, to improve preventive health care.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

Data availability

My manuscript has no associated data.

References

  1. Cekici A, Kantarci A, Hasturk H (2000) Van Dyke TE (2014) Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 64(1):57–80. https://doi.org/10.1111/prd.12002

    Article  Google Scholar 

  2. Eke PI, Thornton-Evans GO, Wei L, Borgnakke WS, Dye BA, Genco RJ (2018) Periodontitis in US adults: National Health and Nutrition Examination Survey 2009–2014. J Am Dent Assoc 149(7):576-588.e576. https://doi.org/10.1016/j.adaj.2018.04.023

    Article  PubMed  PubMed Central  Google Scholar 

  3. Jiao J, **g W, Si Y, Feng X, Tai B, Hu D, Lin H, Wang B, Wang C, Zheng S, Liu X, Rong W, Wang W, Li W, Meng H, Wang X (2021) The prevalence and severity of periodontal disease in Mainland China: data from the Fourth National Oral Health Survey (2015–2016). J Clin Periodontol 48(2):168–179. https://doi.org/10.1111/jcpe.13396

    Article  PubMed  Google Scholar 

  4. The world health organization (2022) Oral health. https://www.who.int/news-room/fact-sheets/detail/oral-health. Accessed 15 March 2022

  5. Akinkugbe AA, Sharma S, Ohrbach R, Slade GD, Poole C (2016) Directed acyclic graphs for oral disease research. J Dent Res 95(8):853–859. https://doi.org/10.1177/0022034516639920

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Patel SR, Zhu X, Storfer-Isser A, Mehra R, Jenny NS, Tracy R, Redline S (2009) Sleep duration and biomarkers of inflammation. Sleep 32(2):200–204. https://doi.org/10.1093/sleep/32.2.200

    Article  PubMed  PubMed Central  Google Scholar 

  7. Dey S, Sun E, Frishman WH, Aronow WS (2022) Sleep disorders and coronary artery disease. Cardiol Rev. https://doi.org/10.1097/crd.0000000000000478

    Article  PubMed  Google Scholar 

  8. Gudkov SV, Burmistrov DE, Kondakova EV, Sarimov RM, Yarkov RS, Franceschi C, Vedunova MV (2022) An emerging role of astrocytes in aging /neuroinflammation and gut - brain axis with consequences on sleep and sleep disorders. Ageing Res Rev 83:101775. https://doi.org/10.1016/j.arr.2022.101775

  9. Sithirungson S, Sonsuwan N, Chattipakorn SC, Chattipakorn N, Shinlapawittayatorn K (2022) Functional roles of orexin in obstructive sleep apnea: From clinical observation to mechanistic insights. Sleep Med 101:40–49. https://doi.org/10.1016/j.sleep.2022.10.016

    Article  PubMed  Google Scholar 

  10. Srinivasan M, Walker C (2022) Circadian clock, glucocorticoids and NF-κB signaling in neuroinflammation- implicating glucocorticoid induced leucine zipper as a molecular link. ASN Neuro 14:17590914221120190. https://doi.org/10.1177/17590914221120190

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hirshkowitz M, Whiton K, Albert SM, Alessi C, Bruni O, DonCarlos L, Hazen N, Herman J, Katz ES, Kheirandish-Gozal L, Neubauer DN, O’Donnell AE, Ohayon M, Peever J, Rawding R, Sachdeva RC, Setters B, Vitiello MV, Ware JC, Adams Hillard PJ (2015) National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health 1(1):40–43. https://doi.org/10.1016/j.sleh.2014.12.010

    Article  PubMed  Google Scholar 

  12. Owens J (2014) Insufficient sleep in adolescents and young adults: an update on causes and consequences. Pediatrics 134(3):e921-932. https://doi.org/10.1542/peds.2014-1696

    Article  PubMed  Google Scholar 

  13. Irwin MR (2015) Why sleep is important for health: a psychoneuroimmunology perspective. Annu Rev Psychol 66:143–172. https://doi.org/10.1146/annurev-psych-010213-115205

    Article  PubMed  Google Scholar 

  14. Alhassani AA, Al-Zahrani MS (2020) Is inadequate sleep a potential risk factor for periodontitis? PLoS ONE 15(6):e0234487. https://doi.org/10.1371/journal.pone.0234487

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Alqaderi H, Goodson JM, Agaku I (2020) Association between sleep and severe periodontitis in a nationally representative adult US population. J Periodontol 91(6):767–774. https://doi.org/10.1002/jper.19-0105

    Article  PubMed  Google Scholar 

  16. Grover V, Malhotra R, Kaur H (2015) Exploring association between sleep deprivation and chronic periodontitis: a pilot study. J Indian Soc Periodontol 19(3):304–307. https://doi.org/10.4103/0972-124x.154173

    Article  PubMed  PubMed Central  Google Scholar 

  17. Karaaslan F, Dikilitaş A (2019) The association between stage-grade of periodontitis and sleep quality and oral health-related quality of life. J Periodontol 90(10):1133–1141. https://doi.org/10.1002/jper.19-0034

    Article  PubMed  Google Scholar 

  18. Nakada T, Kato T, Numabe Y (2015) Effects of fatigue from sleep deprivation on experimental periodontitis in rats. J Periodontal Res 50(1):131–137. https://doi.org/10.1111/jre.12189

    Article  CAS  PubMed  Google Scholar 

  19. Dewan NA, Nieto FJ, Somers VK (2015) Intermittent hypoxemia and OSA: implications for comorbidities. Chest 147(1):266–274. https://doi.org/10.1378/chest.14-0500

    Article  PubMed  PubMed Central  Google Scholar 

  20. Eckert DJ, White DP, Jordan AS, Malhotra A, Wellman A (2013) Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. Am J Respir Crit Care Med 188(8):996–1004. https://doi.org/10.1164/rccm.201303-0448OC

    Article  PubMed  PubMed Central  Google Scholar 

  21. Gunaratnam K, Taylor B, Curtis B, Cistulli P (2009) Obstructive sleep apnoea and periodontitis: a novel association? Sleep Breath 13(3):233–239. https://doi.org/10.1007/s11325-008-0244-0

    Article  PubMed  Google Scholar 

  22. Seo WH, Cho ER, Thomas RJ, An SY, Ryu JJ, Kim H, Shin C (2013) The association between periodontitis and obstructive sleep apnea: a preliminary study. J Periodontal Res 48(4):500–506. https://doi.org/10.1111/jre.12032

    Article  CAS  PubMed  Google Scholar 

  23. Keller JJ, Wu CS, Chen YH, Lin HC (2013) Association between obstructive sleep apnoea and chronic periodontitis: a population-based study. J Clin Periodontol 40(2):111–117. https://doi.org/10.1111/jcpe.12036

    Article  PubMed  Google Scholar 

  24. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28(2):193–213. https://doi.org/10.1016/0165-1781(89)90047-4

    Article  CAS  PubMed  Google Scholar 

  25. Singh VP, Gan JY, Liew WL, Kyaw Soe HH, Nettem S, Nettemu SK (2019) Association between quality of sleep and chronic periodontitis: a case-control study in Malaysian population. Dent Res J (Isfahan) 16(1):29–35

    Article  PubMed  Google Scholar 

  26. Park JS, Jeong Y, Jung J, Ryu JJ, Lim HK, Jung SK, Song IS (2021) Shift work sleep disorder is closely associated with an increased risk for periodontal disease. J Clin Periodontol 48(8):1066–1075. https://doi.org/10.1111/jcpe.13508

    Article  PubMed  Google Scholar 

  27. Sato F, Sato H, ** D, Bhawal UK, Wu Y, Noshiro M, Kawamoto T, Fujimoto K, Seino H, Morohashi S, Kato Y, Kijima H (2012) Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver. Biochem Biophys Res Commun 419(2):441–446. https://doi.org/10.1016/j.bbrc.2012.02.076

    Article  CAS  PubMed  Google Scholar 

  28. Fujihara Y, Kondo H, Noguchi T, Togari A (2014) Glucocorticoids mediate circadian timing in peripheral osteoclasts resulting in the circadian expression rhythm of osteoclast-related genes. Bone 61:1–9. https://doi.org/10.1016/j.bone.2013.12.026

    Article  CAS  PubMed  Google Scholar 

  29. Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk HD, Kramer A, Maier B (2009) A circadian clock in macrophages controls inflammatory immune responses. Proc Natl Acad Sci U S A 106(50):21407–21412. https://doi.org/10.1073/pnas.0906361106

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Han DH, Khang YH, Jung-Choi K, Lim S (2013) Association between shift work and periodontal health in a representative sample of an Asian population. Scand J Work Environ Health 39(6):559–567. https://doi.org/10.5271/sjweh.3370

    Article  PubMed  Google Scholar 

  31. Wei T, Li C, Heng Y, Gao X, Zhang G, Wang H, Zhao X, Meng Z, Zhang Y, Hou H (2020) Association between night-shift work and level of melatonin: systematic review and meta-analysis. Sleep Med 75:502–509. https://doi.org/10.1016/j.sleep.2020.09.018

    Article  PubMed  Google Scholar 

  32. Chitimus DM, Popescu MR, Voiculescu SE, Panaitescu AM, Pavel B, Zagrean L, Zagrean AM (2020) Melatonin’s impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease. Biomolecules 10(9):1211. https://doi.org/10.3390/biom10091211

  33. Carrasco C, Marchena AM, Holguín-Arévalo MS, Martín-Partido G, Rodríguez AB, Paredes SD, Pariente JA (2013) Anti-inflammatory effects of melatonin in a rat model of caerulein-induced acute pancreatitis. Cell Biochem Funct 31(7):585–590. https://doi.org/10.1002/cbf.2942

    Article  CAS  PubMed  Google Scholar 

  34. Romandini M, Gioco G, Perfetti G, Deli G, Staderini E, Laforì A (2017) The association between periodontitis and sleep duration. J Clin Periodontol 44(5):490–501. https://doi.org/10.1111/jcpe.12713

    Article  PubMed  Google Scholar 

  35. Han DH, Kim MS, Kim S, Yoo JW, Shen JJ (2022) Sleep time and duration are associated with periodontitis in a representative sample of Koreans. J Periodontol 93(2):208–217. https://doi.org/10.1002/jper.20-0252

    Article  CAS  PubMed  Google Scholar 

  36. Lee DH, Lee YH (2017) Association between sleep duration, dental caries, and periodontitis in Korean adults: the Korea National Health and Nutrition Examination Survey, 2013–2014. Korean Soc Dent Hyg Sci 17(1):38–45. https://doi.org/10.17135/jdhs.2017.17.1.38

  37. Pink C, Kocher T, Meisel P, Dörr M, Markus MR, Jablonowski L, Grotevendt A, Nauck M, Holtfreter B (2015) Longitudinal effects of systemic inflammation markers on periodontitis. J Clin Periodontol 42(11):988–997. https://doi.org/10.1111/jcpe.12473

    Article  CAS  PubMed  Google Scholar 

  38. Dowd JB, Goldman N, Weinstein M (2011) Sleep duration, sleep quality, and biomarkers of inflammation in a Taiwanese population. Ann Epidemiol 21(11):799–806. https://doi.org/10.1016/j.annepidem.2011.07.004

    Article  PubMed  PubMed Central  Google Scholar 

  39. Islam MM, Ekuni D, Toyama N, Taniguchi-Tabata A, Kataoka K, Uchida-Fukuhara Y, Fukuhara D, Saho H, Sawada N, Nakashima Y, Iwasaki Y, Morita M (2020) Association between sleep quality and duration and periodontal disease among university students: a cross-sectional study. Int J Environ Res Public Health 17(9):3034. https://doi.org/10.3390/ijerph17093034

  40. Saletu A, Pirker-Frühauf H, Saletu F, Linzmayer L, Anderer P, Matejka M (2005) Controlled clinical and psychometric studies on the relation between periodontitis and depressive mood. J Clin Periodontol 32(12):1219–1225. https://doi.org/10.1111/j.1600-051X.2005.00855.x

    Article  PubMed  Google Scholar 

  41. Han K, Park JB (2018) Evaluation of the association between sleep duration and tooth loss among Korean adults: data from the Korean National Health and Nutrition Examination Survey (KNHANES 2012–2014). BMJ Open 8(5):e018383. https://doi.org/10.1136/bmjopen-2017-018383

    Article  PubMed  PubMed Central  Google Scholar 

  42. Wang Y, Andrukhov O, Rausch-Fan X (2017) Oxidative stress and antioxidant system in periodontitis. Front Physiol 8:910. https://doi.org/10.3389/fphys.2017.00910

    Article  PubMed  PubMed Central  Google Scholar 

  43. Stanek A, Brożyna-Tkaczyk K, Myśliński W (2021) Oxidative stress markers among obstructive sleep apnea patients. Oxid Med Cell Longev 2021:9681595. https://doi.org/10.1155/2021/9681595

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Hall TJ, Schaeublin M, Jeker H, Fuller K, Chambers TJ (1995) The role of reactive oxygen intermediates in osteoclastic bone resorption. Biochem Biophys Res Commun 207(1):280–287. https://doi.org/10.1006/bbrc.1995.1184

    Article  CAS  PubMed  Google Scholar 

  45. Zhu R, Mi X, Li Y (2022) Effects of hypoxic environment on periodontal tissue through the ROS/TXNIP/NLRP3 inflammasome pathway. Biomed Res Int 2022:7690960. https://doi.org/10.1155/2022/7690960

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. DeMartino T, Ghoul RE, Wang L, Bena J, Hazen SL, Tracy R, Patel SR, Auckley D, Mehra R (2016) Oxidative stress and inflammation differentially elevated in objective versus habitual subjective reduced sleep duration in obstructive sleep apnea. Sleep 39(7):1361–1369. https://doi.org/10.5665/sleep.5964

    Article  PubMed  PubMed Central  Google Scholar 

  47. Chapple IL (2000) Matthews JB (2007) The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 43:160–232. https://doi.org/10.1111/j.1600-0757.2006.00178.x

    Article  Google Scholar 

  48. Kanagasabai T, Ardern CI (2015) Contribution of inflammation, oxidative stress, and antioxidants to the relationship between sleep duration and cardiometabolic health. Sleep 38(12):1905–1912. https://doi.org/10.5665/sleep.5238

    Article  PubMed  PubMed Central  Google Scholar 

  49. Ikeda-Sagara M, Ikeda M (2007) Oxidative stress and sleep homeostasis. Nihon Yakurigaku Zasshi 129(6):404–407. https://doi.org/10.1254/fpj.129.404

    Article  CAS  PubMed  Google Scholar 

  50. Sehirli A, Chukwunyere U, Aksoy U, Sayiner S, Abacioglu N (2021) The circadian clock gene Bmal1: role in COVID-19 and periodontitis. Chronobiol Int 38(6):779–784. https://doi.org/10.1080/07420528.2021.1895198

    Article  CAS  PubMed  Google Scholar 

  51. Irwin MR, Wang M, Ribeiro D, Cho HJ, Olmstead R, Breen EC, Martinez-Maza O, Cole S (2008) Sleep loss activates cellular inflammatory signaling. Biol Psychiatry 64(6):538–540. https://doi.org/10.1016/j.biopsych.2008.05.004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Gölz L, Memmert S, Rath-Deschner B, Jäger A, Appel T, Baumgarten G, Götz W, Frede S (2015) Hypoxia and P. gingivalis synergistically induce HIF-1 and NF-κB activation in PDL cells and periodontal diseases. Mediators Inflamm 2015:438085. https://doi.org/10.1155/2015/438085

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Brandt JA, Churchill L, Rehman A, Ellis G, Mémet S, Israël A, Krueger JM (2004) Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells. Brain Res 1004(1–2):91–97. https://doi.org/10.1016/j.brainres.2003.11.079

    Article  CAS  PubMed  Google Scholar 

  54. Basheer R, Rainnie DG, Porkka-Heiskanen T, Ramesh V, McCarley RW (2001) Adenosine, prolonged wakefulness, and A1-activated NF-kappaB DNA binding in the basal forebrain of the rat. Neuroscience 104(3):731–739. https://doi.org/10.1016/s0306-4522(01)00111-7

    Article  CAS  PubMed  Google Scholar 

  55. Papathanasiou E, Conti P, Carinci F, Lauritano D, Theoharides TC (2020) IL-1 superfamily members and periodontal diseases. J Dent Res 99(13):1425–1434. https://doi.org/10.1177/0022034520945209

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Pan W, Wang Q, Chen Q (2019) The cytokine network involved in the host immune response to periodontitis. Int J Oral Sci 11(3):30. https://doi.org/10.1038/s41368-019-0064-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Wang Y, Huang X, He F (2019) Mechanism and role of nitric oxide signaling in periodontitis. Exp Ther Med 18(5):3929–3935. https://doi.org/10.3892/etm.2019.8044

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. O’Shea JJ, Murray PJ (2008) Cytokine signaling modules in inflammatory responses. Immunity 28(4):477–487. https://doi.org/10.1016/j.immuni.2008.03.002

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Aaronson DS, Horvath CM (2002) A road map for those who don’t know JAK-STAT. Science 296(5573):1653–1655. https://doi.org/10.1126/science.1071545

    Article  CAS  PubMed  Google Scholar 

  60. Gomes Galvani M, Moreira Antunes HK, Monico-Neto M, Yujra VQ, Prado CM, Quintana HT, de Oliveira F, Ribeiro DA (2021) Sleep deprivation interferes with JAK/STAT signaling pathway and myogenesis in the masseter muscle of rats. Med Princ Pract 30(3):253–261. https://doi.org/10.1159/000515307

    Article  PubMed  PubMed Central  Google Scholar 

  61. Li J, Li L, Wang X, **ao L (2020) Porphyromonas gingivalis Inhibition of MicroRNA-205-5p expression modulates proinflammatory cytokines in gingival epithelial cells. Biochem Genet 58(4):566–579. https://doi.org/10.1007/s10528-020-09957-y

    Article  CAS  PubMed  Google Scholar 

  62. de Souza JA, Nogueira AV, de Souza PP, Cirelli JA, Garlet GP, Rossa C Jr (2011) Expression of suppressor of cytokine signaling 1 and 3 in ligature-induced periodontitis in rats. Arch Oral Biol 56(10):1120–1128. https://doi.org/10.1016/j.archoralbio.2011.03.022

    Article  CAS  PubMed  Google Scholar 

  63. Han YK, Lee IS, Lee SI (2017) JAK/STAT Pathway modulates on porphyromonas gingivalis lipopolysaccharide- and nicotine-induced inflammation in osteoblasts. J Dent Hyg Sci 17(1):81–86

    Article  Google Scholar 

  64. Masoud GN, Li W (2015) HIF-1α pathway: role, regulation and intervention for cancer therapy. Acta Pharm Sin B 5(5):378–389. https://doi.org/10.1016/j.apsb.2015.05.007

    Article  PubMed  PubMed Central  Google Scholar 

  65. Gabryelska A, Szmyd B, Szemraj J, Stawski R, Sochal M, Białasiewicz P (2020) Patients with obstructive sleep apnea present with chronic upregulation of serum HIF-1α protein. J Clin Sleep Med 16(10):1761–1768. https://doi.org/10.5664/jcsm.8682

    Article  PubMed  PubMed Central  Google Scholar 

  66. Hajishengallis G (2015) Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 15(1):30–44. https://doi.org/10.1038/nri3785

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Sorsa T, Tjäderhane L, Konttinen YT, Lauhio A, Salo T, Lee HM, Golub LM, Brown DL, Mäntylä P (2006) Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med 38(5):306–321. https://doi.org/10.1080/07853890600800103

    Article  CAS  PubMed  Google Scholar 

  68. Liu W, Zhang W, Wang T, Wu J, Zhong X, Gao K, Liu Y, He X, Zhou Y, Wang H, Zeng H (2019) Obstructive sleep apnea syndrome promotes the progression of aortic dissection via a ROS- HIF-1α-MMPs associated pathway. Int J Biol Sci 15(13):2774–2782. https://doi.org/10.7150/ijbs.34888

    Article  PubMed  PubMed Central  Google Scholar 

  69. Song ZC, Zhou W, Shu R, Ni J (2012) Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through HIF-1α pathway. Cell Prolif 45(3):239–248. https://doi.org/10.1111/j.1365-2184.2012.00810.x

    Article  CAS  PubMed  Google Scholar 

  70. Yu X, Jiang H, Cheng G, Shang W, Zhang S (2020) High levels of HIF-1ɑ in hypoxic dental pulps associated with teeth with severe periodontitis. J Mol Histol 51(3):265–275. https://doi.org/10.1007/s10735-020-09878-5

    Article  CAS  PubMed  Google Scholar 

  71. Byun JI, Cha KS, Jun JE, Kim TJ, Jung KY, Jeong IK, Shin WC (2020) Dynamic changes in nocturnal blood glucose levels are associated with sleep-related features in patients with obstructive sleep apnea. Sci Rep 10(1):17877. https://doi.org/10.1038/s41598-020-74908-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Twedt R, Bradley M, Deiseroth D, Althouse A, Facco F (2015) Sleep duration and blood glucose control in women with gestational diabetes mellitus. Obstet Gynecol 126(2):326–331. https://doi.org/10.1097/aog.0000000000000959

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Spiegel K, Knutson K, Leproult R, Tasali E (1985) Van Cauter E (2005) Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes. J Appl Physiol 99(5):2008–2019. https://doi.org/10.1152/japplphysiol.00660.2005

    Article  CAS  Google Scholar 

  74. Gottlieb DJ, Punjabi NM, Newman AB, Resnick HE, Redline S, Baldwin CM, Nieto FJ (2005) Association of sleep time with diabetes mellitus and impaired glucose tolerance. Arch Intern Med 165(8):863–867. https://doi.org/10.1001/archinte.165.8.863

    Article  PubMed  Google Scholar 

  75. Miranda TS, Heluy SL, Cruz DF, da Silva HDP, Feres M, Figueiredo LC, Duarte PM (2019) The ratios of pro-inflammatory to anti-inflammatory cytokines in the serum of chronic periodontitis patients with and without type 2 diabetes and/or smoking habit. Clin Oral Investig 23(2):641–650. https://doi.org/10.1007/s00784-018-2471-5

    Article  PubMed  Google Scholar 

  76. Hall MH, Muldoon MF, Jennings JR, Buysse DJ, Flory JD, Manuck SB (2008) Self-reported sleep duration is associated with the metabolic syndrome in midlife adults. Sleep 31(5):635–643. https://doi.org/10.1093/sleep/31.5.635

    Article  PubMed  PubMed Central  Google Scholar 

  77. Hasler G, Buysse DJ, Klaghofer R, Gamma A, Ajdacic V, Eich D, Rössler W, Angst J (2004) The association between short sleep duration and obesity in young adults: a 13-year prospective study. Sleep 27(4):661–666. https://doi.org/10.1093/sleep/27.4.661

    Article  PubMed  Google Scholar 

  78. Taheri S (2006) The link between short sleep duration and obesity: we should recommend more sleep to prevent obesity. Arch Dis Child 91(11):881–884. https://doi.org/10.1136/adc.2005.093013

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Wu Y, Zhai L, Zhang D (2014) Sleep duration and obesity among adults: a meta-analysis of prospective studies. Sleep Med 15(12):1456–1462. https://doi.org/10.1016/j.sleep.2014.07.018

    Article  PubMed  Google Scholar 

  80. Marshall NS, Glozier N, Grunstein RR (2008) Is sleep duration related to obesity? A critical review of the epidemiological evidence. Sleep Med Rev 12(4):289–298. https://doi.org/10.1016/j.smrv.2008.03.001

    Article  PubMed  Google Scholar 

  81. Pico-Orozco J, Silvestre FJ, Carrasco-Llatas M, Silvestre-Rangil J (2021) Influence of body mass index and obesity upon the association between periodontitis and sleep apnea-hypopnea syndrome. Clin Oral Investig 25(6):3929–3935. https://doi.org/10.1007/s00784-020-03722-6

    Article  PubMed  Google Scholar 

  82. Han Y, Huang Y, Gao P, Yang Q, Jia L, Zheng Y, Li W (2022) Leptin aggravates periodontitis by promoting M1 polarization via NLRP3. J Dent Res 101(6):675–685. https://doi.org/10.1177/00220345211059418

    Article  CAS  PubMed  Google Scholar 

  83. Yılmaz G, Kırzıoğlu FY, Doğuç DK, Koçak H, Orhan H (2014) Ghrelin levels in chronic periodontitis patients. Odontology 102(1):59–67. https://doi.org/10.1007/s10266-012-0100-3

    Article  CAS  PubMed  Google Scholar 

  84. Cancello R, Clément K (2006) Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG 113(10):1141–1147. https://doi.org/10.1111/j.1471-0528.2006.01004.x

    Article  CAS  PubMed  Google Scholar 

  85. ** B, He D, Zhang M, Xue J, Zhou D (2014) Short sleep duration predicts risk of metabolic syndrome: a systematic review and meta-analysis. Sleep Med Rev 18(4):293–297. https://doi.org/10.1016/j.smrv.2013.06.001

    Article  PubMed  Google Scholar 

  86. Li P, He L, Sha YQ, Luan QX (2009) Relationship of metabolic syndrome to chronic periodontitis. J Periodontol 80(4):541–549. https://doi.org/10.1902/jop.2009.080387

    Article  PubMed  Google Scholar 

  87. Li Y, Lu Z, Zhang X, Yu H, Kirkwood KL, Lopes-Virella MF, Huang Y (2015) Metabolic syndrome exacerbates inflammation and bone loss in periodontitis. J Dent Res 94(2):362–370. https://doi.org/10.1177/0022034514561658

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Cohen S, Janicki-Deverts D, Miller GE (2007) Psychological stress and disease. Jama J Am Med Assoc 298(14):1685–1687. https://doi.org/10.1001/jama.298.14.1685

    Article  CAS  Google Scholar 

  89. Segerstrom SC, Miller GE (2004) Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull 130(4):601–630. https://doi.org/10.1037/0033-2909.130.4.601

    Article  PubMed  PubMed Central  Google Scholar 

  90. Burke HM, Davis MC, Otte C, Mohr DC (2005) Depression and cortisol responses to psychological stress: a meta-analysis. Psychoneuroendocrinology 30(9):846–856. https://doi.org/10.1016/j.psyneuen.2005.02.010

    Article  CAS  PubMed  Google Scholar 

  91. Tomfohr LM, Edwards KM, Dimsdale JE (2012) Is obstructive sleep apnea associated with cortisol levels? A systematic review of the research evidence. Sleep Med Rev 16(3):243–249. https://doi.org/10.1016/j.smrv.2011.05.003

    Article  PubMed  Google Scholar 

  92. Schwarz J, Gerhardsson A, van Leeuwen W, Lekander M, Ericson M, Fischer H, Kecklund G, Åkerstedt T (2018) Does sleep deprivation increase the vulnerability to acute psychosocial stress in young and older adults? Psychoneuroendocrinology 96:155–165. https://doi.org/10.1016/j.psyneuen.2018.06.003

    Article  PubMed  Google Scholar 

  93. Hilgert JB, Hugo FN, Bandeira DR, Bozzetti MC (2006) Stress, cortisol, and periodontitis in a population aged 50 years and over. J Dent Res 85(4):324–328. https://doi.org/10.1177/154405910608500408

    Article  CAS  PubMed  Google Scholar 

  94. Obulareddy VT, Chava VK, Nagarakanti S (2018) Association of stress, salivary cortisol, and chronic periodontitis: a clinico-biochemical study. Contemp Clin Dent 9(Suppl 2):S299-s304. https://doi.org/10.4103/ccd.ccd_289_18

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Refulio Z, Rocafuerte M, de la Rosa M, Mendoza G, Chambrone L (2013) Association among stress, salivary cortisol levels, and chronic periodontitis. J Periodontal Implant Sci 43(2):96–100. https://doi.org/10.5051/jpis.2013.43.2.96

    Article  PubMed  PubMed Central  Google Scholar 

  96. Crowley SJ, Acebo C, Carskadon MA (2007) Sleep, circadian rhythms, and delayed phase in adolescence. Sleep Med 8(6):602–612. https://doi.org/10.1016/j.sleep.2006.12.002

    Article  PubMed  Google Scholar 

  97. Chellappa SL, Engen PA, Naqib A, Qian J, Vujovic N, Rahman N, Green SJ, Garaulet M, Keshavarzian A, Scheer F (2022) Proof-of-principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota. Faseb j 36(1):e22043. https://doi.org/10.1096/fj.202101153R

    Article  CAS  PubMed  Google Scholar 

  98. Takayasu L, Suda W, Takanashi K, Iioka E, Kurokawa R, Shindo C, Hattori Y, Yamashita N, Nishijima S, Oshima K, Hattori M (2017) Circadian oscillations of microbial and functional composition in the human salivary microbiome. DNA Res 24(3):261–270. https://doi.org/10.1093/dnares/dsx001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Navara KJ, Nelson RJ (2007) The dark side of light at night: physiological, epidemiological, and ecological consequences. J Pineal Res 43(3):215–224. https://doi.org/10.1111/j.1600-079X.2007.00473.x

    Article  CAS  PubMed  Google Scholar 

  100. Murakami Y, Yuhara K, Takada N, Arai T, Tsuda S, Takamatsu S, Machino M, Fujisawa S (2011) Effect of melatonin on cyclooxygenase-2 expression and nuclear factor-kappa B activation in RAW264.7 macrophage-like cells stimulated with fimbriae of Porphyromonas gingivalis. In Vivo 25(4):641–647

    CAS  PubMed  Google Scholar 

  101. Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE (2005) Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 43(11):5721–5732. https://doi.org/10.1128/jcm.43.11.5721-5732.2005

    Article  PubMed  PubMed Central  Google Scholar 

  102. Nizam N, Basoglu OK, Tasbakan MS, Lappin DF, Buduneli N (2016) Is there an association between obstructive sleep apnea syndrome and periodontal inflammation? Clin Oral Investig 20(4):659–668. https://doi.org/10.1007/s00784-015-1544-y

    Article  CAS  PubMed  Google Scholar 

  103. Chen Y, Chen X, Huang X, Duan Y, Gao H, Gao X (2021) Analysis of salivary microbiome and its association with periodontitis in patients with obstructive sleep apnea. Front Cell Infect Microbiol 11:752475. https://doi.org/10.3389/fcimb.2021.752475

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. Ko CY, Hu AK, Chou D, Huang LM, Su HZ, Yan FR, Zhang XB, Zhang HP, Zeng YM (2019) Analysis of oral microbiota in patients with obstructive sleep apnea-associated hypertension. Hypertens Res 42(11):1692–1700. https://doi.org/10.1038/s41440-019-0260-4

    Article  PubMed  PubMed Central  Google Scholar 

  105. Magliulo G, Iannella G, Ciofalo A, Polimeni A, De Vincentiis M, Pasquariello B, Montevecchi F, Vicini C (2019) Nasal pathologies in patients with obstructive sleep apnoea. Acta Otorhinolaryngol Ital 39(4):250–256. https://doi.org/10.14639/0392-100x-2173

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  106. Gottlieb DJ, Punjabi NM (2020) Diagnosis and management of obstructive sleep apnea: a review. JAMA 323(14):1389–1400. https://doi.org/10.1001/jama.2020.3514

    Article  PubMed  Google Scholar 

  107. Cartee DL, Maker S, Dalonges D, Manski MC (2015) Sjögren’s syndrome: oral manifestations and treatment, a dental perspective. J Dent Hyg 89(6):365–371

    PubMed  Google Scholar 

  108. D’Aiuto F, Parkar M, Andreou G, Suvan J, Brett PM, Ready D, Tonetti MS (2004) Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. J Dent Res 83(2):156–160. https://doi.org/10.1177/154405910408300214

    Article  PubMed  Google Scholar 

  109. Cardoso EM, Reis C, Manzanares-Céspedes MC (2018) Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases. Postgrad Med 130(1):98–104. https://doi.org/10.1080/00325481.2018.1396876

    Article  PubMed  Google Scholar 

  110. Krueger JM (2008) The role of cytokines in sleep regulation. Curr Pharm Des 14(32):3408–3416. https://doi.org/10.2174/138161208786549281

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  111. Späth-Schwalbe E, Hansen K, Schmidt F, Schrezenmeier H, Marshall L, Burger K, Fehm HL, Born J (1998) Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men. J Clin Endocrinol Metab 83(5):1573–1579. https://doi.org/10.1210/jcem.83.5.4795

    Article  PubMed  Google Scholar 

  112. Friedman EM, Hayney MS, Love GD, Urry HL, Rosenkranz MA, Davidson RJ, Singer BH, Ryff CD (2005) Social relationships, sleep quality, and interleukin-6 in aging women. Proc Natl Acad Sci U S A 102(51):18757–18762. https://doi.org/10.1073/pnas.0509281102

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. Okun ML, Coussons-Read M, Hall M (2009) Disturbed sleep is associated with increased C-reactive protein in young women. Brain Behav Immun 23(3):351–354. https://doi.org/10.1016/j.bbi.2008.10.008

    Article  CAS  PubMed  Google Scholar 

  114. Liu R, Liu X, Zee PC, Hou L, Zheng Z, Wei Y, Du J (2014) Association between sleep quality and C-reactive protein: results from national health and nutrition examination survey, 2005–2008. PLoS ONE 9(3):e92607. https://doi.org/10.1371/journal.pone.0092607

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Funding

Science & Technology Department of Sichuan Province provided financial support in the form of Sichuan Science and Technology Program (No.2022NSFSC1521). The sponsor had no role in the design or conduct of this research.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yang **gmei.

Ethics declarations

Ethical approval

This article does not contain any studies with human participants performed by any of the authors.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, L., Nini, W., **mei, Z. et al. Implications of sleep disorders for periodontitis. Sleep Breath 27, 1655–1666 (2023). https://doi.org/10.1007/s11325-022-02769-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11325-022-02769-x

Keywords

Navigation