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Clinical significance of plasma mannose concentrations in healthy and diabetic dogs

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Abstract

Circulating levels of monosaccharides can act as a reflection of systemic glucose/ energy metabolism. Characteristic changes observed in these levels can be seen in patients with diabetes and other metabolic disorders. There have been a few reports describing the significance of mannose metabolism as an energy source under physiological and pathological conditions. However, the relationship between circulating levels of mannose and the pathophysiology of diabetes mellitus are unknown in dogs. This study examined circulating levels of mannose between healthy control and diabetic dogs and evaluated the clinical significance of mannose levels in dogs. Diabetic dogs demonstrated a higher circulating level of mannose in comparison to normal healthy control dogs. Plasma mannose was positively correlated with plasma glucose and fructosamine, respectively. Interestingly, plasma mannose levels were affected by plasma insulin levels. In the context of feeding and glucose tolerance tests, plasma mannose levels responded to changes in circulating insulin levels. Circulating plasma mannose levels decreased after feeding in both control and diabetic animals in spite of observed insulin level differences. However, when glucose tolerance tests were given, a positive correlation between mannose levels and insulin levels was observed. Therefore, plasma mannose levels obtained via glucose tolerance testing may be used as a new diagnostic method for evaluating insulin resistance or deficiency in diabetic dogs.

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Abbreviations

BCS:

body condition score

BW:

body weight

DM:

diabetes mellitus

FPG:

fasting plasma glucose

[glucose]:

glucose concentration

HPLC:

high-performance liquid chromatography

IGT:

impaired glucose tolerance

[insulin]:

insulin concentration

IVGTT:

intravenous glucose tolerance test

[mannose]:

mannose concentration

RER:

resting energy requirement

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Acknowledgments

This work was supported in part by the ‘Academic Frontier’ Project Grant for Private Universities awarded from Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT), 2005–2009.

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Authors and Affiliations

  1. Department of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan

    A. Mori, T. Sato, P. Lee, M. Furuuchi, H. Tazaki, K. Katayama, H. Mizutani & T. Arai

  2. Department of Veterinary Nursing, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan

    T. Sako

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  1. A. Mori
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  2. T. Sato
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  3. P. Lee
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  4. M. Furuuchi
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  5. H. Tazaki
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  6. K. Katayama
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  9. T. Arai
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Correspondence to A. Mori.

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Mori, A., Sato, T., Lee, P. et al. Clinical significance of plasma mannose concentrations in healthy and diabetic dogs. Vet Res Commun 33, 439–451 (2009). https://doi.org/10.1007/s11259-008-9190-3

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  • DOI: https://doi.org/10.1007/s11259-008-9190-3

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