Abstract
A simple, efficient, and eco-friendly protocol for the synthesis of 1,3-oxazine derivatives, viz. 7-aryl-7,8-dihydro-6H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-e][1,3]oxazines and 3-aryl-3,4-dihydro-2H- naphtho[2,3-e][1,3]oxazine-5,10-diones, involving one-pot multicomponent condensation reaction of various amines and formaldehyde with sesamol/2-hydroxy-1,4-naphthoquinone, respectively, catalyzed by a choline chloride–oxalic acid deep eutectic solvent has been developed. The method offers several advantages, including mild reaction conditions, simple operating procedure, recyclable and biodegradable catalyst, short reaction times, and excellent yields of the target products.
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Chaudhary, A., Khanna, G., Chopra, H. et al. Deep eutectic solvent-mediated expedient multicomponent synthesis of oxazine scaffolds. Res Chem Intermed 48, 2267–2278 (2022). https://doi.org/10.1007/s11164-022-04674-0
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DOI: https://doi.org/10.1007/s11164-022-04674-0