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Progress, challenges and perspectives in the management of hypopituitarism

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Abstract

Hypopituitarism is a rare endocrine disorder characterized by insufficient hormone secretion from the pituitary gland. This condition leads to deficient production of one or more pituitary hormones, including growth hormone (GH), thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), adrenocorticotropic hormone (ACTH), and antidiuretic hormone (ADH), also called arginine vasopressin (AVP). Symptoms vary widely and are often not, late recognized.

Diagnosis typically involves a thorough clinical evaluation, hormone level assessments, and neuroimaging studies to identify underlying causes. Treatment aims to replace deficient hormones and address the underlying cause and related complications when possible. In this special issue we address diagnosis, comorbidities, and management of hypopituitarism. We hope that it will help healthcare professionals to manage their patients.

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Data supporting this Editorial are included in the special issue of REMD “Progress, challenges and perspectives in the management of hypopituitarism”.

References

  1. Garmes HM, Boguszewski CL, Miranda PAC, Martins MRA, da Silva SRC, Abucham JZ, de Filho NR, Vilar L, Portari LHC, Gadelha MR, Kasuki L, Naves LA, Czepielewski MA, de Almeida TS, Duarte FHG, Glezer A, Bronstein MD. Management of hypopituitarism: a perspective from the Brazilian society of Endocrinology and Metabolism. Arch Endocrinol Metab. 2021;65(2):212–30. https://doi.org/10.20945/2359-3997000000335.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Fleseriu M, Hashim IA, Karavitaki N, Melmed S, Murad MH, Salvatori R, Samuels MH. Hormonal replacement in hypopituitarism in adults: an endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(11):3888–921. https://doi.org/10.1210/jc.2016-2118.

    Article  CAS  PubMed  Google Scholar 

  3. Sherlock M, Ayuk J, Tomlinson JW, Toogood AA, Aragon-Alonso A, Sheppard MC, Bates AS, Stewart PM. Mortality in patients with pituitary disease. Endocr Rev. 2010;31(3):301–42. https://doi.org/10.1210/er.2009-0033.

    Article  PubMed  Google Scholar 

  4. Matsumoto R, Takahashi Y. Human pituitary development and application of iPSCs for pituitary disease. Cell Mol Life Sci. 2021;78(5):2069–79. https://doi.org/10.1007/s00018-020-03692-8.

    Article  CAS  PubMed  Google Scholar 

  5. Donato J Jr, Kopchick JJ. New findings on brain actions of growth hormone and potential clinical implications. Rev Endocr Metab Disord 2023 Dec 7. https://doi.org/10.1007/s11154-023-09861-x.

  6. Yuen KCJ, Biller BMK, Radovick S, Carmichael JD, Jasim S, Pantalone KM, Hoffman AR. American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for management of growth hormone Deficiency in adults and patients transitioning from pediatric to adult care. Endocr Pract. 2019;25(11):1191–232. https://doi.org/10.4158/GL-2019-0405.

    Article  PubMed  Google Scholar 

  7. Garmes HM. Special features on insulin resistance, metabolic syndrome and vascular complications in hypopituitary patients. Rev Endocr Metab Disord 2024 Jan 25. https://doi.org/10.1007/s11154-023-09872-8.

  8. Schilbach K, Bidlingmaier M. Pitfalls in the lab assessment of hypopituitarism. xxxxxx Rev Endocr Metab Disord. 2024. Xxxx.

  9. Rey RA, Bergadá I, Ballerini MG, Braslavsky D, Chiesa A, Freire A, Grinspon RP, Keselman A, Arcari A. Diagnosing and treating anterior pituitary hormone deficiency in pediatric patients. Rev Endocr Metab Disord 2023 Dec 19. https://doi.org/10.1007/s11154-023-09868-4.

  10. Corsello A, Paragliola RM, Salvatori R. Diagnosing and treating the elderly individual with hypopituitarism. Rev Endocr Metab Disord 2023 Dec 27. https://doi.org/10.1007/s11154-023-09870-w.

  11. Esposito D, Tivesten Å, Olivius C, Ragnarsson O, Johannsson G. Androgen deficiency in hypopituitary women: its consequences and management. Rev Endocr Metab Disord 2024 Jan 19. https://doi.org/10.1007/s11154-024-09873-1.

  12. Marques JVO, Boguszewski CL. Fertility issues in aggressive pituitary tumors. Rev Endocr Metab Disord. 2020;21(2):225–33. https://doi.org/10.1007/s11154-019-09530-y.

    Article  CAS  PubMed  Google Scholar 

  13. Chen J, Chang JJ, Chung EH, Lathi RB, Aghajanova L, Katznelson L. Fertility issues in hypopituitarism. Rev Endocr Metab Disord 2023 Dec 14. https://doi.org/10.1007/s11154-023-09863-9.

  14. Kuliczkowska-Płaksej J, Zdrojowy-Wełna A, Jawiarczyk-Przybyłowska A, Gojny L, Bolanowski M. Diagnosis and therapeutic approach to bone health in patients with hypopituitarism. xxxxxx Rev Endocr Metab Disord. 2024. Xxxx.

  15. Abucham J, Martins M. Subclinical central hypothyroidism in patients with hypothalamic-pituitary disease: does it exist? Rev Endocr Metab Disord 2024 Feb 7. https://doi.org/10.1007/s11154-024-09876-y.

  16. Martel-Duguech L, Poirier J, Bourdeau I, Lacroix A. Diagnosis and management of secondary adrenal crisis. Rev Endocr Metab Disord 2024 Feb 27. https://doi.org/10.1007/s11154-024-09877-x.

  17. Fahim Ebrahimi F, Andereggen L, Christ ER. Morbidities and mortality among hospitalized patients with hypopituitarism: prevalence, causes and management. Xxxx: xxxxxx Rev Endocr Metab Disord; 2024.

    Google Scholar 

  18. Refardt J, Atila C, Christ-Crain M. New insights on diagnosis and treatment of AVP deficiency. Rev Endocr Metab Disord 2023 Dec 13. https://doi.org/10.1007/s11154-023-09862-w.

  19. Imran SA, Wilkinson M. Cognition and psychological wellbeing in hypopituitary patients. Rev Endocr Metab Disord. 2023 Dec;26. https://doi.org/10.1007/s11154-023-09869-3.

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Authors and Affiliations

  1. Endocrine Division (SEMPR), Department of Internal Medicine, Federal University of parana, Curitiba, Brazil

    Cesar Luiz Boguszewski

  2. Department of Medicine, Division of Endocrinology, Erasmus University Medical Center, Rotterdam, The Netherlands

    Sebastian Neggers

  3. SEMPR, Serviço de Endocrinologia e Metabologia do Hospital de Clínicas da Universidade Federal do Paraná, Avenida Agostinho Leão Junior, 285, 80030-110, Curitiba, PR, Brazil

    Cesar Luiz Boguszewski

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Correspondence to Cesar Luiz Boguszewski.

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Boguszewski, C.L., Neggers, S. Progress, challenges and perspectives in the management of hypopituitarism. Rev Endocr Metab Disord 25, 453–455 (2024). https://doi.org/10.1007/s11154-024-09889-7

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