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Cross-cultural development and validation of a patient self-administered questionnaire to assess quality of life in upper gastrointestinal disorders: The PAGI-QOL©

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Abstract

Summarize the Patient Assessment of Upper GastroIntestinal Disorders-Quality of Life (PAGI-QOL©) development and provide results on its reliability and validity from the international psychometric validation in dyspepsia, GastroEsophageal Reflux Disease (GERD), and gastroparesis. Methods: Subjects completed the pilot PAGI-QOL at baseline and 8 weeks; and a subsample also at 2 weeks. Other assessments were: Patient Assessment of Upper GastroIntestinal Disorders-Symptom Severity Index, SF-36, number of disability days. Results: 1736 patients completed the PAGI-QOL at baseline. The questionnaire was reduced, producing a 30-item final version covering five domains: Daily Activities, Clothing, Diet and Food Habits, Relationship (REL), and Psychological Well-Being and Distress. Internal consistency was excellent (Cronbach’s α range: 0.83–0.96). Test–retest reproducibility was good: intraclass correlations coefficients were over 0.70 except for the REL scale (0.61). Concurrent validity between the PAGI-QOL total score and all SF-36 subscale scores was good with moderate (0.52) to strong (0.72) correlations. PAGI-QOL scores showed excellent discriminant properties: patients who had spent some days in bed, had missed some days at work, and were kept from usual activities had much lower PAGI-QOL scores than those who did not (p < 0.0001). Conclusion: The PAGI-QOL is a valid and reliable instrument assessing quality of life in patients with dyspepsia, GERD, or gastroparesis.

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Abbreviations

CLO:

Clothing

DAC:

Daily Activities

DIE:

Diet

GERD:

Gastroesophageal Reflux Disease

GPs:

General Practitioners

ICC:

Intraclass Correlation Coefficients

MCS:

Mental Component Summary

PAGI:

Patient Assessment of Upper Gastrointestinal

PRO:

Patient Reported Outcomes

PCS:

Physical Component Summary

PSY:

Psychological

QoL:

Quality of Life

REL:

Relationship

UGID:

Upper Gastrointestinal Disorders

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Authors and Affiliations

  1. Mapi Values, Lyon, France

    Christine De la loge & Elyse Trudeau

  2. Mapi Values, Boston, MA, USA

    Patrick Marquis

  3. Division of Gastroenterology, Northwestern University, Chicago, IL, USA

    Peter Kahrilas

  4. Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy

    Vincenzo Stanghellini

  5. Department of Medicine, University of Sydney, Sydney, Australia

    Nicholas J. Talley

  6. Department of Gastroenterology, University of Leuven, Leuven, Belgium

    Jan Tack

  7. MEDTAP International, Inc., Bethesda, MD, USA

    Dennis A. Revicki

  8. MEDTAP International, Inc., Sindelfingen, Germany

    Anne M. Rentz

  9. Johnson & Johnson Pharmaceutical Services, LLC, Beerse, Belgium

    Dominique Dubois

Authors
  1. Christine De la loge
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  2. Elyse Trudeau
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  3. Patrick Marquis
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  4. Peter Kahrilas
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  5. Vincenzo Stanghellini
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  6. Nicholas J. Talley
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  7. Jan Tack
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  8. Dennis A. Revicki
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  9. Anne M. Rentz
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  10. Dominique Dubois
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Correspondence to Christine De la loge.

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De la loge, C., Trudeau, E., Marquis, P. et al. Cross-cultural development and validation of a patient self-administered questionnaire to assess quality of life in upper gastrointestinal disorders: The PAGI-QOL©. Qual Life Res 13, 1751–1762 (2004). https://doi.org/10.1007/s11136-004-8751-3

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  • DOI: https://doi.org/10.1007/s11136-004-8751-3

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