3-Phenoxybenzoic acid derivatives were synthesized. Their pharmacological activity was studied. Several compounds, in particular 2-cyanoprop-2-yl 3-phenoxybenzoate, were found to exhibit peroxisome proliferator-activated receptor γ agonist activity and to be capable of activating glucokinase and inhibiting protein glycation. The studied compounds did not influence dipeptidyl peptidase-4 activity.
Similar content being viewed by others
References
Yu. V. Popov, T. K. Korchagina, and V. S. Lobasenko, Synthesis, Reactions, and Applications [in Russian], VolgGTU, Volgograd (2015).
N. O. Saldabol, Ways to Synthesize and Develop Antitumor Drugs [in Russian], Collect. Sci. Works, Medgiz, Moscow (1962), p. 186.
M. D. Mashkovskii, Drugs [in Russian], Vol. 1 – 2, Novaya Volna, Moscow (2001).
W. Yang, C. Rachez, L. P. Freedman, et al., Mol. Cell. Biol., 20(21), 8008 – 8017 (2000).
D. Salt, Sigma Quality Control Test Procedure Enzymatic Assay of Glucokinase (EC 2.7.1.2) Principle, pp. 7 – 10.
T. Ohishi and S. Yoshida, Expert Opin. Invest. Drugs, 21(3), 321 – 328 (2012).
V. Matheeussen, A.-M. Lambeir, W. Jungraithmayr, et al., Clin. Chim. Acta, 413(3 – 4), 456 – 462 (2012).
F. X. Pi-Sunyer, A. Schweizer, D. Mills, et al., Diabetes Res. Clin. Pract., 76(1), 132 – 138 (2007).
A. Jedsadayanmata, Naresuan Univ. J., 13(2), 35 – 41 (2005).
Acknowledgments
The research was sponsored by a Russian Science Foundation Grant (Project No. 14-25-00139).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 3, pp. 20 – 26, March, 2020.
Rights and permissions
About this article
Cite this article
Spasov, A.A., Lobasenko, V.S., Kosolapov, V.A. et al. Synthesis and Pharmacological Activity of 3-Phenoxybenzoic Acid Derivatives. Pharm Chem J 54, 229–235 (2020). https://doi.org/10.1007/s11094-020-02185-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-020-02185-z