Electronic retinal implants represent a promising technology for partial restoration of vision in severe neurodegenerative diseases. The underlying concept is that they replace damaged photoreceptors with electronic devices able to convert light signals into electrical impulses which stimulate bipolar or retinal ganglion cells. This review examines the history of the creation of this technology and the current state of progress in this area, as well as various design options and the principles of operation of retinal implants.
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Arens-Arad, T., Farah, N., Lender, R., et al., “Cortical interactions between prosthetic and natural vision,” Curr. Biol., 30, No. 1, 176–182 e172 (2020), https://doi.org/10.1016/j.cub.2019.11.028.
Asghar, S. A., Pal, P., Nazeer, K., and Mahadevappa, M., “A computational study of graphene as a prospective material for microelectrodes in retinal prosthesis and electric crosstalk analysis,” in: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual International Conference 2020 (2020), pp. 2291–2294, https://doi.org/https://doi.org/10.1109/EMBC44109.2020.9176388.
Caspi, A., Barry, M. P., Patel, U. K., et al., “Eye movements and the perceived location of phosphenes generated by intracranial primary visual cortex stimulation in the blind,” Brain Stimul., 14, No. 4, 851–860 (2021), https://doi.org/https://doi.org/10.1016/j.brs.2021.04.019.
Caspi, A., Dorn, J. D., McClure, K. H., et al., “Feasibility study of a retinal prosthesis: spatial vision with a 16-electrode implant,” Arch. Ophthalmol., 127, No. 4, 398–401 (2009), https://doi.org/https://doi.org/10.1001/archophthalmol.2009.20.
Choi, C., Choi, M. K., Liu, S., et al., “Human eye-inspired soft optoelectronic device using high-density MoS(2)-graphene curved image sensor array,” Nat. Commun., 8, No. 1, 1664 (2017), https://doi.org/10.1038/s41467-017-01824-6.
Chow, A. Y., Chow, V. Y., Packo, K. H., et al., “The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa,” Arch. Ophthalmol., 122, No. 4, 460–469 (2004), https://doi.org/https://doi.org/10.1001/archopht.122.4.460.
da Cruz, L., Dorn, J. D., Humayun, M. S., et al., “Five-year safety and performance results from the Argus II Retinal Prosthesis System Clinical Trial,” Ophthalmology, 123, No. 10, 2248–2254 (2016), https://doi.org/https://doi.org/10.1016/j.ophtha.2016.06.049.
Daschner, R., Greppmaier, U., Kokelmann, M., et al., “Laboratory and clinical reliability of conformally coated subretinal implants,” Biomed. Microdev., 19, No. 1, 7 (2017), https://doi.org/10.1007/s10544-017-0147-6.
Daschner, R., Rothermel, A., Rudorf, R., et al., “Functionality and performance of the subretinal implant chip alpha AMS,” Sensors Mater., 30, No. 2, SI, 179–192 (2018), https://doi.org/10.18494/SAM.2018.1726.
De Silva, S. R. and Moore, A. T., “Optogenetic approaches to therapy for inherited retinal degenerations,” J. Physiol., 600, No. 21, 4623–4632 (2022), https://doi.org/https://doi.org/10.1113/JP282076.
Demchinsky, A. M., Shaimov, T. B., Goranskaya, D. N., et al., “The first deaf-blind patient in Russia with Argus II retinal prosthesis system: what he sees and why,” J. Neural Eng., 16, No. 2, 025002 (2019), https://doi.org/10.1088/1741-2552/aafc76.
Edwards, T. L., Cottriall, C. L., Xue, K., et al., “Assessment of the electronic retinal implant Alpha AMS in restoring vision to blind patients with end-stage retinitis pigmentosa,” Ophthalmology, 125, No. 3, 432–443 (2018), https://doi.org/https://doi.org/10.1016/j.ophtha.2017.09.019.
Eickenscheidt, M., Herrmann, T., Weisshap, M., et al., “An optoelectronic neural interface approach for precise superposition of optical and electrical stimulation in flexible array structures,” Biosens. Bioelectron., 205, 114090 (2022), https://doi.org/https://doi.org/10.1016/j.bios.2022.114090.
Feldman, T., Dontsov, A., Yakovleva, M., and Ostrovsky, M. A., “Photobiology of lipofuscin granules in the retinal pigment epithelium cells of the eye: norm, pathology, age,” Biophys. Rev., 14, No. 4, 1051–1065 (2022), https://doi.org/https://doi.org/10.1007/s12551-022-00989-9.
Firsov, M. L., “ Perspectives for optogenetic prosthetization of the retina,” Zh. Vyssh. Nerv. Deyat., 67, No. 5, 53–62 (2017).
Ghani, N., Bansal, J., Naidu, A., and Chaudhary, K. M., “Long term positional stability of the Argus II retinal prosthesis epiretinal implant,” BMC Ophthalmol., 23, No. 1, 70 (2023), https://doi.org/10.1186/s12886-022-02736-w.
Goetz, G. A. and Palanker, D. V., “Electronic approaches to restoration of sight,” Rep. Progr., 79, No. 9, 096701 (2016), https://doi.org/10.1088/0034-4885/79/9/096701.
Hornig, R., Zehnder, T., Velikay-Parel, M., et al., “The IMI retinal implant system,” in: Artificial Sight: Basic Research, Biomedical Engineering, and Clinical Advances (2007), pp. 111–128, https://doi.org/10.1007/978-0-387-49331-2_6.
Humayun, M. S., de Juan, E., Jr., Weiland, J. D., et al., “Pattern electrical stimulation of the human retina,” Vision Res., 39, No. 15, 2569–2576 (1999), https://doi.org/https://doi.org/10.1016/s0042-6989(99)00052-8.
Humayun, M. S., Weiland, J. D., Fujii, G. Y., et al., “Visual perception in a blind subject with a chronic microelectronic retinal prosthesis,” Vision Res., 43, No. 24, 2573–2581 (2003), https://doi.org/https://doi.org/10.1016/s0042-6989(03)00457-7.
Jiang L, Lu, G., Zeng, Y., Sun, Y., et al., “Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses,” Nat. Commun., 13, No. 1, 3853 (2022), https://doi.org/10.1038/s41467-022-31599-4.
Jones, B. W., Kondo, M., Terasaki, H., et al., “Retinal remodeling,” Jpn. J. Ophthalmol., 56, No. 4, 289–306 (2012), https://doi.org/https://doi.org/10.1007/s10384-012-0147-2.
Kleinlogel, S., Vogl, C., Jeschke, M., et al., “Emerging approaches for restoration of hearing and vision,” Physiol. Rev., 100, No. 4, 1467–1525 (2020), https://doi.org/https://doi.org/10.1152/physrev.00035.2019.
Lorach, H. and Palanker, D., “High resolution photovoltaic subretinal prosthesis for restoration of sight,” in: Artificial Vision: A Clinical Guide (2017), pp. 115–124, https://doi.org/10.1007/978-3-319-41876-6_9.
Luo, Y. H. and da Cruz, L., “The Argus((R)) II retinal prosthesis system,” Prog. Retin. Eye Res., 50, 89–107 (2016), https://doi.org/https://doi.org/10.1016/j.preteyeres.2015.09.003.
Luo, Y. H., Fukushige, E., and Da Cruz, L., “The potential of the second sight system bionic eye implant for partial sight restoration,” Expert Rev. Med. Devices, 13, No. 7, 673–681 (2016), https://doi.org/https://doi.org/10.1080/17434440.2016.1195257.
Martinez-Fernandez de la Camara, C., Cehajic-Kapetanovic, J., and MacLaren, R. E., “Emerging gene therapy products for RPGR-associated X-linked retinitis pigmentosa,” Expert Opin. Emerg. Drugs, 27, No. 4, 431–443 (2022), https://doi.org/10.1080/14728214.2022.2152003.
Montezuma, S. R., Sun, S. Y., Roy, A., et al., “Improved localisation and discrimination of heat emitting household objects with the artificial vision therapy system by integration with thermal sensor,” Brit. J. Ophthalmol., 104, No. 12, 1730–1734 (2020), https://doi.org/https://doi.org/10.1136/bjophthalmol-2019-315513.
Muqit, M. K., Velikay-Parel, M., Weber, M., et al., “Six-month safety and efficacy of the intelligent retinal implant System II Device in retinitis pigmentosa,” Ophthalmology, 126, No. 4, 637–639 (2019), https://doi.org/https://doi.org/10.1016/j.ophtha.2018.11.010.
Newton, F. and Megaw, R., “Mechanisms of photoreceptor death in retinitis pigmentosa,” Genes (Basel), 11, No. 10, 1120 (2020), https://doi.org/https://doi.org/10.3390/genes11101120.
Ostrovskii, M. A. and Kirpichnikov, M. P., “Perspectives for optogenetic prosthetization of the degenerative retina,” Biokhimiya, 84, No. 5, 634–647 (2019).
Palanker, D., Le Mer, Y., Mohand-Said, S., and Sahel, J. A., “Simultaneous perception of prosthetic and natural vision in AMD patients,” Nat. Commun., 13, No. 1, 513 (2022), https://doi.org/10.1038/s41467-022-28125-x.
Palanker, D., Le Mer, Y., Mohand-Said, S., et al., “Photovoltaic restoration of central vision in atrophic age-related macular degeneration,” Ophthalmology, 127, No. 8, 1097–1104 (2020), https://doi.org/https://doi.org/10.1016/j.ophtha.2020.02.024.
Peterman, M. C., Mehenti, N. Z., Bilbao, K. V., et al., “The Artificial Synapse Chip: a flexible retinal interface based on directed retinal cell growth and neurotransmitter stimulation,” Artif. Organs, 27, No. 11, 975–985 (2003), https://doi.org/https://doi.org/10.1046/j.1525-1594.2003.07307.x.
Pfeiffer, R. L., Marc, R. E., and Jones, B. W., “Persistent remodeling and neurodegeneration in late-stage retinal degeneration,” Prog. Retin. Eye Res., 74, 100771 (2020), https://doi.org/https://doi.org/10.1016/j.preteyeres. 2019.07.004.
Piri, N., Grodsky, J. D., and Kaplan, H. J., “Gene therapy for retinitis pigmentosa,” Taiwan J. Ophthalmol., 11, No. 4, 348–351 (2021), https://doi.org/https://doi.org/10.4103/tjo.tjo_47_21.
Rachitskaya, A. V., DeBenedictis, M., and Yuan, A., “What happened to retinal prostheses?” Retina, 49, No. 5, 803–804 (2020).
Schaffrath, K., Lohmann, T., Seifert, J., et al., “New epiretinal implant with integrated sensor chips for optical capturing shows a good biocompatibility profile in vitro and in vivo,” Biomed. Eng. Online, 20, No. 1, 102 (2021), https://doi.org/10.1186/s12938-021-00938-9.
Shire, D. B., Gingerich, M. D., Wong, P. I., et al., “Micro-fabrication of components for a high-density sub-retinal visual prosthesis,” Micromachines (Basel), 11, No. 10, 944 (2020), https://doi.org/https://doi.org/10.3390/mi11100944.
Song, D. J., Bao, X. L., Fan, B., and Li, G. Y., “Mechanism of cone degeneration in retinitis pigmentosa,” Cell. Mol. Neurobiol., 43, No. 3, 1037–1048 (2023), https://doi.org/https://doi.org/10.1007/s10571-022-01243-2.
Stanga, P. E., Tsamis, E., Siso-Fuertes I, et al., “Electronic retinal prosthesis for severe loss of vision in geographic atrophy in age-related macular degeneration: First-in-human use,” Eur. J. Ophthalmol., 31, No. 3, 920–931 (2021), https://doi.org/https://doi.org/10.1177/11206721211000680.
Stiles, N. B., Patel, V. R., and Weiland, J. D., “Multisensory perception in Argus II retinal prosthesis patients: Leveraging auditory-visual map**s to enhance prosthesis outcomes,” Vision Res., 182, 58–68 (2021), https://doi.org/https://doi.org/10.1016/j.visres.2021.01.008.
Stingl, K., Bartz-Schmidt, K. U., Besch, D., et al., “Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS,” Proc. Roy. Soc. B Biol. Sci., 280, No. 1757, 20130077 (2013), https://doi.org/10.1098/rspb.2013.0077.
Stingl, K., Bartz-Schmidt, K. U., Besch, D., et al., “Subretinal visual implant Alpha IMS – clinical trial interim report,” Vision Res., 111, Pt. B, 149–160 (2015), https://doi.org/10.1016/j.visres.2015.03.001.
Thomas, C. J., Mirza, R. G., and Gill, M. K., “Age-related macular degeneration,” Med. Clin., 105, No. 3, 473–491 (2021), https://doi.org/https://doi.org/10.1016/j.mcna.2021.01.003.
Wang, B. Y., Chen, Z. C., Bhuckory, M., et al., “Electronic photoreceptors enable prosthetic visual acuity matching the natural resolution in rats,” Nat. Commun., 13, No. 1, 6627 (2022), https://doi.org/10.1038/s41467-022-34353-y.
Werginz, P., Wang, B. Y., Chen, Z. C., and Palanker, D., “On optimal coupling of the ‘electronic photoreceptors’ into the degenerate retina,” J. Neural Eng., 17, No. 4, 045008 (2020), https://doi.org/10.1088/1741-2552/aba0d2.
Wu, K. Y., Kulbay, M., Toameh, D., et al., “Retinitis pigmentosa: Novel therapeutic targets and drug development,” Pharmaceutics, 15, No. 2, 685 (2023), https://doi.org/;https://doi.org/10.3390/pharmaceutics15020685.
Yu, Z. H., Chen, W. J., Liu, X., et al., “Folate-modified photoelectric responsive polymer microarray as bionic artificial retina to restore visual function,” ACS Appl. Mater. Interfaces, 12, No. 25, 28759–28767 (2020), https://doi.org/https://doi.org/10.1021/acsami.0c04058.
Yue, L., Castillo, J., Gonzalez, A. C., et al., “Restoring color perception to the blind: An electrical stimulation strategy of retina in patients with end-stage retinitis pigmentosa,” Ophthalmology, 128, No. 3, 453–462 (2021), https://doi.org/https://doi.org/10.1016/j.ophtha.2020.08.019.
Zhou, D. D., Dorn, J. D., and Greenberg, R. J., “The Argus® II retinal prosthesis system: An overview,” in: 2013 IEEE Int. Conference on Multimedia and Expo Workshops (ICMEW) (2013), pp. 1–6, https://doi.org/https://doi.org/10.1109/ICMEW.2013.6618428.
Zrenner, E., Bartz-Schmidt, K. U., Benav, H., et al., “Subretinal electronic chips allow blind patients to read letters and combine them to words,” Proc. Roy. Soc. B Biol. Sci., 278, No. 1711, 1489–1497 (2011).
Zrenner, E., Miliczek, K. D., Gabel, V. P., et al., “The development of subretinal microphotodiodes for replacement of degenerated photoreceptors,” Ophthalmic Res., 29, No. 5, 269–280 (1997), https://doi.org/https://doi.org/10.1159/000268025.
Zrenner, E., Stett, A., Weiss, S., et al., “Can subretinal microphotodiodes successfully replace degenerated photoreceptors?” Vision Res., 39, No. 15, 2555–2567 (1999), https://doi.org/https://doi.org/10.1016/s0042-6989(98)00312-5.
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Translated from Sensornye Sistemy, Vol. 37, No. 3, pp. 205–217, October–December, 2023
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Firsov, M.L. Electronic Visual Prostheses. Neurosci Behav Physi 54, 293–300 (2024). https://doi.org/10.1007/s11055-024-01597-8
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DOI: https://doi.org/10.1007/s11055-024-01597-8