Abstract
Background
Our previous study has reported that interleukin-16 (IL-16) genetic polymorphisms are significantly related to chronic hepatitis B (CHB) and hepatitis B virus-related (HBV-related) hepatocellular carcinoma (HCC). As CHB, liver cirrhosis (LC), and HCC are development processes, this study aimed to determine genetic correlation of IL-16 polymorphisms with HBV-related LC in a Chinese population.
Methods
IL-16 gene rs11556218, rs4072111, and rs4778889 polymorphism in 129 patients with HBV-related LC and 168 healthy individuals were genotyped via polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). PCR–RFLP results were verified by DNA sequencing.
Results
The allelic and genotypic distributions of IL-16 rs11556218, rs4072111, and rs4778889 polymorphisms in HBV-related LC patients showed no significant difference from those in healthy controls. Furthermore, no relationship was observed between the haplotype distribution and susceptibility to HBV-related LC.
Conclusions
This work provided the first evidence that the IL-16 genetic polymorphisms may not be associated with HBV-related LC risk.
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Data availability
The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by XZ and WT. The first draft of the manuscript was written by XZ and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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This study was approved by the Ethics Committee of the First Affiliated Hospital of Guangxi Medical University. All subjects included in this study previously provided informed consent.
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Shan Li and Dong Liang are corresponding authors.
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Zhang, X., Tang, W., Qin, X. et al. Interleukin-16 genetic polymorphisms in Guangxi Chinese with hepatitis B virus-related liver cirrhosis. Mol Biol Rep 50, 5247–5254 (2023). https://doi.org/10.1007/s11033-023-08450-0
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DOI: https://doi.org/10.1007/s11033-023-08450-0