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Green synthesis and investigation of antioxidant and antibacterial activity of new derivatives of chromenoazepines employing CuO/TiO2@MWCNTs

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Abstract

The synthesis of novel, high-yield derivatives of chromenoazepine was investigated in this work. CuO/TiO2@MWCNTs was used as a nanocatalyst in a multicomponent reaction involving 4-aminocumarine, activated acetylenic chemicals, and alkyl bromide in room temperature water to create these novel compounds. Using MCRs of 4-aminocumarine, isothiocyanate, and alkyl bromide in the presence of CuO/TiO2@MWCNTs as nanocatalysts in room-temperature water, chromenothiazepines were synthesized under comparable conditions. The freshly synthesized azepine exhibits antioxidant activity since its NH group has undergone two evaluation processes. Additionally, using two types of Gram-negative bacteria in a disk distribution procedure, the antibacterial activity of recently developed azepines was evaluated, and these compounds also inhibited the growth of Gram-positive bacteria. This method’s benefits include quick reaction times, large product yields, and straightforward catalyst and product separation through easy steps.

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The data that support the findings of this study are available in the supplementary material of this article.

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Acknowledgements

The author sincerely would like to acknowledge the Islamic Azad University of Ardabil for its support.

Author information

Authors and Affiliations

  1. Department of Chemistry, Ardabil Branch, Islamic Azad University, Ardabil, Iran

    Leila Hasani & Elham Ezzatzadeh

  2. Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran

    Zinatossadat Hossaini

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  1. Leila Hasani
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  2. Elham Ezzatzadeh
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  3. Zinatossadat Hossaini
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Correspondence to Elham Ezzatzadeh.

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Hasani, L., Ezzatzadeh, E. & Hossaini, Z. Green synthesis and investigation of antioxidant and antibacterial activity of new derivatives of chromenoazepines employing CuO/TiO2@MWCNTs. Mol Divers (2024). https://doi.org/10.1007/s11030-023-10803-7

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  • DOI: https://doi.org/10.1007/s11030-023-10803-7

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