Abstract
This study aimed at assessing the elemental composition of dietary supplements mostly consumed by physically active individuals in Belo Horizonte. Neutron activation analysis, k 0-standardization method, analysing large samples, was applied. The presence of impurities not considered essential for human beings and potentially toxic elements pointed out the risk of long-term consumption. The results were compared to values foreseen in the Brazilian legislation, and to the ones described in the products labels and directions. This preliminary assessment suggests the need to improve the quality control of raw material used in dietary supplements.
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Blendon RJ, DesRoches CM, Benson JN, Brodie M, Altman DE (2001) Americans’ views on the use and regulation of dietary supplements. Arch Intern Med 161:805–810
Marra MV, Boyar AP (2009) Position of the American dietetic association: nutrient supplementation. J Am Diet Assoc 109:2073–2085
ASBRAN, Brazilian Nutrition Association (2014). http://www.asbran.org.br/noticias.php?dsid=1139. Accessed 23 Aug 2016
ANVISA, Brazilian Health Surveillance Agency (1998). http://www.anvisa.gov.br. Accessed 30 Jul 2016
Scofield DE, Unruh S (2006) Dietary supplement use among adolescent athletes in central Nebraska and their sources of information. J Strength Cond Res 20:452–455
American College of Sports Medicine, American Dietetic Association (2000) Joint position statement: nutrition and athletic performance. American College of Sports Medicine, American Dietetic Association, and Dietitians of Canada. Med Sci Sports Exerc 32:2130–2145
Goston JL, Correia MITD (2010) Intake of nutritional supplements among people exercising in gyms and influencing factors. Nutrition 26:604–611
Calfee R, Fadale P (2006) Popular ergogenic drugs and supplements in young athletes. Pediatrics 117:e577–e589
Petróczi A, Naughton DP, Mazanov J, Holloway A, Bingham J (2007) Limited agreement exists between rationale and practice in athletes’ supplement use for maintenance of health: a retrospective study. Nutr J 6:34
Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, Kessler RC (1998) Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA 280:1569–1575
Silva LFM, Ferreira KS (2014) Food safety of supplements sold in Brazil. Rev Bras Med Esporte 20:374–378
Dolan SP, Nortrup DA, Bolger PM, Capar SG (2003) Analysis of dietary supplements for arsenic, cadmium, mercury, and lead using inductively coupled plasma mass spectrometry. J Agric Food Chem 51:1307–1312
CDC, Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey (2016). http://www.cdc.gov/nchs/nhanes. Accessed 10 Feb 2016
Rockwell MS, Nickols-Richardson SM, Thye FW (2001) Nutrition knowledge, opinions, and practices of coaches and athletic trainers at a division I university. Int J Sport Nutr Exerc Metab 11:174–185
Raman P, Patino LC, Nair MG (2004) Evaluation of metal and microbial contamination in botanical supplements. J Agric Food Chem 52:7822–7827
Haymes EM (1991) Vitamin and mineral supplementation to athletes. Int J Sport Nutr 1:146–169
WHO, World Health Organization (1996) Trace elements in human nutrition and health. WHO, Geneva
Chan K (2003) Some aspects of toxic contaminants in herbal medicines. Chemosphere 52:1361–1371
Leal AS, Menezes MABC, Rodrigues RR, Andonie O, Vermaercke P, Sneyeres L (2008) A comparative neutron activation analysis study of common generic manipulated and reference medicines commercialized in Brazil. Appl Radiat Isot 66:1307–1312
Silveira JN, Menezes MABC, Lara PCP, Beinner MA, Silva JBB (2015) Determination of Al, Ca, Cl, Cr, K, Mg, Sb and Ti in industrialized and formulated antihypertensive drugs using neutron activation analysis. J Pharm Biol Sci 10:40–45
Abernethy DR, DeStefano AJ, Cecil TL, Zaidi K, Williams RL, Panel UMIA (2010) Metal impurities in food and drugs. Pharmaceut Res 27:750–755
Salles PMB, Menezes MABC, Jaćimović R, Campos TPR (2016) Inorganic elements in sugar samples consumed in several countries. J Radioanal Nucl Chem 308:485–493
Leblebici J, Volkan M (1998) Sample preparation for arsenic, copper, iron, and lead determination in sugar. J Agric Food Chem 46:173–177
Souza MG, Vieira EC, Oliveira PV (2009) Determinação de As, Cd e Pb em amêndoas e mesocarpo de babaçu, sapucaia, xixá e castanha-do-pará por espectrometria de absorção atômica. Quím Nova 32:1442–1446
Waheed S, Rahman S, Gill KP (2009) INAA and AAS of different products from sugar cane industry in Pakistan: toxic trace elements for nutritional safety. J Radioanal Nucl Chem 279:725–731
Avula B, Wang YH, Smillie TJ, Duzgoren-Aydin NS, Khan IA (2010) Quantitative determination of multiple elements in botanicals and dietary supplements using ICP-MS. J Agric Food Chem 58:8887–8894
Kim W, Lee K (2013) Lead and cadmium in functional health foods and Korean herbal medicines. Food Addit Contam Part B 6(2):146–149
Potocnik D, Necemer M, Mazej D, Jacimovic R, Ogrinc N (2016) Multi-elemental composition of Slovenian milk: analytical approach and geographical origin determination. Acta Imeko 5:15–21
Greenberg RR, Bode P, De Nadai EA (2011) Neutron activation analysis: a primary method of measurement. Spectrochim Acta Part B 66:193–241
Menezes MABC, Sabino CVS, Amaral A, Maia E (2000) k 0-NAA applied to certified reference materials and hair samples: evaluation of exposure level in a galvanising industry. J Radioanal Nucl Chem 245:173–178
Menezes MABC, Sabino CVS, Franco MB, Maia ECP, Albinati CCB (2004) Assessment of workers’ contamination caused by air pollution exposure in industry using biomonitors. J Atmos Chem 49:403–414
Menezes MABC, Maia E, Albinati C, Sabino CVS, Batista J (2004) How suitable are scalp hair and toenail as biomonitors? J Radioanal Nucl Chem 259:81–86
Menezes MABC, Maia E, Albinati C, Amaral A (2007) Assessment of gold exposure and contamination in galvanizing workplace by neutron activation analysis. J Radioanal Nucl Chem 271:119–123
Menezes MABC, Jaćimović R (2014) Implementation of a methodology to analyse cylindrical 5-g sample by neutron activation technique, k 0 method, at CDTN/CNEN, Belo Horizonte. Brazil. J Radioanal Nucl Chem 300:523–531
Domingues SF, Marins JCB (2007) Ergogenic aids and nutritional supplement use among resistance training practitioner in Belo Horizonte. Fit Perform J 6:218–226
Alves C, Lima RVB (2009) Dietary supplement use by adolescents. J Pediatr 85:287–294
Kreider RB (1999) Dietary supplements and the promotion of muscle growth with resistance exercise. Sport Med 27:97–110
Peralta J, Amancio OMS (2002) A creatina como suplemento ergogênico para atletas. Rev Nutr 15:83–93
Betts J, Williams C, Duffy K, Gunner F (2007) The influence of carbohydrate and protein ingestion during recovery from prolonged exercise on subsequent endurance performance. J Sports Sci 25:1449–1460
Lukaski HC (2000) Magnesium, zinc, and chromium nutriture and physical activity. Am J Clin Nutr 72:585S–593S
Maughan RJ (1999) Role of micronutrients in sport and physical activity. Br Med Bull 55:683–690
Haraguchi FK, De Abreu WC, De Paula H (2006) Proteínas do soro do leite: composição, propriedades nutricionais, aplicações no esporte e benefícios para a saúde humana. Rev Nutr 19:479–488
Børsheim E, Tipton KD, Wolf SE, Wolfe RR (2002) Essential amino acids and muscle protein recovery from resistance exercise. Am J Physiol Endocrinol Metab 283:E648–E657
IAEA, International Atomic Energy Agency (2000) Certified reference material IAEA-SOIL-7. IAEA, Vienna
NRCRM, National Research Centre for CRM (1987) Institute of Geophysical and Geochemical Exploration components. Langfang, China: (GBW 0805), Tea Leaves
Statistical methods for use in proficiency testing by interlaboratory comparisons. ISO, Geneve, Switzerland. ISO 13528: 2005
De Corte F, Simonits A (1994) Vade Mecum for k 0 Users. DMS Research, Geleen
Kayzero for Windows (2011), User’s manual, for reactor neutron activation analysis (NAA) using the k 0 standardisation method, Ver. 2.42. k 0-ware, Heerlen
Menezes MABC, Jaćimović R (2006) Optimised k 0-instrumental neutron activation method using the TRIGA MARK I IPR-R1 reactor at CDTN/CNEN, Belo Horizonte, Brazil. Nucl Instrum Methods Phys Res A 564:707–715
Menezes MÂBC, Jaćimović R (2011) k 0-INAA quality assessment by analysis of soil reference material GBW07401 using the comparator and neutron flux monitor approaches. Appl Radiat Isot 69:1057–1063
Simonits A, Ostor J, Kalvin S, Fazekas B (2003) HyperLab: a new concept in gamma-ray spectrum analysis. J Radioanal Nucl Chem 257:589–595
HyperLab (2009) Gamma spectroscopy software, HyperLabs Software, Budapest, Hungary, 1998–2013. http://hlabsoft.com. Accessed 9 Jun 2011
CNEN, Brazilian Commission for Nuclear Energy (2011) http://cnen.gov.br Accessed 12 Jul 2016
ANVISA, Brazilian Health Surveillance Agency (2013). http://www.anvisa.gov.br. Accessed 13 Jan 2016
Bohr DF, Brodie DC, Cheu DH (1958) Effect of electrolytes on arterial muscle contraction. Circulation 17:746–749
McDonough AA (2010) Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure. Am J Physiol Regul Integr Comp Physiol 298:R851–R861
Brown IJ, Tzoulaki I, Candeias V, Elliott P (2009) Salt intakes around the world: implications for public health. Int J Epidemiol 38:791–813
Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O’Keefe JH, Brand-Miller J (2005) Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr 81:341–354
Liem DG, Miremadi F, Keast R (2011) Reducing sodium in foods: the effect on flavor. Nutrients 3:694–711
Webster JL, Dunford EK, Hawkes C, Neal BC (2011) Salt reduction initiatives around the world. J Hypertens 29:1043–1050
Chasapis CT, Loutsidou AC, Spiliopoulou CA, Stefanidou ME (2012) Zinc and human health: an update. Arch Toxicol 86:521–534
Brown MA, Thom JV, Orth GL, Cova P, Juarez J (1964) Food poisoning involving zinc contamination. Arch Environ Occup Health 8:657–660
Rizk SL, Sky-Peck HH (1984) Comparison between concentrations of trace elements in normal and neoplastic human breast tissue. Cancer Res 44:5390–5394
Diez M, Cerdà FJ, Arroyo M, Balibrea JL (1989) Use of the copper/zinc ratio in the diagnosis of lung cancer. Cancer 63:726–730
ANVISA, Brazilian Health Surveillance Agency (1965). http://www.anvisa.gov.br. Accessed 13 Jan 2016
ANVISA, Brazilian Health Surveillance Agency (1998a). http://www.anvisa.gov.br. Accessed 13 Jan 2016
Acknowledgements
The authors thank CAPES, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Coordination for the Improvement of Higher Education Personnel), CNPq, Conselho Nacional de Desenvolvimento Científico e Tecnológico, (National Counsel of Technological and Scientific Development) and Nuclear Technology Development Centre, Brazilian Commission for Nuclear Energy, CDTN/CNEN for their financial support for this research project.
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de Salles, P.M.B., de Barros Correia Menezes, M., Sathler, M.M. et al. Elemental composition of dietary supplements most consumed in Belo Horizonte, Brazil, analysed by k 0-INAA. J Radioanal Nucl Chem 312, 421–431 (2017). https://doi.org/10.1007/s10967-017-5222-1
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DOI: https://doi.org/10.1007/s10967-017-5222-1