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Microvascularity, blood flow and tissue structure at the subchondral plate using an X-ray fluorescence technique

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Abstract

The measurement of blood flow and blood in bone and cartilaginous tissues is crucial to understanding of the development of various diseases, but it presents a formidable technical challenge. We have therefore developed a method based on the detection of metallized microspheres using X-ray fluorescence. This approach provides unrivalled sensitivity and spatial resolution and also allows us simultaneously to measure other markers of the metabolic status of the tissue.

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Authors and Affiliations

  1. Biomedical Physics Group, School of Physics, University of Exeter, Exeter, UK

    P. Muthuvelu, R. E. Ellis, E. M. Green, D. Attenburrow, K. Arkill, D. B. Colridge, C. P. Winlove & D. A. Bradley

  2. ESRF, BP 220, F-38043, Grenoble Cedex, France

    R. Barrett

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  1. P. Muthuvelu
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  2. R. E. Ellis
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  3. E. M. Green
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  4. D. Attenburrow
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  5. R. Barrett
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  6. K. Arkill
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  7. D. B. Colridge
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  8. C. P. Winlove
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  9. D. A. Bradley
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Muthuvelu, P., Ellis, R.E., Green, E.M. et al. Microvascularity, blood flow and tissue structure at the subchondral plate using an X-ray fluorescence technique. J Radioanal Nucl Chem 271, 771–775 (2007). https://doi.org/10.1007/s10967-007-0340-9

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  • DOI: https://doi.org/10.1007/s10967-007-0340-9

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