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Green synthesized AgNPs using Clitoria ternatea extract and its confinement on SBA-15/GPTMS-TAEA for controlled drug release of ciprofloxacin

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Abstract

Ag nanoparticles (Ag NPs) were synthesized using Clitoria ternatea plant extract and confined onto mesoporous SBA-15, functionalized with 3-glycidoxypropyl trimethoxysilane followed by tris (2-amino ethyl) amine (SBA-15/GPTMS-TAEA). The sequential grafting of TAEA, GPTMS, and confinement of Ag NPs on the mesoporous SBA-15 was verified by various spectroscopic and microscopic techniques such as FT-IR, SEM, TEM-EDX, XRD, SAXRD, BET, TGA, 29Si NMR, and 13C MAS NMR analysis. HR-TEM analysis revealed that the mean diameter of green synthesized Ag NPs is 6–8 nm and the successful confinement of Ag NPs inside the pores of SBA-15/GPTMS-TAEA. The synthesized SBA-15/GPTMS-TAEA-Ag was used are a carrier for binding ciprofloxacin and the controlled drug release of ciprofloxacin was monitored on a UV–Vis spectrophotometer. In Vitro, the loading and release of Ciprofloxacin were found to be 19.8% and 98.14% of the loaded Ciprofloxacin. The kinetic models deducted from the release study demonstrated that SBA-15/GPTMS-TAEA-Ag is a potential carrier for the controlled release of Ciprofloxacin.

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Acknowledgements

We thank CoE-AMGT (MHRD, New Delhi) center for the instrumental facility. We acknowledge Amrita Center for Nanosciences and Molecular Medicine (ACNSMM), AIMS Kochi for recording XPS and TEM images.

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Authors and Affiliations

  1. Department of Sciences, Amrita School of Physical Sciences, Amrita Vishwa Vidyapeetham, Coimbatore, India

    B. Shree Haripriya, D. R. Anakha & R. Yamuna

  2. Bio-Materials Chemistry Research Laboratory, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore, India

    B. Shree Haripriya, D. R. Anakha & R. Yamuna

  3. Petroleum Research Center, Kuwait Institute for Scientific Research, Al Ahmadi, Kuwait

    Mari Vinoba

  4. Department of Chemistry, Central University of Kerala, Periye, Kerala, 671316, India

    Margandan Bhagiyalakshmi

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Contributions

SHP contributed to the material synthesis, design of experiments, formal analysis, data analysis, writing the original manuscript and ADR contributed to the investigation, data analysis, writing the manuscript. MV contributed to the formal analysis, RY and MB contributed to the conceptualization, supervision, validation, reviewing and editing. The final manuscript was revised and approved by all authors.

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Correspondence to R. Yamuna or Margandan Bhagiyalakshmi.

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10934_2023_1515_MOESM1_ESM.doc

Instrumentation details, the SAED images of Ag NPs, and SBA-15/GPTMS-TAEA-Ag nanocomposites, drug release kinetics table and UV–Vis spectra are given in the supporting material. Supplementary material 1 (DOC 3442.0 kb)

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Shree Haripriya, B., Anakha, D.R., Yamuna, R. et al. Green synthesized AgNPs using Clitoria ternatea extract and its confinement on SBA-15/GPTMS-TAEA for controlled drug release of ciprofloxacin. J Porous Mater 31, 351–363 (2024). https://doi.org/10.1007/s10934-023-01515-2

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