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A Handy Chemical Sensor Based on Benzaldehyde and Imidazo[1,2-a]pyridine Mixture for Naked-eye Colorimetric and Fluorescent Detection of F−

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Abstract

Upon the Schiff base condensation reaction of imidazo[1,2-a]pyridine-2-carbohydrazide and 2,5-dihydroxybenzaldehyde, a bimodal colorimetric and fluorescent chemosensor 1o for assaying fluoride (F−) in DMSO was synthesized. The characterization of 1o structure was obtained by 1H NMR, 13C NMR and MS.The structure of 1o was characterized by 1H NMR, 13C NMR and MS. Under the presence of various anions, 1o could be applied for naked-eye and fluorescent detection of F− (naked eye: colorless to yellow; fluorescence: dark to green) and displayed promising performance, such as high selectivity and sensitivity, as well as a low detection limit. Upon calculation, the detection limit of chemosensor 1o for F− was 193.5 nM, which is well below the allowed maximum value of F− (1.5 mg/L) by WHO. As the intermolecular proton transfer mechanism induced "turn-on" fluorescent signal and naked-eye color change of F− to 1o through deprotonation effect, which was confirmed by Job's plot curve, mass spectrometry and 1H NMR titration. Alternatively, the chemosensor 1o can be effectively manufactured into test strips to detect fluoride in solid state, which is user-friendly with no additional equipment required.

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Acknowledgements

The authors are grateful for financial support from the National Natural Science Foundation of China (41867053), the project of the Science Funds of Jiangxi Education Office (GJJ190597).

Funding

This work was supported by the National Natural Science Foundation of China (41867052) and the project of the Science Funds of Jiangxi Education Office (GJJ190597).

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Authors and Affiliations

  1. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, 330013, Nanchang, People’s Republic of China

    **n Mei, Hui Li & Shouzhi Pu

  2. Departemnt of Ecology and Environment, Yuzhang Normal University, 330013, Nanchang, People’s Republic of China

    Shouzhi Pu

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  1. **n Mei
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Contributions

All authors contributed to the design and synthesis of this study. All authors performed the experimental material preparation, data testing and analysis of the results. The first draft of the manuscript was written by **n Mei and all authors read and approved the final manuscript.

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Correspondence to Hui Li or Shouzhi Pu.

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Mei, X., Li, H. & Pu, S. A Handy Chemical Sensor Based on Benzaldehyde and Imidazo[1,2-a]pyridine Mixture for Naked-eye Colorimetric and Fluorescent Detection of F−. J Fluoresc 33, 2381–2390 (2023). https://doi.org/10.1007/s10895-023-03195-2

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