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The Novel Fluorescent Probe Toward Yttrium(III) and its Bioimaging

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Abstract

In this paper, the novel fluorescence probe XP based on Schiff-base was designed, synthesized and characterized, which could detect Y3+selectively and sensitively. The recognition mechanism of XP toward Y3+ was studied by Job's plot and HRMS. It was investigated that stoichiometric ratio of the probe XP conjugated with Y3+ was 1:2. And the detection limit was calculated as 0.30 μM. In addition, Y3+ was recognized by the test paper made from XP. And the probe XP could detect  Y3+ selectively in Caenorhabditis elegans and the main organs of mice. Thus, XP was considered to have some potential for application in bioimaging.

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Funding

This work was supported the Key Projects of Natural Science Research of Anhui Province Colleges and Universities (KJ2021A0667, KJ2020A05250 and KJ2021A0673), the Key Projects of Support Program for Outstanding Young Talents in Anhui Province Colleges and Universities (gxyqZD2022065), the Undergraduate Training Programs for Innovation and Entrepreneurship (202110371004 and S202110371019), and the Key Natural Science Research Projects of Fuyang Normal University (2021FSKJ06ZD). This work was also supported by Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE (M2023-2) and Horizontal Cooperation Project of Fuyang Municipal Government-Fuyang Normal University (SXHZ202002 and SXHZ202102).

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Authors and Affiliations

  1. Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational Institutions, Anhui Provincial Key Laboratory for Degradation and Monitoring of Pollution of the Environment, School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang, Anhui Province, 236037, People’s Republic of China

    Yuxin Qin, Qian Meng, Junxiong Yao, Mengyu Chen, Yajie Dong, Dashuo Chen, Shu** He, Cuibing Bai, Lin Zhang, Biao Wei, Hui Miao & Rui Qiao

  2. Research Center of Anti-Aging Chinese Herbal Medicine of Anhui Province, Fuyang Normal University, Fuyang, Anhui Province, 236037, People’s Republic of China

    Changqing Qu

Authors
  1. Yuxin Qin
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  2. Qian Meng
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  3. Junxiong Yao
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  4. Mengyu Chen
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  5. Yajie Dong
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  6. Dashuo Chen
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  7. Shu** He
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  9. Lin Zhang
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  12. Changqing Qu
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  13. Rui Qiao
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Contributions

Yuxin, Qin: experimental data processing, investigation and analysis, writing and editing. Qian Meng, Junxiong Yao, Mengyu Chen, Yajie Dong, Dashuo Chen and Shu** He: synthesis and characterization, spectral analysis, biological property testing. Cuibing Bai: supervision, fund acquisition, writing, review and editing. Lin Zhang, Biao Wei and Hui Miao: synthesis, spectral analysis and fund acquisition. Changqing Qu: analysis of biological test results. Rui Qiao: investigation, supervision, project management, fund acquisition, writing, review and editing.

Corresponding authors

Correspondence to Cuibing Bai, Changqing Qu or Rui Qiao.

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Ethical Approval

The animal studies were approved by the Experimental Animal Welfare and Ethics Committee and the Experimental Animal Management Committee of Fuyang Normal University, and were performed in compliance with the guidelines for the care and use of laboratory animals.

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Qin, Y., Meng, Q., Yao, J. et al. The Novel Fluorescent Probe Toward Yttrium(III) and its Bioimaging. J Fluoresc 33, 731–737 (2023). https://doi.org/10.1007/s10895-022-03106-x

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