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Novel NF-kappa B Inhibitor Alpha Gain-of-Function Variant in an Infant with Lymphocytosis and Recurrent Serratia Bacteremia

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Acknowledgements

We kindly acknowledge Dr. Amy Pallor from Ann & Robert H Lurie Children’s Hospital of Chicago Division of Dermatology for hel** with the collection and culture of the patient’s fibroblasts for functional studies and Luisa Kamm and Tatiana Kochetkov from Dr. Casanova’s lab for technical support. We also acknowledge Dr. Kai Lee Yap’s Molecular Lab, also at Lurie Children’s, for their work on the whole genome research study performed for this case.

Funding

The Laboratory of Human Genetics of Infectious Diseases was supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (P01AI061093), the French National Research Agency (ANR) under the “Investments for the Future” program (ANR-10-IAHU-01), the French Foundation for Medical Research (FRM; EQU201903007798), the Square Foundation, Grandir—Fonds de solidarité pour l’enfance, the Fondation du Souffle, the SCOR Corporate Foundation for Science, Institut National de la Santé et de la Recherche Médicale (INSERM), and the University of Paris Cité.

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Authors and Affiliations

  1. Department of Allergy and Immunology, Ann & Robert H Lurie Children’s Hospital of Chicago, 225 E. Chicago Avenue, Box 60, Chicago, IL, USA

    Lauren M. Gunderman

  2. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA

    Takaki Asano, Jean-Laurent Casanova & Bertrand Boisson

  3. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France

    Jean-Laurent Casanova & Bertrand Boisson

  4. Imagine Institute, University Paris Cité, Paris, France

    Jean-Laurent Casanova & Bertrand Boisson

  5. Department of Pediatrics, Necker Hospital for Sick Children, Paris, France

    Jean-Laurent Casanova

  6. Howard Hughes Medical Institute, New York, NY, USA

    Jean-Laurent Casanova

  7. Pediatrics Department, College of Medicine at Umm Al-Qura University, Mecca, Saudi Arabia

    Amer Khojah

Authors
  1. Lauren M. Gunderman
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  2. Takaki Asano
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  3. Jean-Laurent Casanova
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  4. Bertrand Boisson
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  5. Amer Khojah
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Correspondence to Lauren M. Gunderman.

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Gunderman, L.M., Asano, T., Casanova, JL. et al. Novel NF-kappa B Inhibitor Alpha Gain-of-Function Variant in an Infant with Lymphocytosis and Recurrent Serratia Bacteremia. J Clin Immunol 43, 1122–1126 (2023). https://doi.org/10.1007/s10875-023-01481-z

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  • DOI: https://doi.org/10.1007/s10875-023-01481-z

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