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Catheter ablation for monomorphic ventricular tachycardia in Brugada syndrome patients: detailed characteristics and long-term follow-up

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Abstract

Purpose

Brugada syndrome (BrS) is a risk of sudden cardiac death due to polymorphic ventricular tachycardia and ventricular fibrillation with unusual monomorphic ventricular tachycardia (MVT). Detailed characteristics of MVT and long-term outcome of catheter ablation are still unknown. This study is aimed to identify the detailed characteristics and long-term follow-up of catheter ablation in BrS patients.

Methods

We evaluated 188 patients who were diagnosed with BrS from March 1999 to March 2018. Of those, patients who developed MVT and underwent catheter ablation were included. We identified eight MVTs in seven BrS patients.

Results

Three of them already had implantable cardioverter-defibrillator, and MVTs were terminated by cardioversion or anti-tachycardia pacing. Four patients presented with MVT originating from the right ventricular outflow tract, one patient had MVT arising from the LV septum, one patient had MVT arising from the tricuspid annulus, and one patient had bundle branch reentry ventricular tachycardia. All MVTs were successfully treated by catheter ablation in the acute phase, and seven of eight (87.5%) were free from ventricular tachyarrhythmia during the long-term follow-up (median, 7.2 years).

Conclusions

All MVT cases were successfully treated by catheter ablation. We observed high ventricular arrhythmia free rate following catheter ablation during the long-term follow-up period. BrS patients who developed MVT should consider catheter ablation.

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Authors and Affiliations

  1. Department of Cardiology, Tokyo Metropolitan Hiroo Hospital, 2-34-10 Ebisu, Shibuya-ku, Tokyo, Japan

    Sayuri Tokioka, Seiji Fukamizu, Takeshi Kitamura, Satoshi Miyazawa, Iwanari Kawamura & Rintaro Hojo

  2. Department of Cardiology, Tokyo Metropolitan Health and Hospitals Corporation Ohkubo Hospital, Tokyo, Japan

    Harumizu Sakurada

  3. Department of Cardiology, Tokyo Medical Dental University, Tokyo, Japan

    Masayasu Hiraoka

Authors
  1. Sayuri Tokioka
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  2. Seiji Fukamizu
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  3. Takeshi Kitamura
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  4. Satoshi Miyazawa
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  5. Iwanari Kawamura
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  6. Rintaro Hojo
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  7. Harumizu Sakurada
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  8. Masayasu Hiraoka
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Corresponding author

Correspondence to Sayuri Tokioka.

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This retrospective observational study was approved by the Institutional Review Board of Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan.

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The authors declare that they have no conflict of interest.

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Tokioka, S., Fukamizu, S., Kitamura, T. et al. Catheter ablation for monomorphic ventricular tachycardia in Brugada syndrome patients: detailed characteristics and long-term follow-up. J Interv Card Electrophysiol 57, 97–103 (2020). https://doi.org/10.1007/s10840-019-00620-0

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  • DOI: https://doi.org/10.1007/s10840-019-00620-0

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